TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T99347	Metabotropic glutamate receptor 5	D0U5CS	LY354740	Discontinued in Phase 2	213056	C8H11NO4	185.18	C1C[C@]([C@H]2[C@@H]1[C@@H]2C(=O)O)(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	D04JQR	LY-367385	Terminated	5311261	C10H11NO4	209.2	CC1=C(C=CC(=C1)C(=O)O)[C@@H](C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B10PDL	N-(4-Chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)benzamide	Investigative	44441377	C22H15ClN2O3	390.8	C1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)Cl)CN3C(=O)C4=CC=CC=C4C3=O	EC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B1KEW7	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-propyl-cyclopropanecarboxylic acid	Investigative	44329024	C23H25NO5	395.4	CCC[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B1MV6N	[(1R)-1-(5-Methyl-[1,3]thiazolo[2,3-c][1,2,4]triazol-6-yl)ethyl] N-(3-fluorophenyl)carbamate	Investigative	53316688	C14H13FN4O2S	320.34	CC1=C(SC2=NN=CN12)[C@@H](C)OC(=O)NC3=CC(=CC=C3)F	IC50 ~ 50118.72 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B1X7KZ	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-hexyl-cyclopropanecarboxylic acid	Investigative	44329031	C26H31NO5	437.5	CCCCCC[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 = 56100 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B2AT3K	9-Dimethylamino-3-(2''-methoxy-5''-pyridyl)-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11717319	C17H15N5O2S	353.4	CN(C)C1=C2C3=C(C(=O)N(C=N3)C4=CN=C(C=C4)OC)SC2=NC=C1	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B2C6GP	5-(4-Chlorophenyl)-1-(cyclohexylmethyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	44442427	C19H21ClN4O	356.8	CC1=NC2=C(C=NN2CC3CCCCC3)C(=O)N1C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B2EA9N	8,8-Dimethyl-2-(4-methylanilino)-6,7-dihydroquinazolin-5-one	Investigative	73356665	C17H19N3O	281.35	CC1=CC=C(C=C1)NC2=NC=C3C(=O)CCC(C3=N2)(C)C	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B2QZ3K	13-(Dimethylamino)-5-(2-methylcyclohexyl)-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one	Investigative	11515679	C18H22N4OS	342.5	CC1CCCCC1N2C=NC3=C(C2=O)SC4=NC=CC(=C34)N(C)C	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B2T0HS	(3-Amino-4,6-dimethylfuro[2,3-b]pyridin-2-yl)(4-fluorophenyl)methanone	Investigative	778172	C16H13FN2O2	284.28	CC1=CC(=NC2=C1C(=C(O2)C(=O)C3=CC=C(C=C3)F)N)C	IC50 = 54000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B2Z9YA	5-(4-Chloro-3-fluorophenyl)-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	44442422	C18H12ClFN4O	354.8	CC1=NC2=C(C=NN2C3=CC=CC=C3)C(=O)N1C4=CC(=C(C=C4)Cl)F	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B3EYN4	5-(4-Bromophenyl)-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	1284324	C18H13BrN4O	381.2	CC1=NC2=C(C=NN2C3=CC=CC=C3)C(=O)N1C4=CC=C(C=C4)Br	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B3X2TW	N-(4-Chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)-2-methoxybenzamide	Investigative	44441381	C23H17ClN2O4	420.8	COC1=CC=CC=C1C(=O)NC2=C(C=C(C=C2)Cl)CN3C(=O)C4=CC=CC=C4C3=O	EC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B4JKT7	6-Methyl-1-phenyl-5-(4-(trifluoromethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	44442420	C19H13F3N4O2	386.3	CC1=NC2=C(C=NN2C3=CC=CC=C3)C(=O)N1C4=CC=C(C=C4)OC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B4NJW1	