Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T43721 | Target Info | |||
| Target Name | Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) | ||||
| Synonyms |
NAD-dependent 11-beta-hydroxysteroid dehydrogenase; HSD11B2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-beta-HSD2; 11-DH2; 11 beta-hydroxysteroid dehydrogenase type 2; 11 beta-HSD2
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | HSD11B2 | ||||
| Biochemical Class | Short-chain dehydrogenases reductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 66 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-({1-[4-(5-Trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclopentanecarbonyl}-amino)-adamantane-1-carboxylic acid amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL373792; BDBM50195286
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|
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
4-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]amino]-N-[[4-(methylsulfonylcarbamoyl)phenyl]methyl]adamantane-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246056; SCHEMBL1047013
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|
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
{(1R,4S,5R,7S)-4-[2-(4-Chloro-phenoxy)-2-methyl-propionylamino]-adamantan-1-yl}-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220414; BDBM50192801
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| Activity |
IC50 = 52000 nM
|
[3] | |||
| Compound Name |
N-[(1R,2S,5S,7S)-5-(5-Amino-4H-[1,2,4]triazol-3-yl)-adamantan-2-yl]-2-(4-chloro-phenoxy)-2-methyl-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219136; BDBM50192787
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| Activity |
IC50 = 55000 nM
|
[3] | |||
| Compound Name |
2-[3-(2-Fluoro-phenoxy)-azetidin-1-yl]-N-(5-hydroxy-adamantan-2-yl)-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217917; BDBM50202093
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| Activity |
IC50 = 56000 nM
|
[4] | |||
| Compound Name |
2-Methyl-2-phenoxy-N-(5-sulfamoyl-adamantan-2-yl)-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241719; BDBM50197401
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|
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| Activity |
IC50 = 59000 nM
|
[5] | |||
| Compound Name |
2-(4-Chloro-phenoxy)-N-(5-dimethylsulfamoyl-adamantan-2-yl)-2-methyl-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246442; SCHEMBL1046451; BDBM50197406
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| Activity |
IC50 = 60000 nM
|
[5] | |||
| Compound Name |
N-[(1R,3S)-5-Hydroxy-2-adamantyl]-2-(6,7,9,10-tetrahydro-8H-[1,3]dioxolo[4,5-g][3]benzazepin-8-yl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374728; SCHEMBL232914; BDBM50202087
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|
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| Activity |
IC50 = 62000 nM
|
[4] | |||
| Compound Name |
2-(4-Chloro-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241716; SCHEMBL2824373; BDBM50197405
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|
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| Activity |
IC50 = 65000 nM
|
[5] | |||
| Compound Name |
4-{2-[4-(5-Trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-butyrylamino}-adamantane-1-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220153; SCHEMBL231875; BDBM50195293
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|
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| Activity |
IC50 = 65000 nM
|
[1] | |||
| Compound Name |
Chembl373601
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3085038; BDBM50192673; 2-(4-chloro-phenoxy)-N-(1-hydroxy-2-oxa-tricyclo[3.3.1.13,7]dec-6-yl)-2-methyl-propionamide; 2-(4-chlorophenoxy)-N-(1-hydroxy-2-oxatricyclo[3.3.1.1~3,7~]dec-6-yl)-2-methylpropanamide
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|
||||
| Activity |
IC50 = 70000 nM
|
[6] | |||
| Compound Name |
2-(4-Chloro-phenoxy)-2-methyl-N-(5-methylsulfamoyl-adamantan-2-yl)-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL392913; SCHEMBL1077064; BDBM50197419
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|
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| Activity |
IC50 = 85000 nM
|
[5] | |||
| Compound Name |
4-(2-Methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[2.2.2]octane-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218247; BDBM50192674
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|
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| Activity |
IC50 = 90000 nM
|
[6] | |||
| Compound Name |
4-[3,3-Dimethyl-2-oxo-4-(5-trifluoromethyl-pyridin-2-yloxymethyl)-pyrrolidin-1-yl]-adamantane-1-carboxamidine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL376226; SCHEMBL328850; BDBM50193791
