Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99347 | Target Info | |||
| Target Name | Metabotropic glutamate receptor 5 (mGluR5) | ||||
| Synonyms |
MGLUR5; GPRC1E
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| Target Type | Clinical trial Target | ||||
| Gene Name | GRM5 | ||||
| Biochemical Class | GPCR glutamate | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 92 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
LY354740
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|
Discontinued in Phase 2 | Compound Info | ||
| Synonyms |
Eglumetad; Eglumegad; 176199-48-7; (1S,2S,5R,6S)-2-aminobicyclo[310]hexane-2,6-dicarboxylic acid; Eglumegad [INN]; UNII-ONU5A67T2S; LY-354740; LY 354740; ONU5A67T2S; CHEMBL8759; Eglumegad (INN); (1S,2S,5R,6S)-2-Aminobicyclo(310)hexane-2,6-dicarboxylic acid; (1R,4S,5S,6S)-4-aminobicyclo[310]hexane-4,6-dicarboxylic acid; (1S,2S,5R,6S)-2-Amino-bicyclo[310]hexane-2,6-dicarboxylic acid; [3H]Eglumegad; LY366563; Eglumetad [USAN:INN]; (+)-2-Aminobicyclo(310)hexane-2,6-dicarboxylic acid; 40F; PubChem18158; Eglumegad; Eglumegad [USAN]; Eglumegad hydrate; Eglumetad hydrate; LY 314582; LY 366563; LY314582; Eglumegad (USAN); LY-314582; LY-354740 monohydrate; LY-366563; Eglumetad (INN/USAN); (1R,4S,5S,6S)-4-aminobicyclo[310]hexane-4,6-dicarboxylic acid hydrate; (1S,2S,5R,6S)-2-Aminobicyclo(310)hexane-2,6-dicarboxylic acid monohydrate; 2-Aminobicyclo(310)hexane-2,6-dicarboxylic acid; 4-aminobicyclo[310]hexane-4,6-dicarboxylic acid; [3H]eglumegad
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
LY-367385
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Terminated | Compound Info | ||
| Synonyms |
Metabotropic mGluR1 agonists, Lilly; L-367385 analogs, Lilly
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
CPCCOEt
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL327783; 179067-99-3; AC1O3E8H; 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester; SCHEMBL12648369; MolPort-003-940-874; CPCCOEt, > AKOS024456339; LP00300; NCGC00024948-02; KB-49121; AS-16761; L000202; SR-01000597466; SR-01000597466-1; BRD-A05729358-001-01-2; ethyl (7E)-7-hydroxyimino-1,7a-dihydrocyclopropa[b]chromene-1a-carboxylate
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
LY-389795
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL88999; LY389795; LY-389795; GTPL3349; BDBM50089897; LY 389795; (4S,6S)-4-amino-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid; 4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid(LY389795)
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
LY-379268
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Investigative | Compound Info | ||
| Synonyms |
LY 379268; LY-379268; CHEMBL275079; LY379268; 191471-52-0; SCHEMBL2454646; GTPL1394; (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid; CTK8F0567; DTXSID90436637; ZINC3952369; BDBM50074749; FCH888149; AKOS006306876; API0003234; NCGC00159572-01; LS-98795; RT-013615; LY-379,268; B7061; J-012378; 4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid; (1S,2R,5R,6R)-2-amino-4-oxabicyclo[3.1.0]hexane-2,6-dicarboxylic acid; (1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
Ro64-5229
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Investigative | Compound Info | ||
| Synonyms |
Ro 64-5229
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
(2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate
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Investigative | Compound Info | ||
| Synonyms |
(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid; (2R,4R)-APDC; (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid; 169209-63-6; 2R,4R-APDC; CHEMBL40086; CHEBI:40139; EN300-88063; 2R, 4R-APDC monohydrate; 52A; 4-amino-2,4-pyrrolidinedicarboxylic acid; AC1NSJRT; AC1Q4UAD; SCHEMBL158843; 2R, 4R-APDC; (2R,3R)-APDC; GTPL1392; CTK0E5090; DTXSID10415500; MolPort-003-982-102; BDBM50052398; ZINC32628523; SBB067830; MFCD16875409; AKOS015916056; AKOS015854214; RTC-065564; FCH3884669; NCGC00025040-02; LY314593; AJ-85443; SC-48823; TC-065564; B6634
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
PMID17532216C2f
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Investigative | Compound Info | ||
| Synonyms |
GTPL6342; BDBM50214087
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
[(1R)-1-(5-Methyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-6-yl)ethyl] N-(3-fluorophenyl)carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1630080; BDBM50483145
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| Activity |
IC50 ~ 50118.72 nM
|
[4] | |||
| Compound Name |
(3-Amino-4,6-dimethylfuro[2,3-b]pyridin-2-yl)(4-fluorophenyl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1784106; Oprea1_729750; ZINC269575; BDBM50346079; STK769270; AKOS001745808; MCULE-2500335581; EU-0086714; (3-amino-4,6-dimethylfuro[2,3-b]pyridine-2-yl)(4-fluorophenyl)-methanone
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| Activity |
IC50 = 54000 nM
|
[5] | |||
| Compound Name |
L-Homocysteic acid
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Investigative | Compound Info | ||
| Synonyms |
(2S)-2-Amino-4-sulfobutanoic acid; L-2-Amino-4-sulfobutyric acid; L-HOMOCYSTEATE; Homocysteic acid; (S)-2-amino-4-sulfobutanoic acid; UNII-YW13F86W9W; CHEMBL230951; YW13F86W9W; (2~{S})-2-azanyl-4-sulfo-butanoic acid; L-2-Amino-4-sulfobutyrate; SCHEMBL157695; (S)-2-amino-4-sulfobutyric acid; ZINC2567965; (2S)-2-amino-4-sulfobutyric acid; BDBM50220147; MFCD00066018; PDSP1_001269; PDSP2_001253; C16511; H-2740; Q15410991; UNII-HYA2G5T79L component VBOQYPQEPHKASR-VKHMYHEASA-N
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| Activity |
Ki = 54000 nM
|
[6] | |||
| Compound Name |
Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1R,2R)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL230950; BDBM50220154; (2R,1''R,2''R)-2-(2''-sulfonocyclopropyl)glycine
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| Activity |
Ki = 55000 nM
|
[6] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-hexyl-cyclopropanecarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL319732; BDBM50072173; (1S,2S,3S)-2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-3-hexylcyclopropane-1-carboxylic acid
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| Activity |
IC50 = 56100 nM
|
[7] | |||
| Compound Name |
(1R,2S,4R,5R)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL46527; BDBM50064246; (1R,4R)-2beta-Aminobicyclo[2.1.1]hexane-2,5beta-dicarboxylic acid
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| Activity |
EC50 = 57000 nM
|
[8] | |||