9-Dimethylamino-3-(2,4-dimethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11688880	C19H18N4OS	350.4	CC1=CC(=C(C=C1)N2C=NC3=C(C2=O)SC4=NC=CC(=C34)N(C)C)C	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B4U7DN	5-(4-Chlorophenyl)-6-methyl-1-m-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	44442429	C19H15ClN4O	350.8	CC1=CC(=CC=C1)N2C3=C(C=N2)C(=O)N(C(=N3)C)C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B62AOF	5-(4-Chlorophenyl)-6-methyl-1-(pyrimidin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	44442435	C16H11ClN6O	338.75	CC1=NC2=C(C=NN2C3=CN=CN=C3)C(=O)N1C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B63JAR	4-(1H-Pyrazole-1-yl)-6-(3-fluoro-5-methoxyphenyl)pyrimidine	Investigative	122185329	C14H11FN4O	270.26	COC1=CC(=CC(=C1)C2=CC(=NC=N2)N3C=CC=N3)F	Ki ~ 63095.73 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B6BH5N	4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxylic acid	Investigative	10198133	C7H9NO4S	203.22	C1[C@]([C@@H]2[C@H]([C@@H]2S1)C(=O)O)(C(=O)O)N	EC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B6DV5R	9-Dimethylamino-3-(3-n-pentyl)-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11594849	C16H20N4OS	316.4	CCC(CC)N1C=NC2=C(C1=O)SC3=NC=CC(=C23)N(C)C	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B6PCX1	9-Dimethylamino-3-(4-tert-butylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	44421618	C21H22N4OS	378.5	CC(C)(C)C1=CC=C(C=C1)N2C=NC3=C(C2=O)SC4=NC=CC(=C34)N(C)C	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B7GQ1B	4-(6-Methyl-4-oxo-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)benzenesulfonamide	Investigative	44442421	C18H15N5O3S	381.4	CC1=NC2=C(C=NN2C3=CC=CC=C3)C(=O)N1C4=CC=C(C=C4)S(=O)(=O)N	IC50 = 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B7GRY1	(2S,3S)-3-(Carboxymethyl)azetidine-2-carboxylic acid	Investigative	2733519	C6H9NO4	159.14	C1[C@@H]([C@H](N1)C(=O)O)CC(=O)O	EC50 = 105000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B7LMV5	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-pentyl-cyclopropanecarboxylic acid	Investigative	44329032	C25H29NO5	423.5	CCCCC[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B85VAY	1-(3-Chlorophenyl)-5-(4-chlorophenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	44442430	C18H12Cl2N4O	371.2	CC1=NC2=C(C=NN2C3=CC(=CC=C3)Cl)C(=O)N1C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B8B3PA	5-(4-Chlorophenyl)-6-methyl-1-(pyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	44442433	C17H12ClN5O	337.8	CC1=NC2=C(C=NN2C3=CC=CC=N3)C(=O)N1C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B8LCX3	9-Dimethylamino-3-(3-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11717278	C19H18N4OS	350.4	CCC1=CC(=CC=C1)N2C=NC3=C(C2=O)SC4=NC=CC(=C34)N(C)C	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B8PEG2	Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1S,2R)-	Investigative	17758444	C5H9NO5S	195.2	C1[C@H]([C@@H]1S(=O)(=O)O)[C@H](C(=O)O)N	Ki = 67000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B95FZW	9-Dimethylamino-3-(4-ethylphenyl)-3H-5-thia-1,3-diazafluoren-4-one	Investigative	11703031	C20H19N3OS	349.5	CCC1=CC=C(C=C1)N2C=NC3=C(C2=O)SC4=CC=CC(=C43)N(C)C	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B9AWT1	1,5-Bis(4-chlorophenyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	