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|
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| Activity |
IC50 = 90000 nM
|
[7] | |||
| Compound Name |
N-[(1S)-5-(2-Amino-2-oxoethyl)-2-adamantyl]-2-methyl-2-(5-morpholin-4-ylpyridin-2-yl)oxypropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216976; BDBM50192786
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-(2-Adamantyl)-2-[4-(3-cyanopyridin-2-yl)piperazin-1-yl]acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384364; SCHEMBL4009552; BDBM50202091; N-adamantan-2-yl-2-[4-(3-cyano-pyridin-2-yl)-piperazin-1-yl]-acetamide
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-[2-(3,3-Difluoro-piperidin-1-yl)-butyrylamino]-adamantane-1-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL223083; BDBM50195303
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|
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
N-(5-Methanesulfonyl-adamantan-2-yl)-2-methyl-2-(2-trifluoromethyl-phenoxy)-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393167; BDBM50197403
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S)-2-[(3R)-3-Fluoropyrrolidin-1-yl]-N-(5-hydroxy-2-adamantyl)propanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218758
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-{2-Cyclopropyl-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-acetylamino}-adamantane-1-carboxylic acid amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222618; SCHEMBL234510; BDBM50195301
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-((1R,2S,5R,7S)-5-Carbamoylmethyl-adamantan-2-yl)-2-methyl-2-[5-(4-methyl-piperazin-1-yl)-pyridin-2-yloxy]-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216977; BDBM50192794
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[[4-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]amino]-1-adamantyl]methoxy]acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246677
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-(2-Chloro-4-fluoro-phenoxy)-2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL391652; SCHEMBL1044990; BDBM50197416
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-(5-Hydroxy-adamantan-2-yl)-2-(3-trifluoromethyl-pyrrolidin-1-yl)-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375341; BDBM50202094
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(1-Hydroxy-adamantan-2-yl)-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218143; BDBM50202098
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-[(E)-5-Fluoro-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218358; CHEMBL386029; N-[(Z)-5-fluoro-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide; SCHEMBL230352; BDBM50202092; BDBM50202099
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-(1-Adamantyl)-3-[(1S,4S,5R,9S,10R,13S)-5,9-dimethyl-14-methylidene-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402453; BDBM50436977
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|
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Spiro-carboxamide scaffold, 5
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL554502; BDBM29832
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|
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2R)-3,3,3-Trifluoro-2-[5-[(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl]sulfonylthiophen-2-yl]-2-hydroxypropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323021; SCHEMBL3628001; HSD-621; BDBM50426478
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|
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-Phenyl-N-(5-sulfamoyl-adamantan-2-yl)-isobutyramide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL391447; BDBM50197411
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
4-{2-[4-(5-Trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-butyrylamino}-adamantane-1-carboxylic acid amide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374110; SCHEMBL231709; BDBM50195302
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3r,9r)-9-(2-(4-Chlorophenoxy)-2-methylpropanamido)bicyclo[3.3.1]nonane-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219448; CHEMBL255148; BDBM50192679; BDBM50411944
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
CID 57418438
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322705; SCHEMBL3222072; BDBM50426475
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|
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(7r,9r)-9-(2-(4-Chlorophenoxy)-2-methylpropanamido)-3-oxa-bicyclo[3.3.1]nonane-7-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL376272; BDBM50192675
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
4-({1-[4-(5-Trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-cyclopropanecarbonyl}-amino)-adamantane-1-carboxylic acid amide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL223804; CHEMBL376293; SCHEMBL232750; BDBM50195287; BDBM50195292