| Compound Name |
4-(1H-Pyrazole-1-yl)-6-(3-fluoro-5-methoxyphenyl)pyrimidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3603911; BDBM50113464
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| Activity |
Ki ~ 63095.73 nM
|
[9] | |||
| Compound Name |
3-Fluoro-5-(6-(1H-pyrazole-1-yl)-4-pyrimidinyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3603912; BDBM50113465
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| Activity |
Ki ~ 63095.73 nM
|
[9] | |||
| Compound Name |
Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1S,2R)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL230852; BDBM50220150; (2R,1''S,2''R)-2-(2''-sulfonocyclopropyl)glycine
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| Activity |
Ki = 67000 nM
|
[6] | |||
| Compound Name |
Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaS,1S,2R)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL389555; BDBM50220149; (2S,1''S,2''R)-2-(2''-sulfonocyclopropyl)glycine
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| Activity |
Ki = 81000 nM
|
[6] | |||
| Compound Name |
(1S,2S,4S,5R)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL42148; BDBM50064247; (1S,4S)-2beta-Aminobicyclo[2.1.1]hexane-2,5beta-dicarboxylic acid
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| Activity |
EC50 = 91000 nM
|
[8] | |||
| Compound Name |
(S)-2-Amino-3-(4-butyl-3-hydroxy-isoxazol-5-yl)-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL315663; (R)-Bu-HIBO; (S)-4-Butylhomoibotenic acid; BDBM85348; BDBM50063485; 2-Amino-3-(4-butyl-3-hydroxy-isoxazol-5-yl)-propionic acid(S-Bu-HIBO)
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| Activity |
Ki = 97000 nM
|
[1] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(3,4-dichloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL59686; SCHEMBL8972863; BDBM50071163; (2R,4R)-4-amino-1-[(3,4-dichlorophenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
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| Activity |
IC50 = 99000 nM
|
[10] | |||
| Compound Name |
N-(4-Chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL396918; BDBM50202142
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| Activity |
EC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-propyl-cyclopropanecarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL99462; BDBM50072168; (1S,2S,3S)-2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-3-propylcyclopropane-1-carboxylic acid
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| Activity |
IC50 ~ 100000 nM
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[7] | |||
| Compound Name |
9-Dimethylamino-3-(2''-methoxy-5''-pyridyl)-3H-5-thia-1,3,6-triazafluoren-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL389870; SCHEMBL8236593; BDBM50177084; 9-Dimethylamino-3-(6-methoxy-pyridin-3-yl)-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
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| Activity |
IC50 ~ 100000 nM
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[12] | |||
| Compound Name |
5-(4-Chlorophenyl)-1-(cyclohexylmethyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL246610; BDBM50214072
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
8,8-Dimethyl-2-(4-methylanilino)-6,7-dihydroquinazolin-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2408407; BDBM50438282
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
13-(Dimethylamino)-5-(2-methylcyclohexyl)-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL224672; BDBM50177094; 9-Dimethylamino-3-(2-methyl-cyclohexyl)-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
5-(4-Chloro-3-fluorophenyl)-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL246839; BDBM50214082
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
5-(4-Bromophenyl)-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL248208; Oprea1_008673; Oprea1_765486; ZINC1104450; BDBM50214078; STK373462; AKOS005446835; MCULE-1360309496; ST010007; SR-01000359090; SR-01000359090-1; 5-(4-bromophenyl)-6-methyl-1-phenyl-5-hydropyrazolo[5,4-d]pyrimidin-4-one
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(4-Chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)-2-methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL245288; BDBM50202124
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| Activity |
EC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
6-Methyl-1-phenyl-5-(4-(trifluoromethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL248210; BDBM50214084
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
9-Dimethylamino-3-(2,4-dimethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL224356; BDBM50177065; 9-Dimethylamino-3-(2,4-dimethyl-phenyl)-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
5-(4-Chlorophenyl)-6-methyl-1-m-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL400307; BDBM50214088
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
5-(4-Chlorophenyl)-6-methyl-1-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL247216; BDBM50214069
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL8839; LY-389795; SCHEMBL2450641; CTK1A0220; DTXSID40436647; BDBM50074750; (1beta,5beta)-4-Amino-2-thiabicyclo[3.1.0]hexane-4beta,6beta-dicarboxylic acid; (1R,4S,5S,6S)-4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid; 2-Thiabicyclo[3.1.0]hexane-4,6-dicarboxylicacid, 4-amino-, (1R,4S,5S,6S)-
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| Activity |
EC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
9-Dimethylamino-3-(3-n-pentyl)-3H-5-thia-1,3,6-triazafluoren-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL223819; BDBM50177077; 9-Dimethylamino-3-(1-ethyl-propyl)-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
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| Activity |
IC50 ~ 100000 nM
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[12] | |||
| Compound Name |
9-Dimethylamino-3-(4-tert-butylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL225439; SCHEMBL8235438; BDBM50177091; 3-(4-tert-Butyl-phenyl)-9-dimethylamino-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
4-(6-Methyl-4-oxo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL398944; BDBM50214080
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| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-pentyl-cyclopropanecarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL329920; BDBM50072169; (1S,2S,3S)-2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-3-pentylcyclopropane-1-carboxylic acid
Click to Show/Hide