44442432	C18H12Cl2N4O	371.2	CC1=NC2=C(C=NN2C3=CC=C(C=C3)Cl)C(=O)N1C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B9BP6E	3-(5-(4-Chlorophenyl)-6-methyl-4-oxo-4,5-dihydropyrazolo[3,4-d]pyrimidin-1-yl)benzenesulfonamide	Investigative	23655076	C18H14ClN5O3S	415.9	CC1=NC2=C(C=NN2C3=CC(=CC=C3)S(=O)(=O)N)C(=O)N1C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B9SB3C	N-(4-Chloro-2-((1,3-dioxoisoindolin-2-yl)methyl)phenyl)pyridazine-3-carboxamide	Investigative	44441376	C20H13ClN4O3	392.8	C1=CC=C2C(=C1)C(=O)N(C2=O)CC3=C(C=CC(=C3)Cl)NC(=O)C4=NN=CC=C4	EC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	B9UZL3	(2R,4R)-4-Amino-1-(3,4-dichloro-benzyl)-pyrrolidine-2,4-dicarboxylic acid	Investigative	44302687	C13H14Cl2N2O4	333.16	C1[C@@H](N(C[C@]1(C(=O)O)N)CC2=CC(=C(C=C2)Cl)Cl)C(=O)O	IC50 = 99000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BA20CJ	4-(Amino-carboxy-methyl)-2-hydroxy-3-methyl-benzoic Acid	Investigative	9815955	C10H11NO5	225.2	CC1=C(C=CC(=C1O)C(=O)O)C(C(=O)O)N	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BAB83Q	4-[Amino(carboxy)methyl]-3-methylbenzoic acid	Investigative	3931705	C10H11NO4	209.2	CC1=C(C=CC(=C1)C(=O)O)C(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BAD83C	9-Cyclopropylamino-3-(4''-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11660540	C20H18N4OS	362.4	CCC1=CC=C(C=C1)N2C=NC3=C(C2=O)SC4=NC=CC(=C34)NC5CC5	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BAKQ34	N-(4-Bromo-2-((4,5-dimethoxy-1,3-dioxoisoindolin-2-yl)methyl)phenyl)picolinamide	Investigative	44441363	C23H18BrN3O5	496.3	COC1=C(C2=C(C=C1)C(=O)N(C2=O)CC3=C(C=CC(=C3)Br)NC(=O)C4=CC=CC=N4)OC	EC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BAR71Q	2-(4-Chloroanilino)-7-propyl-7,8-dihydro-6H-quinazolin-5-one	Investigative	71812962	C17H18ClN3O	315.8	CCCC1CC2=NC(=NC=C2C(=O)C1)NC3=CC=C(C=C3)Cl	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BCD6I9	(2S)-2-Amino-4-(4-oxo-1,2,5-thiadiazol-3-yl)butanoic acid	Investigative	10465478	C6H9N3O3S	203.22	C(C[C@@H](C(=O)O)N)C1=NSNC1=O	EC50 = 190000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BCRM32	5-(4-Ethylphenyl)-N,N-dimethyl-6-oxo-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-13-amine oxide	Investigative	11639210	C19H18N4O2S	366.4	CCC1=CC=C(C=C1)N2C=NC3=C(C2=O)SC4=NC=CC(=C34)[N+](C)(C)[O-]	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BD6XI1	6,6-Dimethyl-2-(4-methylanilino)-7,8-dihydroquinazolin-5-one	Investigative	71813137	C17H19N3O	281.35	CC1=CC=C(C=C1)NC2=NC=C3C(=N2)CCC(C3=O)(C)C	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BDX52N	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-butyl-cyclopropanecarboxylic acid	Investigative	44328753	C24H27NO5	409.5	CCCC[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BE60YZ	9-Dimethylamino-3-cyclopentylmethyl-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11631279	C17H20N4OS	328.4	CN(C)C1=C2C3=C(C(=O)N(C=N3)CC4CCCC4)SC2=NC=C1	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BEH2D3	Methyl (1S,5R)-3-hydroxy-3-(2-imidazo[1,2-a]pyridin-2-ylethynyl)-8-azabicyclo[3.2.1]octane-8-carboxylate	Investigative	72545554	C18H19N3O3	325.4	COC(=O)N1[C@@H]2CC[C@H]1CC(C2)(C#CC3=CN4C=CC=CC4=N3)O	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BEI29J	5-(4-Hydroxyphenyl)-6-methyl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	15207262	