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(3r,9r)-9-(2-Methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[3.3.1]nonane-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219403; CHEMBL384426; BDBM50192672; BDBM50192683
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-((1R,2S,5R,7S)-5-Carbamoylmethyl-adamantan-2-yl)-2-(5-cyano-pyridin-2-yloxy)-2-methyl-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL385176; BDBM50192785
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-((1R,2S,5R,7S)-5-Carbamoylmethyl-adamantan-2-yl)-2-(6-methylamino-pyridin-3-yl)-isobutyramide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL219081; BDBM50192795
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-Cyclohexyl-3-[(1R,4S,5R,9R,10S,11S,13R,15R)-11,15-dihydroxy-5,9-dimethyl-14-methylidene-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402464; BDBM50436982
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
1-{[(3R)-3-Methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL460962; SCHEMBL3953157; BDBM50248569; DB07624; Q27096844
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Spiro-carboxamide scaffold, 13
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL557417; SCHEMBL19248197; BDBM29840
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|
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-((1R,2S,5R,7S)-5-Carbamoylmethyl-adamantan-2-yl)-2-methyl-2-(5-pyrazol-1-yl-pyridin-2-yloxy)-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL219348; BDBM50192792
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N-((1R,2S,5R,7S)-5-Carbamoylmethyl-adamantan-2-yl)-2-(5-cyano-pyridin-2-yl)-isobutyramide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219349; BDBM50192798
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-(2-(4-Chlorophenoxy)-2-methylpropanamido)bicyclo[2.2.2]octane-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219606; SCHEMBL19248176; BDBM50192686
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|
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| Activity |
IC50 = 100000 nM
|
[6] | |||
| Compound Name |
3-{(1R,4S,5R,7S)-4-[2-(4-Chloro-phenoxy)-2-methyl-propionylamino]-adamantan-1-yl}-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219028; BDBM50192793
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|
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| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
(3s,9s)-9-(2-(5-Cyanopyridin-2-yloxy)-2-methylpropanamido)bicyclo[3.3.1]nonane-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219295; BDBM50192684
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-[(1R,2S,5S,7S)-5-(5-Amino-4-cyano-oxazol-2-yl)-adamantan-2-yl]-2-(4-chloro-phenoxy)-2-methyl-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219575; BDBM50192796
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Caloncobic acid A
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2035568; BDBM50384886
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|
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(3r,9r)-9-(2-Methyl-2-(4-(5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)propanamido)bicyclo[3.3.1]nonane-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374409; BDBM50192676
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Spiro-carboxamide scaffold, 6
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL562614; BDBM29833
Click to Show/Hide
|
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[(E)-5-Hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219142; CHEMBL373889; N-[(Z)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}acetamide; SCHEMBL232315; SCHEMBL19256010; SCHEMBL20457230; BDBM50202086; BDBM50202089
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-((1R,2S,5R,7S)-5-Carbamoylmethyl-adamantan-2-yl)-2-(6-morpholin-4-yl-pyridin-3-yl)-isobutyramide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375979; BDBM50192799
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
1-[(1R,4S,5R,9R,10S,11S,13R,15R)-11,15-Dihydroxy-5,9-dimethyl-14-methylidene-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]-3-(4-fluorophenyl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402458; BDBM50436984
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[(E)-5-Hydroxy-2-adamantyl]-2-{4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375156; SCHEMBL234406; SCHEMBL19256180; BDBM50202102; N-(5-Hydroxy-adamantan-2-yl)-2-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-propionamide
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-(4-Chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(N-hydroxycarbamimidoyl)-adamantan-2-yl]-2-methyl-propionamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375744; BDBM50192790