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-(3-Chlorophenyl)-5-(4-chlorophenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL399309; BDBM50214079
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
5-(4-Chlorophenyl)-6-methyl-1-(pyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL245991; BDBM50214081
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
9-Dimethylamino-3-(3-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL224084; BDBM50177055; 9-Dimethylamino-3-(3-ethyl-phenyl)-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
9-Dimethylamino-3-(4-ethylphenyl)-3H-5-thia-1,3-diazafluoren-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL389918; SCHEMBL6101268; BDBM50177090; 9-(dimethylamino)-3-(4-ethylphenyl)-[1]benzothiolo[3,2-d]pyrimidin-4-one
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
1,5-Bis(4-chlorophenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL399127; BDBM50214083
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(5-(4-Chlorophenyl)-6-methyl-4-oxo-4,5-dihydropyrazolo[3,4-d]pyrimidin-1-yl)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL248233; BDBM50214074
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(4-Chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)pyridazine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL247950; BDBM50202128
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
4-(Amino-carboxy-methyl)-2-hydroxy-3-methyl-benzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313124; SCHEMBL7393596; BDBM50089913; 4-[amino(carboxy)methyl]-2-hydroxy-3-methylbenzoic acid; 4-(Amino-carboxy-methyl)-2-hydroxy-3-methyl-benzoic acid(RS-4C3H2MPG)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-[Amino(carboxy)methyl]-3-methylbenzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315591; (+/-)-LY 367385; SCHEMBL1078997; BDBM50089896; 2-(4-Carboxy-2-methylphenyl)glycine; Racemic 2-(4-carboxy-2-methylphenyl)glycine; 4-(Amino-carboxy-methyl)-3-methyl-benzoic acid; alpha-amino-4-carboxy-2-methylbenzeneacetic acid; L000369; 4-(Amino-carboxy-methyl)-3-methyl-benzoic acid((+)-4C2MPG)
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
9-Cyclopropylamino-3-(4''-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL224088; SCHEMBL8244427; BDBM50177061; 9-Cyclopropylamino-3-(4-ethyl-phenyl)-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(4-Bromo-2-((4,5-dimethoxy-1,3-dioxoisoindolin-2-yl)methyl)phenyl)picolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL247349; BDBM50202129
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-(4-Chloroanilino)-7-propyl-7,8-dihydro-6H-quinazolin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2408578; BDBM50438285
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
5-(4-Ethylphenyl)-N,N-dimethyl-6-oxo-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-13-amine oxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390391; BDBM50177069; 9-(N,N,-dimethyl-N-oxyamino)-3-(4''-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one; 9-(dimethylnitroryl)-3-(4-ethylphenyl)pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4(3H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
6,6-Dimethyl-2-(4-methylanilino)-7,8-dihydroquinazolin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2408580; BDBM50438284
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-butyl-cyclopropanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL95868; BDBM50072177; (1S,2S,3S)-2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-3-butylcyclopropane-1-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
9-Dimethylamino-3-cyclopentylmethyl-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386935; BDBM50177098; 3-Cyclopentylmethyl-9-dimethylamino-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Methyl (1S,5R)-3-hydroxy-3-(2-imidazo[1,2-a]pyridin-2-ylethynyl)-8-azabicyclo[3.2.1]octane-8-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3087222; BDBM50443056
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
5-(4-Hydroxyphenyl)-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248209; BDBM50214090
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
5-(4-Chlorophenyl)-6-methyl-1-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399128; BDBM50214075
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[(3,5-Dimethylphenyl)amino]-6,7,8-trihydroquinazolin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1438160; MLS000082741; HMS2303D14; ZINC4295449; BDBM50438308; STK211321; STL049529; ZINC04295449; AKOS002272218; AKOS005702742; CCG-275121; MCULE-7965791969; SMR000046876; ST50162099; 2-[(3,5-dimethylphenyl)amino]-7,8-dihydroquinazolin-5(6H)-one; (2Z)-2-[(3,5-dimethylphenyl)imino]-2,6,7,8-tetrahydroquinazolin-5(1H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
9-Dimethylamino-3-cyclohexylmethyl-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL223868; SCHEMBL8235568; BDBM50177075; 3-Cyclohexylmethyl-9-dimethylamino-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(2-((1,3-Dioxoisoindolin-2-yl)methyl)-3-fluorophenyl)picolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246727; BDBM50202137
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
9-Dimethylamino-3-(o-hydroxyphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389897; BDBM50177067; 9-Dimethylamino-3-(2-hydroxy-phenyl)-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
9-(N,N-Dimethyl-N-oxyamino)-3-(N-hexamethyleneiminyl)-3H-5-thia-1,3,6-triaza-fluoren-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386408; BDBM50177051; 3-azepan-1-yl-9-(dimethylnitroryl)pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4(3H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
13-(Dimethylamino)-5-(4-ethylphenyl)-8-oxa-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL224377; BDBM50177088; 9-dimethylamino-3-(4''-ethylphenyl)-3H-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-ethyl-cyclopropanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL439775; BDBM50072172; (1S,2S,3S)-2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-3-ethylcyclopropane-1-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
5-(4-Ethylphenyl)-13-[2-methoxyethyl(methyl)amino]-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL225125; BDBM50177083; 9-(2''-methoxyethylmethylamino)-3-(4''-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
6-Methyl-1,5-di(pyrazin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399460; BDBM50214070
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
9-Dimethylamino-3-(2-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375439; BDBM50177056; 9-Dimethylamino-3-(2-ethyl-phenyl)-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