C18H14N4O2	318.3	CC1=NC2=C(C=NN2C3=CC=CC=C3)C(=O)N1C4=CC=C(C=C4)O	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BF13NL	5-(4-Chlorophenyl)-6-methyl-1-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	44442434	C17H12ClN5O	337.8	CC1=NC2=C(C=NN2C3=CN=CC=C3)C(=O)N1C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BF7C8Z	2-[(3,5-Dimethylphenyl)amino]-6,7,8-trihydroquinazolin-5-one	Investigative	665694	C16H17N3O	267.33	CC1=CC(=CC(=C1)NC2=NC=C3C(=N2)CCCC3=O)C	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BFAO62	9-Dimethylamino-3-cyclohexylmethyl-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11681681	C18H22N4OS	342.5	CN(C)C1=C2C3=C(C(=O)N(C=N3)CC4CCCCC4)SC2=NC=C1	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BFI46N	N-(2-((1,3-Dioxoisoindolin-2-yl)methyl)-3-fluorophenyl)picolinamide	Investigative	44441357	C21H14FN3O3	375.4	C1=CC=C2C(=C1)C(=O)N(C2=O)CC3=C(C=CC=C3F)NC(=O)C4=CC=CC=N4	EC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BH3E4M	(S)-4-((1-Carboxyethyl)amino)benzoic acid	Investigative	22884216	C10H11NO4	209.2	C[C@@H](C(=O)O)NC1=CC=C(C=C1)C(=O)O	IC50 = 195000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BI29NF	9-Dimethylamino-3-(o-hydroxyphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11695769	C17H14N4O2S	338.4	CN(C)C1=C2C3=C(C(=O)N(C=N3)C4=CC=CC=C4O)SC2=NC=C1	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BIGT98	(1R,2S,4R,5R)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid	Investigative	10775369	C8H11NO4	185.18	C1[C@@H]2C[C@]([C@H]1[C@@H]2C(=O)O)(C(=O)O)N	EC50 = 57000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BIJ35Z	9-(N,N-Dimethyl-N-oxyamino)-3-(N-hexamethyleneiminyl)-3H-5-thia-1,3,6-triaza-fluoren-4-one	Investigative	11537767	C17H21N5O2S	359.4	C[N+](C)(C1=C2C3=C(C(=O)N(C=N3)N4CCCCCC4)SC2=NC=C1)[O-]	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BJ59AS	Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaS,1S,2R)-	Investigative	17758554	C5H9NO5S	195.2	C1[C@H]([C@@H]1S(=O)(=O)O)[C@@H](C(=O)O)N	Ki = 81000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BJ63VK	13-(Dimethylamino)-5-(4-ethylphenyl)-8-oxa-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one	Investigative	11652895	C19H18N4O2	334.4	CCC1=CC=C(C=C1)N2C=NC3=C(C2=O)OC4=NC=CC(=C34)N(C)C	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BJ9L3T	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-ethyl-cyclopropanecarboxylic acid	Investigative	44329042	C22H23NO5	381.4	CC[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BJNB38	(1S,2S,4S,5R)-2-Amino-bicyclo[2.1.1]hexane-2,5-dicarboxylic acid	Investigative	10560963	C8H11NO4	185.18	C1[C@H]2C[C@]([C@@H]1[C@@H]2C(=O)O)(C(=O)O)N	EC50 = 91000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BKC63B	3-[Amino(carboxy)methyl]bicyclo[1.1.1]pentane-1-carboxylic acid	Investigative	22268047	C8H11NO4	185.18	C1C2(CC1(C2)C(=O)O)C(C(=O)O)N	EC50 = 103000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BL2D6R	5-(4-Ethylphenyl)-13-[2-methoxyethyl(methyl)amino]-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one	Investigative	11581985	C21H22N4O2S	394.5	CCC1=CC=C(C=C1)N2C=NC3=C(C2=O)SC4=NC=CC(=C34)N(C)CCOC	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BL2OD9	6-Methyl-1,5-di(pyrazin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	44442436	C14H10N8O	306.28	CC1=NC2=C(C=NN2C3=NC=CN=C3)C(=O)N1C4=NC=CN=C4	