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|
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| Activity |
IC50 = 100000 nM
|
[3] | |||
| Compound Name |
9-(4-{[(5-Cyanopyridin-2-yl)oxy]methyl}-3,3-dimethyl-2-oxopyrrolidin-1-yl)bicyclo[3.3.1]nonane-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL218119; CHEMBL221284; SCHEMBL328938; BDBM50193785; BDBM50193788
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
1-[(1S,4S,5R,9S,10R,13S)-5,9-Dimethyl-14-methylidene-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]-3-(4-fluorophenyl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402452; BDBM50436978
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-(4-Chlorophenoxy)-N-(5-cyanocyclooctyl)-2-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL387010; BDBM50192671
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(2R)-2-[(3R)-3-Fluoropyrrolidin-1-yl]-N-(5-hydroxy-2-adamantyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL415429; SCHEMBL234728
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
CID 49846838
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323017; SCHEMBL3629343; BDBM50426484
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-(4-Chloro-phenoxy)-2-methyl-N-[(1S,2S,5R,7S)-5-(1H-tetrazol-5-ylmethyl)-adamantan-2-yl]-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424931; BDBM50192789
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(1R,4S,5R,9R,10S,11S,13R,15R)-15-Hydroxy-5,9-dimethyl-14-methylidene-11-methylsulfanylcarbothioyloxytetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402473; BDBM50436980
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Spiro-carboxamide scaffold, 3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL564652; BDBM29830
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-(4-Fluoro-2-methoxy-phenoxy)-N-(5-methanesulfonyl-adamantan-2-yl)-2-methyl-propionamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL240622; BDBM50197400
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
1-Piperidin-1-yl-cyclopropanecarboxylic acid (5-hydroxy-adamantan-2-yl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220102; CHEMBL221159; SCHEMBL233173; BDBM50195289; BDBM50195297
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
HSD Inhibitor 23
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424937; SCHEMBL233462; CTK8E9791; DTXSID80469772; BDBM50202097
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 45 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-(4-chlorophenyl)-2-(phenylsulfonyl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-(4-Chlorophenyl)-2-(phenylsulfonyl)ethanone; 38488-19-6; CHEMBL238834; 1-(4-chlorophenyl)-2-(phenylsulfonyl)-1-ethanone; 4-Chlorophenacylphenyl sulfone; AC1LBPW5; SCHEMBL10931021; ZINC58239; CTK6G9147; MolPort-002-876-864; KZACHGLUJYSTGQ-UHFFFAOYSA-N; BDBM50212531; CCG-43075; AKOS003310153; MCULE-9299558448; 7H-330S; KS-00001Z91; ST50308734; Ethanone, 1-(4-chlorophenyl)-2-phenylsulfonyl-; 4'-CHLORO-2(PHENYL SULFONYL)ACETOPHENONE; 2-(benzenesulfonyl)-1-(4-chlorophenyl)ethanone; AF-731/00081054
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
2-(phenylsulfonyl)-1-p-tolylethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
38488-14-1; CHEMBL392808; Ethanone, 1-(4-methylphenyl)-2-(phenylsulfonyl)-; 2-(phenylsulfonyl)-1-p-tolylethanone; 4-Methylphenacylphenyl sulfone; SCHEMBL6202982; CTK1A8876; DTXSID20575987; BDBM50212530; ZINC28874639; AKOS008967833; 1-p-Tolyl-2-(phenylsulphonyl)ethanone; 1-(4-methylphenyl)-2-(phenylsulfonyl)ethanone; 2-(Benzenesulfonyl)-1-(4-methylphenyl)ethan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
1-(3-methoxyphenyl)-2-(phenylsulfonyl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393079; 1-(3-methoxyphenyl)-2-(phenylsulfonyl)ethanone; BDBM50212534
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
1-(4-methoxyphenyl)-2-(phenylsulfonyl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238620; 27918-37-2; 1-(4-methoxyphenyl)-2-(phenylsulfonyl)ethanone; 1-(4-methoxyphenyl)-2-(phenylsulfonyl)-1-ethanone; AC1N74YZ; Oprea1_356612; 2-(benzenesulfonyl)-1-(4-methoxyphenyl)ethanone; SCHEMBL6203408; CTK0J2325; DTXSID00401432; MolPort-002-876-892; ZINC399878; KS-00003CN3; BDBM50212535; AKOS005097711; 7H-365S; MCULE-5138703884; 4'-Methoxy-alpha-(phenylsulfonyl)acetophenone; 4'-METHOXY-2-(PHENYLSULFONYL)ACETOPHENONE; Ethanone, 1-(4-methoxyphenyl)-2-(phenylsulfonyl)-
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