9-Dimethylamino-3-benzyl-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL388087; MLS000038237; Oprea1_532686; cid_657896; SCHEMBL8244926; HMS2439F05; ZINC4339374; BDBM50177064; STL323467; AKOS022110339; MCULE-3527362764; SMR000036367; SR-01000426473; SR-01000426473-1; 3-benzyl-9-(dimethylamino)pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one; 3-Benzyl-9-dimethylamino-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one; 9-(Dimethylamino)-3-benzylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
9-(Dimethylamino)-3-phenylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL224615; SMR000069218; ChemDiv2_004169; Cambridge id 5240467; Oprea1_187971; MLS000061150; SCHEMBL8238029; ZINC77553; HMS1380N11; HMS2401K09; BDBM50177079; CCG-20549; MCULE-4877268593; IDI1_002884; AB00076338-01; AH-262/36083015; 9-(dimethylamino)-3-phenylpyrido[1,2]thieno[3,4-d]pyrimidin-4-one; 9-dimethylamino-3-phenyl-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
5-(4-Chlorophenyl)-1-cycloheptyl-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400110; BDBM50214085
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(4-Chloro-2-((4,5-dimethoxy-1,3-dioxoisoindolin-2-yl)methyl)phenyl)picolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395645; BDBM50202132
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
9-Dimethylamino-3-cyclobutyl-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL385776; SCHEMBL8237698; BDBM50177060; 3-Cyclobutyl-9-dimethylamino-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-phenethyl-cyclopropanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319279; BDBM50072176
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
5-(4-Chlorophenyl)-13-(dimethylamino)-8-thia-5,10-diazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1951661; SCHEMBL8236458; BDBM50364722
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-methyl-cyclopropanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97574; BDBM50072171; (1S,2S,3S)-2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]-3-methylcyclopropane-1-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-isobutyl-cyclopropanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97200; BDBM50072170
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
9-Dimethylamino-3-(2,4-dichlorophenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL224898; BDBM50177081; 3-(2,4-Dichloro-phenyl)-9-dimethylamino-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
9-N-Azetidinyl-3-(4''-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL225126; BDBM50177058; 9-Azetidin-1-yl-3-(4-ethyl-phenyl)-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(4-Bromo-2-((4,5-dimethyl-1,3-dioxoisoindolin-2-yl)methyl)phenyl)picolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL247548; BDBM50202125
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
9-Dimethylamino-3-cyclopropyl-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL224135; SCHEMBL8236733; BDBM50177101; 3-Cyclopropyl-9-dimethylamino-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-(2-Chloroanilino)-7-methyl-7,8-dihydro-6H-quinazolin-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2408566; BDBM50438297
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
9-Dimethylamino-3-(p-trifluoromethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL224375; SCHEMBL8236636; BDBM50177057; 9-Dimethylamino-3-(4-trifluoromethyl-phenyl)-3H-pyrido[3'',2'':4,5]thieno[3,2-d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
5-(4-Ethylphenyl)-13-(2,2,2-trifluoroethylamino)-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL376372; BDBM50177071; 9-(2'',2'',2''-Trifluoroethylamino)-3-(4''-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
9-Dimethylamino-3-(1H-indazol-6-yl)-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL225438; BDBM50177082
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
9-Dimethylamino-3-(4-cyclohexylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374135; BDBM50177087
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-Amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid(HYDIA)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330097; BDBM50089895
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
2-((2-Chlorophenyl)amino)-7,8-dihydroquinazolin-5(6H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2408584; BDBM50438306
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
3-[Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL153572; SCHEMBL2266692; (R)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-1-carboxylic acid; BDBM50084139; 2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine; L000027
Click to Show/Hide
|
||||
| Activity |
EC50 = 103000 nM
|
[17] | |||
| Compound Name |
(2S,3S)-3-(Carboxymethyl)azetidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(2S,3S)-trans-3-(Carboxymethyl)-azetidine-2-acetic Acid; CHEMBL314690; CTK8F0661; ZINC4262470; BDBM50288204; ST50824727; J-011895; (2S,3S)-3-Carboxymethyl-azetidine-2-carboxylic acid
Click to Show/Hide
|
||||
| Activity |
EC50 = 105000 nM
|
[18] | |||
| Compound Name |
(2S)-2-Amino-4-(4-oxo-1,2,5-thiadiazol-3-yl)butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL131922; BDBM50118480
Click to Show/Hide
|
||||
| Activity |
EC50 = 190000 nM
|
[19] | |||
| Compound Name |
(S)-4-((1-Carboxyethyl)amino)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL58247; 4-[[(1S)-1-carboxyethyl]amino]benzoic acid; 4-{[(1S)-1-carboxyethyl]amino}benzoic acid; SCHEMBL350279; KS-00001CM5; BDBM50071162; ZINC52969665; 4-((S)-1-Carboxy-ethylamino)-benzoic acid; (2S)-2-[(4-Carboxyphenyl)amino]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 195000 nM
|
[10] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 54 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
L-Glutamic Acid
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Aciglut; Glu; Glusate; Glut; Glutacid; Glutamicol; Glutamidex; Glutaminol; Glutaton; Gulutamine; Acide glutamique; Acido glutamico; Acidum glutamicum; Acidum glutaminicum; Glutamic acid polymer; Glutaminic acid; E 620; A-Aminoglutaric acid; A-Glutamic acid; Acide glutamique [INN-French]; Acido glutamico [INN-Spanish]; Acidum glutamicum [INN-Latin]; D-Glutamiensuur; Glutamic Acid [USAN:INN]; Glutamic acid (VAN); Glutaminic acid (VAN); Gulutamine (USP); L-Glutamic acid hydrochloride; L-Glutaminic acid; L-Glutaminsaeure; L-glu; L-glutamate; Alpha-Aminoglutaric acid (VAN); Alpha-L-Glutamic acid polymer; Glutamic Acid (L-glutamic acid); Glutamic acid (H-3); H-Glu-OH; L-2-Aminoglutaric acid; L-Glutamic acid (9CI); L-Glutamic acid (JAN); L-Glutamic acid, homopolymer; L-a-Aminoglutaric acid; L-alpha-Aminoglutaric acid; Poly-L-glutamate; Sodium Glutamate (L-glutamic Acid); Glutamic acid, L-, peptides; L-Glutamic acid, homopolymer (9CI); Poly(alpha-L-glutamic acid); Glutamic acid, L-(7CI,8CI); L-(+)-glutamic acid; (S)-(+)-Glutamic acid; (S)-2-Aminopentanedioic acid; (S)-Glutamic acid; 1-Aminopropane-1,3-dicarboxylic acid