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BLI35O	9-Dimethylamino-3-(2-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11501188	C19H18N4OS	350.4	CCC1=CC=CC=C1N2C=NC3=C(C2=O)SC4=NC=CC(=C34)N(C)C	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BM81BA	9-Dimethylamino-3-benzyl-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	657896	C18H16N4OS	336.4	CN(C)C1=C2C3=C(C(=O)N(C=N3)CC4=CC=CC=C4)SC2=NC=C1	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BNV15U	9-(Dimethylamino)-3-phenylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4(3H)-one	Investigative	699222	C17H14N4OS	322.4	CN(C)C1=C2C3=C(C(=O)N(C=N3)C4=CC=CC=C4)SC2=NC=C1	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BNW01M	5-(4-Chlorophenyl)-1-cycloheptyl-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one	Investigative	44442426	C19H21ClN4O	356.8	CC1=NC2=C(C=NN2C3CCCCCC3)C(=O)N1C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BP3K0E	N-(4-Chloro-2-((4,5-dimethoxy-1,3-dioxoisoindolin-2-yl)methyl)phenyl)picolinamide	Investigative	44441365	C23H18ClN3O5	451.9	COC1=C(C2=C(C=C1)C(=O)N(C2=O)CC3=C(C=CC(=C3)Cl)NC(=O)C4=CC=CC=N4)OC	EC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BP4OD5	9-Dimethylamino-3-cyclobutyl-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11666576	C15H16N4OS	300.4	CN(C)C1=C2C3=C(C(=O)N(C=N3)C4CCC4)SC2=NC=C1	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BPG7E9	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-phenethyl-cyclopropanecarboxylic acid	Investigative	10456810	C28H27NO5	457.5	C1=CC=C(C=C1)CC[C@@H]2[C@@H]([C@H]2C(CC3C4=CC=CC=C4OC5=CC=CC=C35)(C(=O)O)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BQ6J5T	5-(4-Chlorophenyl)-13-(dimethylamino)-8-thia-5,10-diazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one	Investigative	16118680	C18H14ClN3OS	355.8	CN(C)C1=C2C3=C(C(=O)N(C=C3)C4=CC=C(C=C4)Cl)SC2=NC=C1	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BQK1P0	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-methyl-cyclopropanecarboxylic acid	Investigative	44328850	C21H21NO5	367.4	C[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BRSO72	(S)-2-Amino-3-(4-butyl-3-hydroxy-isoxazol-5-yl)-propionic acid	Investigative	10263168	C10H16N2O4	228.24	CCCCC1=C(ONC1=O)C[C@@H](C(=O)O)N	Ki = 97000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BSX63D	(1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-3-isobutyl-cyclopropanecarboxylic acid	Investigative	44329033	C24H27NO5	409.5	CC(C)C[C@@H]1[C@@H]([C@H]1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BU2L0N	9-Dimethylamino-3-(2,4-dichlorophenyl)-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11661106	C17H12Cl2N4OS	391.3	CN(C)C1=C2C3=C(C(=O)N(C=N3)C4=C(C=C(C=C4)Cl)Cl)SC2=NC=C1	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BVL47K	9-N-Azetidinyl-3-(4''-ethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11682046	C20H18N4OS	362.4	CCC1=CC=C(C=C1)N2C=NC3=C(C2=O)SC4=NC=CC(=C34)N5CCC5	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BVM18G	Cyclopropaneacetic acid, alpha-amino-2-sulfo-, (alphaR,1R,2R)-	Investigative	17758449	C5H9NO5S	195.2	C1[C@@H]([C@@H]1S(=O)(=O)O)[C@H](C(=O)O)N	Ki = 55000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BVQG81	N-(4-Bromo-2-((4,5-dimethyl-1,3-dioxoisoindolin-2-yl)methyl)phenyl)picolinamide	Investigative	44441367	