Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15745 | Target Info | |||
| Target Name | Bromodomain adjacent to zinc finger 2B (BAZ2B) | ||||
| Synonyms | hWALp4; KIAA1476; Bromodomain adjacent to zinc finger domain protein 2B | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | BAZ2B | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 4-Hydroxyquinoline | Ligand Info | |||
| Canonical SMILES | C1=CC=C2C(=C1)C(=O)C=CN2 | ||||
| InChI | 1S/C9H7NO/c11-9-5-6-10-8-4-2-1-3-7(8)9/h1-6H,(H,10,11) | ||||
| InChIKey | PMZDQRJGMBOQBF-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 69141 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 5PBB PanDDA analysis group deposition -- Crystal Structure of BAZ2B in complex with N09496a | ||||||
| Method | X-ray diffraction | Resolution | 1.78 Å | Mutation | No | [1] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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| PDB ID: 4CUS Crystal structure of human BAZ2B in complex with fragment-4 N09496 | ||||||
| Method | X-ray diffraction | Resolution | 1.78 Å | Mutation | No | [2] |
| PDB Sequence |
SMSVKKPKRD
1865 DSKDLALCSM1875 ILTEMETHED1885 AWPFLLPVNL1895 KLVPGYKKVI1905 KKPMDFSTIR 1915 EKLSSGQYPN1925 LETFALDVRL1935 VFDNCETFNE1945 DDSDIGRAGH1955 NMRKYFEKKW 1965 TDTFK
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun. 2017 Apr 24;8:15123. | ||||
| REF 2 | Crystal Structure of Human Baz2B in Complex with Fragment-4 N09496 | ||||
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