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| Activity |
EC50 = 631000 nM
|
[20] | |||
| Compound Name |
1-benzyl-APDC
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL60238; 171336-76-8; (2R,4R)-1-BENZYL-4-AMINO-PYRROLIDINE-2,4-DIcarboxylic acid; GTPL1436; SCHEMBL8061968; CTK0A8043; DTXSID60573467; ZINC39952128; BDBM50071161; DB-064818; AJ-101168; FT-0772028; 4-amino-1-(phenylmethyl)pyrrolidine-2,4-dicarboxylic acid; (2R,4R)-4-amino-1-benzylpyrrolidine-2,4-dicarboxylic acid; (2R,4R)-4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid; (2R)-1-Benzyl-4-aminopyrrolidine-2beta,4alpha-dicarboxylic acid; 4-Amino-1-benzyl-pyrrolidine-2,4-dicarboxylic acid(1-benzyl-APDC)
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||||
| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
LY307452
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Investigative | Compound Info | ||
| Synonyms |
LY-307452; LY-307,452; LY 307452
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| Activity |
Ki > 300000 nM
|
[1] | |||
| Compound Name |
(R,S)-4-phosphonophenylglycine
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Investigative | Compound Info | ||
| Synonyms |
(RS)-PPG; 120667-15-4; 2-amino-2-(4-phosphonophenyl)acetic acid; CHEMBL277475; AC1ND7MS; (RS)PPG; (RS) PPG; C8H10NO5P; (RS)-4-Phosphonophenylglycine; GTPL1406; SCHEMBL9150881; CTK8F0597; (R,S)-4-PPG; MolPort-003-983-668; BN0429; BDBM50004881; AKOS015911887; Amino-(4-phosphono-phenyl)-acetic acid; NCGC00025051-02; RT-015313; V2034; Amino-(4-phosphono-phenyl)-acetic acid(RS-PPG); SR-01000597406; 667P154; L000025; SR-01000597406-1; J-004376
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||||
| Activity |
Ki > 500000 nM
|
[1] | |||
| Compound Name |
AIDA
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Investigative | Compound Info | ||
| Synonyms |
UPF 523; UPF523; GNF-Pf-1401
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||||
| Activity |
Ki > 1000000 nM
|
[1] | |||
| Compound Name |
MPPG
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Investigative | Compound Info | ||
| Synonyms |
MPPG; 169209-65-8; 2-amino-2-(4-phosphonophenyl)propanoic acid; CHEMBL86508; AC1N11KO; GTPL1415; SCHEMBL12648709; CTK8F0596; DTXSID80398316; MolPort-003-983-629; MPPG, >=97% (NMR), solid; BDBM50089910; MFCD00672651; BN0344; AKOS024458668; API0007557; (RS)- -Methyl-4-phosphonophenylglycine; NCGC00024826-02; (RS)-; A-Methyl-4-phosphonophenylglycine; RT-013949; 2-Amino-2-(4-phosphono-phenyl)-propionic acid; L000410; SR-01000597457; J-010517; SR-01000597457-1; 2-Amino-2-(4-phosphono-phenyl)-propionic acid(RS-MPPG)
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||||
| Activity |
Ki > 1000000 nM
|
[1] | |||
| Compound Name |
L-AP4
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Investigative | Compound Info | ||
| Synonyms |
(2S)-2-Amino-4-phosphonobutanoic acid; 23052-81-5; (2S)-2-amino-4-phosphonobutanoic acid; L-(+)-2-Amino-4-phosphonobutyric acid; L-APB; (S)-2-amino-4-phosphonobutanoic acid; CHEMBL33567; L-AP-4; S-2-amino-4-phosphonobutyrate; [3H]AP4; L-2-amino-4-phosphonobutiric acid; L-1-amino-4-phosphonobutanoic acid; Tocris-0103; NCIStruc2_000128; NCIStruc1_000162; SCHEMBL1969235; GTPL1410; GTPL1412; AC1L456H; MolPort-002-514-399; NCI30079; ZINC2033983; BN0084; CCG-37553; NCGC00013365
Click to Show/Hide
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||||
| Activity |
Ki > 1000000 nM
|
[21] | |||
| Compound Name |
(2S)-2-(3''-Carboxymethylbicyclo[1.1.1]pentyl)glycine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL467234; BDBM50254389
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||||
| Activity |
Ki = 293000 nM
|
[21] | |||
| Compound Name |
(2R,4R)-4-Amino-1-methylpyrrolidine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL300330; SCHEMBL14278713; CTK1A0056; DTXSID10658238; BDBM50071164; ZINC29571185; (2R,4R)-4-Amino-1-methyl-pyrrolidine-2,4-dicarboxylic acid; 2,4-Pyrrolidinedicarboxylicacid, 4-amino-1-methyl-, (2R,4R)-
Click to Show/Hide
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||||
| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
(2R,4R)-4-Amino-1-biphenyl-2-ylmethyl-pyrrolidine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL293434; SCHEMBL8973026; BDBM50071150; (2R,4R)-4-amino-1-[(2-phenylphenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
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||||
| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(3-chloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL60008; SCHEMBL8973090; BDBM50071168; (2R,4R)-4-amino-1-[(3-chlorophenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
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||||
| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
4-(Amino-carboxy-methyl)-2-hydroxy-5-methyl-benzoic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL329905; SCHEMBL7396587; BDBM50290679; 2-(4-Carboxy-3-hydroxy-6-methylphenyl)glycine; 4-[amino(carboxy)methyl]-2-hydroxy-5-methylbenzoic acid
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||||
| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
(2R,4R)-4-Amino-1-naphthalen-2-ylmethyl-pyrrolidine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL61281; SCHEMBL8973223; BDBM50071155; (2R,4R)-4-amino-1-(naphthalen-2-ylmethyl)pyrrolidine-2,4-dicarboxylic acid
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||||
| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
(2S,4S)-2-Amino-4-(2,2-diphenylethyl)pentanedioic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL40123; SCHEMBL187449; BDBM50069111; ZINC13797034; 2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid; (2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid
Click to Show/Hide
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||||
| Activity |
Ki > 300000 nM
|
[1] | |||
| Compound Name |
(2R)-2-(3''-Carboxymethylbicyclo[1.1.1]pentyl)glycine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL448885; BDBM50254390
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||||
| Activity |
Ki > 300000 nM
|
[21] | |||
| Compound Name |