1-(4-fluorophenyl)-2-(phenylsulfonyl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238832; 41024-58-2; Ethanone, 1-(4-fluorophenyl)-2-(phenylsulfonyl)-; 1-(4-fluorophenyl)-2-(phenylsulfonyl)-1-ethanone; 1-(4-fluorophenyl)-2-(phenylsulfonyl)ethanone; AC1LS74Y; CTK1D4107; DTXSID90363277; MolPort-002-876-867; ZINC1396918; BDBM50212525; AKOS005098035; MCULE-9386710722; 7H-334S; KS-00001Z92; 4'-Fluoro-alpha-(phenylsulfonyl)acetophenone; 2-(benzenesulfonyl)-1-(4-fluorophenyl)ethanone
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
N-(4-Phenyloxazol-2-yl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL425022; BDBM50167721; N-(4-Phenyl-oxazol-2-yl)-benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[14] | |||
| Compound Name |
3-Chloro-2-methyl-N-(4-phenyl-oxazol-2-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371074; BDBM50167717
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[14] | |||
| Compound Name |
3-Chloro-N-(4-(4-cyanophenyl)oxazol-2-yl)-2-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL196782; BDBM50167723; 3-Chloro-N-[4-(4-cyano-phenyl)-oxazol-2-yl]-2-methyl-benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[14] | |||
| Compound Name |
N-(4-Biphenyl-4-yl-oxazol-2-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL197151; BDBM50167720
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[14] | |||
| Compound Name |
2-(Benzenesulfonyl)-1-[4-(trifluoromethyl)phenyl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL383146; SCHEMBL12577229; BDBM50167718; 2-Benzenesulfonyl-1-(4-trifluoromethyl-phenyl)-ethanone; 2-(phenylsulfonyl)-1-(4-(trifluoromethyl)phenyl)ethanone
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
N-(4-(4-(Trifluoromethyl)phenyl)oxazol-2-yl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL383820; BDBM50167716; N-[4-(4-Trifluoromethyl-phenyl)-oxazol-2-yl]-benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[14] | |||
| Compound Name |
2-(2-(3-Chloro-2-methylphenylsulfonamido)thiazol-4-yl)-N,N-diethylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BVT-14225; CHEMBL341324; 2-(2-((3-chloro-2-methylphenyl)sulfonamido)thiazol-4-yl)-N,N-diethylacetamide; SCHEMBL677390; ZINC595364; BCP20746; BVT14225; BDBM50117901; MFCD25976913; AKOS027252897; CS-6341; BVT 14225;BVT14225; AS-47019; HY-18055
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[13] | |||
| Compound Name |
N-[4-(4,5-Dimethyl-oxazol-2-ylsulfamoyl)-phenyl]-N-methyl-acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372623; BDBM50167724
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[14] | |||
| Compound Name |
(1R,4S,5R,9R,10S,11S,13R,15R)-11-Acetyloxy-15-hydroxy-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402475; BDBM50436979
Click to Show/Hide
|
||||
| Activity |
IC50 = 228700 nM
|
[8] | |||
| Compound Name |
(3S,5R,8R,9R,10R,12R,13R,14R)-3,12-Dihydroxy-4,4,8,10,14-pentamethyl-1,2,3,5,6,7,9,11,12,13-decahydrocyclopenta[a]phenanthren-15-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422415; BDBM50080411
Click to Show/Hide
|
||||
| Activity |
IC50 = 283600 nM
|
[15] | |||
| Compound Name |
[(3S,5R,8R,9R,10R,12R,13S,14R,17R)-3,17-Dihydroxy-4,4,8,10,14-pentamethyl-15-oxo-1,2,3,5,6,7,9,11,12,13,16,17-dodecahydrocyclopenta[a]phenanthren-12-yl] acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422266; BDBM50080412
Click to Show/Hide
|
||||
| Activity |
IC50 = 299600 nM
|
[15] | |||
| Compound Name |
(1S,5R)-1-(1,3-Benzothiazol-2-ylsulfanylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764012; BDBM50145445
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,5R)-1-[(5-Ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfonylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763512; BDBM50145436
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,5R)-N-[(2E)-3,7-Dimethylocta-2,6-dienyl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763187; BDBM50145444
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,5R)-N-[(3,5-Difluorophenyl)methyl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765258; BDBM50145441
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,5R)-1-(Naphthalen-2-ylsulfonylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764124; BDBM50145438
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,5R)-1-(1,3-Benzothiazol-2-ylsulfonylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764356; BDBM50145433
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,5R)-1-(1,3-Benzoxazol-2-ylsulfanylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765604; BDBM50145446
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,5R)-1-[(5-Hexylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764965; BDBM50145447
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
1,1-Dioxo-2-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]-1,2-benzothiazol-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763599; BDBM50145429
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,5R)-1-[(1-Phenyltetrazol-5-yl)sulfonylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763813; BDBM50145437
