Target Binding Site Detail
Target General Information | Top | ||||
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Target ID | T15745 | Target Info | |||
Target Name | Bromodomain adjacent to zinc finger 2B (BAZ2B) | ||||
Synonyms | hWALp4; KIAA1476; Bromodomain adjacent to zinc finger domain protein 2B | ||||
Target Type | Literature-reported Target | ||||
Gene Name | BAZ2B | ||||
UniProt ID |
Ligand General Information | Top | ||||
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Ligand Name | 6-Hydroxypicolinic acid | Ligand Info | |||
Canonical SMILES | C1=CC(=O)NC(=C1)C(=O)O | ||||
InChI | 1S/C6H5NO3/c8-5-3-1-2-4(7-5)6(9)10/h1-3H,(H,7,8)(H,9,10) | ||||
InChIKey | VRCWSYYXUCKEED-UHFFFAOYSA-N | ||||
PubChem Compound ID | 242721 |
Drug Binding Sites of Target | Top | |||||
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PDB ID: 5PBA PanDDA analysis group deposition -- Crystal Structure of BAZ2B in complex with N09460a | ||||||
Method | X-ray diffraction | Resolution | 1.93 Å | Mutation | No | [1] |
PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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PDB ID: 5CQ3 Crystal structure of the bromodomain of bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) in complex with 6-Hydroxypicolinic acid (SGC - Diamond I04-1 fragment screening) | ||||||
Method | X-ray diffraction | Resolution | 1.93 Å | Mutation | No | [2] |
PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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References | Top | ||||
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REF 1 | A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun. 2017 Apr 24;8:15123. | ||||
REF 2 | Crystal structure of the second bromodomain of bromodomain adjancent to zinc finger domain protein 2B (BAZ2B) in complex with 6-Hydroxypicolinic acid (SGC - Diamond I04-1 fragment screening) |
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