Drug Information
Drug General Information | Top | |||
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Drug ID |
D07GRG
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Former ID |
DNC007065
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Drug Name |
LY-379268
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Synonyms |
LY 379268; LY-379268; CHEMBL275079; LY379268; 191471-52-0; SCHEMBL2454646; GTPL1394; (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid; CTK8F0567; DTXSID90436637; ZINC3952369; BDBM50074749; FCH888149; AKOS006306876; API0003234; NCGC00159572-01; LS-98795; RT-013615; LY-379,268; B7061; J-012378; 4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid; (1S,2R,5R,6R)-2-amino-4-oxabicyclo[3.1.0]hexane-2,6-dicarboxylic acid; (1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C7H9NO5
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Canonical SMILES |
C1C(C2C(C2O1)C(=O)O)(C(=O)O)N
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InChI |
1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1
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InChIKey |
YASVRZWVUGJELU-MDASVERJSA-N
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CAS Number |
CAS 191471-52-0
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PubChem Compound ID | ||||
PubChem Substance ID |
Target and Pathway | Top | |||
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Target(s) | Metabotropic glutamate receptor 2 (mGluR2) | Target Info | Inhibitor | [2] |
Metabotropic glutamate receptor 3 (mGluR3) | Target Info | Inhibitor | [2] | |
KEGG Pathway | Neuroactive ligand-receptor interaction | |||
Glutamatergic synapse | ||||
Cocaine addiction | ||||
Panther Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | ||||
Ionotropic glutamate receptor pathway | ||||
Metabotropic glutamate receptor group II pathway | ||||
Reactome | G alpha (i) signalling events | |||
Class C/3 (Metabotropic glutamate/pheromone receptors) | ||||
WikiPathways | GPCRs, Class C Metabotropic glutamate, pheromone | |||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1394). | |||
REF 2 | Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identif... J Med Chem. 2007 Jan 25;50(2):233-40. |
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