3-[(R)-Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL97083; (R)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-1-carboxylic acid; SCHEMBL2266688; CTK7I3071; (R)-(?)-CBPG; BDBM50052255; ZINC12506682; AKOS026740796; CS-0078705; EN300-88067; 1-[(R)-amino(carboxy)methyl]bicyclo[1.1.1]pentane-3-carboxylic acid; 3-((R)-Amino-carboxy-methyl)-bicyclo[1.1.1]pentane-1-carboxylic acid
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||||
| Activity |
IC50 > 300000 nM
|
[22] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(naphthalen-1-ylmethyl)pyrrolidine-2,4-dicarboxylic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL302411; SCHEMBL8973459; BDBM50071159; (2R,4R)-4-Amino-1-naphthalen-1-ylmethyl-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
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||||
| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
(2R,4R)-4-Amino-1-phenethyl-pyrrolidine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL292553; SCHEMBL8972917; BDBM50071152; (2R,4R)-4-amino-1-(2-phenylethyl)pyrrolidine-2,4-dicarboxylic acid
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||||
| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(2,4-dichloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL59920; BDBM50071153; (2R,4R)-4-amino-1-[(2,4-dichlorophenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
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||||
| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(3-phenyl-propyl)-pyrrolidine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL406215; SCHEMBL8973322; BDBM50071154; (2R,4R)-4-amino-1-(3-phenylpropyl)pyrrolidine-2,4-dicarboxylic acid
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||||
| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(4-chloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL61964; SCHEMBL8973457; BDBM50071157; (2R,4R)-4-amino-1-[(4-chlorophenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
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||||
| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
(2R,4R)-4-Amino-1-cyclohexylmethyl-pyrrolidine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL418650; SCHEMBL8973301; BDBM50071160; (2R,4R)-4-amino-1-(cyclohexylmethyl)pyrrolidine-2,4-dicarboxylic acid
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||||
| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1R,2S)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL389556; BDBM50220153; (2R,1''R,2''S)-2-(2''-sulfonocyclopropyl)glycine
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| Activity |
Ki > 300000 nM
|
[6] | |||
| Compound Name |
(2R,4R)-4-Amino-1-benzhydrylpyrrolidine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1169414; SCHEMBL8973161; BDBM50366533
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| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaS,1R,2R)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL389557; BDBM50220145; (2S,1''R,2''R)-2-(2''-sulfonocyclopropyl)glycine
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| Activity |
Ki > 300000 nM
|
[6] | |||
| Compound Name |
(1S,3S)-1-Aminocyclopentane-1,3-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
cis-ACPD; CHEMBL29726; Cis-1-aminocyclopentane-1,3-dicarboxylic acid; (+/-)-trans-ACPD; 1-amino-cis-cyclopentane-1,3-dicarboxylic acid; 1S, 3R-ACPD; (1S,3S)-ACPD; Tocris-0186; Tocris-0187; Tocris-0284; 1,3-Cyclopentanedicarboxylicacid, 1-amino-, (1S,3S)-; 1R,3R-ACPD; 1R,3S-ACPD; 1S,3S-ACPD; (+/-)-1-AMINOCYCLOPENTANE-cis-1,3-DICARBOXYLIC ACID; SCHEMBL481144; CTK0H2865; YFYNOWXBIBKGHB-FFWSUHOLSA-; ZINC1641373; BDBM50004863; MFCD00153759; AKOS006273106; NCGC00024487-01; NCGC00024488-01; NCGC00024488-02; B6219; 1-Aminocyclopentane-cis-1,3-dicarboxylic acid; M01251; A824378; SR-01000597676; 1-Amino-cyclopentane-1,3-dicarboxylic acid (APCD); SR-01000597676-1; (1S,3S)-1-Amino-cyclopentane-1,3-dicarboxylic acid; (1S,3S)-1-azanylcyclopentane-1,3-dicarboxylic acid; Q27458657; 1-Amino-cyclopentane-1,3-dicarboxylic acid(cis-(1S,3S)-ACPD)
Click to Show/Hide
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| Activity |
EC50 > 300000 nM
|
[8] | |||
| Compound Name |
(2S)-(3''-Phosphonomethylbicyclo[1.1.1]pentyl)glycine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL445241; BDBM50254391
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| Activity |
Ki > 300000 nM
|
[21] | |||
| Compound Name |
(2R,4R)-4-Amino-1-biphenyl-4-ylmethyl-pyrrolidine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL304034; SCHEMBL8973013; BDBM50071158; (2R,4R)-4-amino-1-[(4-phenylphenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
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||||
| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
(2R,4R)-4-Amino-1-ethylpyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL59830; CTK1A0057; DTXSID80658240; BDBM50071156; ZINC26157741; (2R,4R)-4-Amino-1-ethyl-pyrrolidine-2,4-dicarboxylic acid; 2,4-Pyrrolidinedicarboxylicacid, 4-amino-1-ethyl-, (2R,4R)-
Click to Show/Hide
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| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
(2S)-3-(3''-Carboxybicyclo[1.1.1]pentyl)alanine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL444718; BDBM50254337
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||||
| Activity |
Ki > 300000 nM
|
[21] | |||
| Compound Name |
Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1S,2S)-
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL230949; BDBM50220151; (2R,1''S,2''S)-2-(2''-sulfonocyclopropyl)glycine
Click to Show/Hide
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| Activity |
Ki > 300000 nM
|
[6] | |||
| Compound Name |
Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaS,1S,2S)-
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL389558; BDBM50220146; (2S,1''S,2''S)-2-(2''-sulfonocyclopropyl)glycine
Click to Show/Hide
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||||
| Activity |
Ki > 300000 nM
|
[6] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(3,3-diphenyl-propyl)-pyrrolidine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL60302; BDBM50071166; (2R,4R)-4-amino-1-(3,3-diphenylpropyl)pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
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||||
| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(2,2-diphenyl-ethyl)-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL304919; SCHEMBL8972526; BDBM50071151; (2R,4R)-4-amino-1-(2,2-diphenylethyl)pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