C23H18BrN3O3	464.3	CC1=C(C2=C(C=C1)C(=O)N(C2=O)CC3=C(C=CC(=C3)Br)NC(=O)C4=CC=CC=N4)C	EC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BW4FT6	3-Fluoro-5-(6-(1H-pyrazole-1-yl)-4-pyrimidinyl)benzamide	Investigative	122185330	C14H10FN5O	283.26	C1=CN(N=C1)C2=NC=NC(=C2)C3=CC(=CC(=C3)F)C(=O)N	Ki ~ 63095.73 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BW7SR0	9-Dimethylamino-3-cyclopropyl-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11565466	C14H14N4OS	286.35	CN(C)C1=C2C3=C(C(=O)N(C=N3)C4CC4)SC2=NC=C1	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BWJ5X2	2-(2-Chloroanilino)-7-methyl-7,8-dihydro-6H-quinazolin-5-one	Investigative	73349072	C15H14ClN3O	287.74	CC1CC2=NC(=NC=C2C(=O)C1)NC3=CC=CC=C3Cl	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BWPB96	9-Dimethylamino-3-(p-trifluoromethylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11560185	C18H13F3N4OS	390.4	CN(C)C1=C2C3=C(C(=O)N(C=N3)C4=CC=C(C=C4)C(F)(F)F)SC2=NC=C1	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BX01QM	5-(4-Ethylphenyl)-13-(2,2,2-trifluoroethylamino)-8-thia-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(13),2(7),3,9,11-pentaen-6-one	Investigative	11582178	C19H15F3N4OS	404.4	CCC1=CC=C(C=C1)N2C=NC3=C(C2=O)SC4=NC=CC(=C34)NCC(F)(F)F	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BXEV80	9-Dimethylamino-3-(1H-indazol-6-yl)-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11537814	C18H14N6OS	362.4	CN(C)C1=C2C3=C(C(=O)N(C=N3)C4=CC5=C(C=C4)C=NN5)SC2=NC=C1	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BXO13N	9-Dimethylamino-3-(4-cyclohexylphenyl)-3H-5-thia-1,3,6-triazafluoren-4-one	Investigative	11682866	C23H24N4OS	404.5	CN(C)C1=C2C3=C(C(=O)N(C=N3)C4=CC=C(C=C4)C5CCCCC5)SC2=NC=C1	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BY1UF5	2-Amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid(HYDIA)	Investigative	44322840	C8H11NO5	201.18	C1[C@H]([C@](C2C1[C@@H]2C(=O)O)(C(=O)O)N)O	Ki ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BZPA02	2-((2-Chlorophenyl)amino)-7,8-dihydroquinazolin-5(6H)-one	Investigative	71743756	C14H12ClN3O	273.72	C1CC2=NC(=NC=C2C(=O)C1)NC3=CC=CC=C3Cl	IC50 ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	BZPS47	L-Homocysteic acid	Investigative	177491	C4H9NO5S	183.19	C(CS(=O)(=O)O)[C@@H](C(=O)O)N	Ki = 54000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	D01EVA	CPCCOEt	Investigative	6278000	C13H13NO4	247.25	CCOC(=O)C12CC1/C(=N\\O)/C3=CC=CC=C3O2	Ki ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	D06PAK	LY-389795	Investigative	10058694	C7H9NO4S	203.22	C1[C@](C2[C@H](C2S1)C(=O)O)(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	D07GRG	LY-379268	Investigative	10197984	C7H9NO5	187.15	C1[C@]([C@@H]2[C@H]([C@@H]2O1)C(=O)O)(C(=O)O)N	Ki ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	D09UBS	Ro64-5229	Investigative	10428048	C17H19Cl2N3O	352.3	C1CCCC(CC1)O/C(=C\\N2C=NC=N2)/C3=C(C=CC=C3Cl)Cl	Ki ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	D0EK6P	(2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate	Investigative	5310984	C6H10N2O4	174.15	C1[C@@H](NC[C@]1(C(=O)O)N)C(=O)O	Ki ~ 100000 nM	Poor binder
T99347	Metabotropic glutamate receptor 5	D0W0NJ	PMID17532216C2f	Investigative	44442431	C18H14ClN5O3S	415.9	CC1=NC2=C(C=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(=O)N1C4=CC=C(C=C4)Cl	IC50 ~ 100000 nM	Poor binder