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| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(2,6-dichloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL60164; BDBM50071167; (2R,4R)-4-amino-1-[(2,6-dichlorophenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
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||||
| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
(2R,4R)-4-Amino-1-(2-chloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL418462; SCHEMBL8973329; BDBM50071165; (2R,4R)-4-amino-1-[(2-chlorophenyl)methyl]pyrrolidine-2,4-dicarboxylic acid
Click to Show/Hide
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||||
| Activity |
IC50 > 300000 nM
|
[10] | |||
| Compound Name |
(2R)-3-(3''-Carboxybicyclo[1.1.1]pentyl)alanine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450025; BDBM50254338
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|
||||
| Activity |
Ki = 336000 nM
|
[21] | |||
| Compound Name |
N-(4-Chloro-2-((3,5-dichloro-N-ethylbenzamido)methyl)phenyl)picolinamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL245854; SCHEMBL4068735; BDBM50202141; N-[4-chloro-2-[[(3,5-dichlorobenzoyl)-ethylamino]methyl]phenyl]pyridine-2-carboxamide
Click to Show/Hide
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||||
| Activity |
EC50 = 470000 nM
|
[11] | |||
| Compound Name |
(S)-Hibo
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL88184; NSC_194385; 2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid; BDBM85355; CTK5D3927; BDBM50089901; PDSP1_001437; PDSP2_001421; 5-Isoxazolepropanoicacid, a-amino-2,3-dihydro-3-oxo-; 2-Amino-3-(3-hydroxy-isoxazol-5-yl)-propionic acid(S-HIBO)
Click to Show/Hide
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||||
| Activity |
Ki = 490000 nM
|
[1] | |||
| Compound Name |
(2S)-2-Amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-4-yl)-2-methylpropanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL313713; BDBM50089891; 2-Amino-3-(3-hydroxy-5-oxo-[1,2,4]oxadiazol-4-yl)-2-methyl-propionic acid(S-MetQUIS)
Click to Show/Hide
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| Activity |
Ki = 1000000 nM
|
[1] | |||
| Compound Name |
(RS)-Apica
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
1-amino-5-phosphono-2,3-dihydroindene-1-carboxylic acid; CHEMBL277961; (RS)-1-Amino-5-phosphonoindan-1-carboxylic acid; (S)-MPPG (cyclic); 1-Amino-5-phosphono-indan-1-carboxylic acid; 1H-Indene-1-carboxylicacid; SCHEMBL2799885; CTK8F2086; BDBM50089893; AKOS024456371; NCGC00024982-02; SR-01000597477; J-010657; J-013076; SR-01000597477-1; 1-Amino-5-phosphono-indan-1-carboxylic acid(RS-APICA)
Click to Show/Hide
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||||
| Activity |
Ki > 1000000 nM
|
[1] | |||
| Compound Name |
2-Amino-4-(4-hydroxy-[1,2,5]thiadiazol-3-yl)-butyric acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL334842; SCHEMBL3261303; (2R)-2-amino-4-(4-oxo-1,2,5-thiadiazol-3-yl)butanoic Acid; BDBM50118479
Click to Show/Hide
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||||
| Activity |
EC50 > 1000000 nM
|
[19] | |||
| Compound Name |
(2R)-(3'-Phosphonomethylbicyclo[1.1.1]pentyl)glycine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL467235; BDBM50254392; (2R)-(3''-Phosphonomethylbicyclo[1.1.1]pentyl)glycine
Click to Show/Hide
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||||
| Activity |
Ki > 1000000 nM
|
[21] | |||
| Compound Name |
(S)-4-(Amino(carboxy)methyl)cubane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2021372; SCHEMBL7711939; BDBM50400856; CS-0091145
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| Activity |
Ki > 1000000 nM
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[1] | |||
| Compound Name |
(S)-2-Amino-5-phosphonopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
L-AP5; 5-phosphono-L-norvaline; CHEMBL71898; 2-Amino-5-phosphono-pentanoic acid; L(+)-2-Amino-5-phosphonopentanoic acid; Tocris-0107; SCHEMBL1662220; CTK7I3523; ZINC1854168; BDBM50017229; (s)-2-amino-5-phosphonovaleric acid; (S)-2-amino-5-phosphonopentanoicacid; AKOS024456367; (2S)-2-azaniumyl-5-phosphonopentanoate; (S)-2-Amino-5-phosphono-pentanoic acid; NCGC00024472-01; L-(+)-2-Amino-5-phosphonopentanoic acid; (2~{S})-2-azanyl-5-phosphono-pentanoic acid; SR-01000597696; SR-01000597696-1; UNII-39PJ29YY8Z component VOROEQBFPPIACJ-BYPYZUCNSA-N
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| Activity |
Ki > 1000000 nM
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[1] | |||
| Compound Name |
(2R,4R)-1,4-Diamino-pyrrolidine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL297150; BDBM50078596; 4-Amino-2,4-dicarboxy-pyrrolidin-1-yl-ammonium(1-Amino-APDC)
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| Activity |
Ki > 1000000 nM
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[1] | |||
| Compound Name |
(R)-1-Amino-indan-1,5-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL358882; Tocris-0904; Lopac-A-254; SCHEMBL13745377; ZINC20684; BDBM50084136; 1alpha-Aminoindan-1,5-dicarboxylic acid; NCGC00015024-01; NCGC00015024-02; NCGC00024861-01
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| Activity |
IC50 > 1000000 nM
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[17] | |||
| Compound Name |
(1R,2S,4R,5S)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL43857; BDBM50064245; (1R,4R)-2beta-Aminobicyclo[2.1.1]hexane-2,5alpha-dicarboxylic acid
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| Activity |
EC50 > 1000000 nM
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[8] | |||
| Compound Name |
(1S,2S)-1-Amino-2-(carboxymethyl)cyclopropane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CTK0H1302; CHEMBL3347671; DTXSID20472068; ZINC32629480; AKOS026740805; Cyclopropaneaceticacid, 2-amino-2-carboxy-, (1S,2S)-
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| Activity |
EC50 > 1000000 nM
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[19] | |||
| Compound Name |
2-Amino-bicyclo[3.2.0]heptane-2,7-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL313394; SCHEMBL13319983; BDBM50089898; (2S,7S)-2-Amino-bicyclo[3.2.0]heptane-2,7-dicarboxylic acid
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| Activity |
Ki > 1000000 nM
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[1] | |||
| Compound Name |
2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL315268; (S)-Homo-AMPA; NCGC00024946-01; Tocris-1026; SCHEMBL12506417; BDBM50060719; (s)-2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid; (S)-2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid; 2-Amino-4-(3-hydroxy-5-methyl-isoxazol-4-yl)-butyric acid(S-homo-AMPA)
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| Activity |
Ki > 1000000 nM
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[1] | |||
| Compound Name |
L-2-Aminoadipic acid
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Investigative | Compound Info | ||
| Synonyms |
(S)-2-aminohexanedioic acid; L-alpha-Aminoadipic acid; (2S)-2-aminohexanedioic acid; L-alpha-Aminoadipate; L-2-Aminoadipate; L-Homoglutamic acid; l-2-amino adipic acid; homoglutamic acid; (S)-2-Aminoadipic acid; UNII-88ZH74L7SR; hexanedioic acid, 2-amino-, (2S)-; h-2-aad-oh; l-a-aminoadipic acid; h-l-2-aad-oh; MFCD00002636; L-2-Aminohexanedioate; CHEMBL88804; 88ZH74L7SR; L-2-Aminoadipic acid, 98%; A-aminoadipic acid; Adipic acid, 2-amino-; alpha-Aminoadipate, L-; 2-Aminoadipic acid, L-; L-alpha-Aminoadipatic acid; Hexanedioic acid, 2-amino-, (S)-; l-a-aminohexanoic acid; (S)-Aminoadipic Acid; L-2-amino-adipic acid; aminoadipic acid, l-2-; l-alpha-amino-adipic acid; L -alpha-aminoadipic acid; (2S)-2-aminoadipic acid; l-alpha-aminohexanedioic acid; Lopac0_000091; SCHEMBL97323; KSC493I2B; (S)-2-amino-hexanedioic acid; (2S)-2-Amino-hexanedioic Acid; CTK3J3420; DTXSID801017096; HMS3260C04; KS-00000YV4; ZINC1532798; Tox21_500091; ANW-43725; BDBM50052553; AKOS015920301; CCG-204186; LP00091; SDCCGSBI-0050079.P002; L-2-Aminoadipic acid, >=98% (TLC); NCGC00093593-01; NCGC00093593-02; NCGC00093593-03; NCGC00093593-04; NCGC00260776-01; AS-13597; BR-25294; SC-10038; AB0013911; EU-0100091; A 7275; C00956; M-3010; 118A907; SR-01000075684; J-002657; SR-01000075684-1; Q27104392; Aad; (S)-2-Aminohexanedioic acid; L-Homoglutamic acid; 9EF7020B-8995-4D0E-BE44-34D8F18766DF; UNII-1K7B1OED4N component OYIFNHCXNCRBQI-BYPYZUCNSA-N
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| Activity |
Ki > 1000000 nM
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[1] | |||
| Compound Name |
alpha-Methyl-4-carboxyphenylglycine
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Investigative | Compound Info | ||
| Synonyms |
(RS)-MCPG; alpha-Mcpg; 4-(1-amino-1-carboxyethyl)benzoic acid; (+/-)-alpha-Methyl-4-carboxyphenylglycine; (R,S)-MCPG; Benzeneacetic acid, alpha-amino-4-carboxy-alpha-methyl-; CHEMBL299683; (+/-)-alpha-Methyl-(4-carboxyphenyl)glycine; (rs)-alpha-methyl-4-carboxyphenylglycine; Benzeneacetic acid, a-amino-4-carboxy-a-methyl-; (+/-)-MCPG; alpha-Amino-4-carboxy-alpha-methylbenzeneacetic acid; ACMC-20cchr; 4-(1-AMINO-1-CARBOXY-ETHYL)-BENZOIC ACID; Lopac0_000747; SCHEMBL715285; (+-)-MCPG; (+/-)MCPG; CTK4C5052; KS-00001CLO; DTXSID80861398; HMS3262E16; BCP18268; Benzeneacetic acid, alpha-amino-4-carboxy-alpha-methyl-, (+-)-; Tox21_500747; BDBM50030627; MFCD00210205; (RS)-?-Methyl-4-carboxyphenylglycine; AKOS005066801; CCG-204832; CS-5708; LP00747; SDCCGSBI-0050725.P002; (y)-alpha-Methyl-4-carboxyphenylglycine; (?)-alpha-Methyl-4-carboxyphenylglycine; alpha-Methyl-2-(4-carboxyphenyl)glycine; NCGC00015676-03; NCGC00015676-04; NCGC00015676-05; NCGC00015676-06; NCGC00015676-09; NCGC00024542-02; NCGC00024542-03; NCGC00024542-04; NCGC00261432-01; BS-15439; (r,s)-alpha-methyl-4-carboxyphenylglycine; HY-100371; EU-0100747; ST50825577; Benzeneacetic acid,a-amino-4-carboxy-a-methyl-; M 4796; L000020; SR-01000075733; J-008240; SR-01000075733-1; 4-(1-Amino-1-carboxy-ethyl)-benzoic acid(S-M4CPG); Q27268302
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| Activity |
Ki > 2000000 nM
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[1] | |||
| Compound Name |
Amino-(2-chloro-3,5-dihydroxy-phenyl)-acetic acid(S-CHPG)
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL316451; BDBM50089900
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| Activity |
Ki > 10000000 nM
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[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Ligands for glutamate receptors: design and therapeutic prospects. J Med Chem. 2000 Jul 13;43(14):2609-45. | ||||
| REF 2 | (+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg Med Chem Lett. 1997 Nov 4;7(21):2777-80. | ||||
| REF 3 | Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4303-7. | ||||
| REF 4 | The identification of novel orally active mGluR5 antagonist GSK2210875. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7521-4. | ||||
| REF 5 | Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3209-13. | ||||
| REF 6 | Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisom... J Med Chem. 2007 Sep 20;50(19):4630-41. | ||||
| REF 7 | 2,3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2849-54. | ||||
| REF 8 | Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist. J Med Chem. 1998 May 7;41(10):1641-50. | ||||
| REF 9 | Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile). J Med Chem. 2015 Aug 27;58(16):6653-64. | ||||
| REF 10 | Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid. Bioorg Med Chem Lett. 1998 Aug 4;8(15):1985-90. | ||||
| REF 11 | Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1386-91. | ||||
| REF 12 | Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists. J Med Chem. 2005 Nov 17;48(23):7374-88. | ||||
| REF 13 | Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4493-500. | ||||
| REF 14 | Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. J Med Chem. 1999 Mar 25;42(6):1027-40. | ||||
| REF 15 | Scaffold hopping approach towards various AFQ-056 analogs as potent metabotropic glutamate receptor 5 negative allosteric modulators. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6370-6. | ||||
| REF 16 | Fused tricyclic mGluR1 antagonists for the treatment of neuropathic pain. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1575-8. | ||||
| REF 17 | Modeling of amino-terminal domains of group I metabotropic glutamate receptors: structural motifs affecting ligand selectivity. J Med Chem. 1999 Dec 30;42(26):5390-401. | ||||
| REF 18 | Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA). Bioorg Med Chem Lett. 1996 Nov 5;6(21):2559-64. | ||||
| REF 19 | A highly selective agonist for the metabotropic glutamate receptor mGluR2. Medchemcomm. 2011;2:1120-4. | ||||
| REF 20 | Substituted 2-aminothiopen-derivatives: a potential new class of GluR6-antagonists. Eur J Med Chem. 2010 Jan;45(1):69-77. | ||||
| REF 21 | Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based omega-acidic amino acids as glutamate receptors ligands. Bioorg Med Chem. 2009 Jan 1;17(1):242-50. | ||||
| REF 22 | (S)-(+)-2-(3'-carboxybicyclo[1.1.1]pentyl)-glycine, a structurally new group I metabotropic glutamate receptor antagonist. J Med Chem. 1996 Jul 19;39(15):2874-6. | ||||
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