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
4-[(3-Chlorophenylsulfonamido)methyl]-N-cycloheptyl-N-propylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL551949; SCHEMBL19256187; BDBM50297910
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[17] | |||
| Compound Name |
4-Methoxy-N-[[1-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]triazol-4-yl]methyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764563; BDBM50145432
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
4-[(3-Chlorophenylsulfonamido)methyl]-N-(1-adamantyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559418; BDBM50297912
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[17] | |||
| Compound Name |
2-[[(1S,5R)-8-Oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]isoindole-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765656; BDBM50145430
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,5R)-1-[(1-Phenyltetrazol-5-yl)sulfanylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764025; BDBM50145449
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,5R)-N-[5-(4-Chlorophenyl)-1,3-thiazol-2-yl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764221; BDBM50145439
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,4S,5R,9S,10R,13S,14R)-14-Hydroxy-14-(hydroxymethyl)-5,9-dimethyltetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490353; BDBM50436975
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[8] | |||
| Compound Name |
(1S,5R)-1-(Naphthalen-2-ylsulfanylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764111; BDBM50145450
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,5R)-1-[(5-Hexylsulfanyl-1,3,4-thiadiazol-2-yl)sulfonylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765510; BDBM50145435
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,5R)-8-Oxo-4-propan-2-yl-N-(2-thiophen-2-ylethyl)spiro[4.5]deca-3,9-diene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765590; BDBM50145440
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,5R)-N-[(6,6-Dimethyl-2-bicyclo[3.1.1]heptanyl)methyl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765321; BDBM50145443
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
Tert-butyl N-[[1-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]triazol-4-yl]methyl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764151; BDBM50145431
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
4-Amino-N-[[1-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]triazol-4-yl]methyl]-N-pyrimidin-2-ylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764299; BDBM50145428
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
1-[(1R,4S,5R,9R,10S,11S,13R,15R)-11,15-Dihydroxy-5,9-dimethyl-14-methylidene-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]-3-phenylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402457; BDBM50436985
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[8] | |||
| Compound Name |
N-Butyl-4-[(3-chlorophenylsulfonamido)methyl]-N-cycloheptylbenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL550065; BDBM50297911
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[17] | |||
| Compound Name |
(1S,4S,5R,9S,10R,13S,14R)-5,14-Bis(hydroxymethyl)-5,9-dimethyltetracyclo[11.2.1.01,10.04,9]hexadecan-14-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2402471; BDBM50436976
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[8] | |||
| Compound Name |
(1S,5R)-1-(1,3-Benzoxazol-2-ylsulfonylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763513; BDBM50145434
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,5R)-N-[1-(1-Adamantyl)ethyl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3765140; BDBM50145442
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Compound Name |
(1S,5R)-1-[(5-Ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3764520; BDBM50145448
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|
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| Activity |
IC50 > 1000000 nM
|
[16] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5958-62. | ||||
| REF 2 | Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation. Bioorg Med Chem Lett. 2007 Feb 1;17(3):750-5. | ||||
| REF 3 | Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5414-9. | ||||
| REF 4 | Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors. J Med Chem. 2007 Jan 11;50(1):149-64. | ||||
| REF 5 | Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors. Bioorg Med Chem Lett. 2007 Jan 15;17(2):527-32. | ||||
| REF 6 | Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5408-13. | ||||
| REF 7 | Discovery of orally active butyrolactam 11beta-HSD1 inhibitors. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5555-60. | ||||
| REF 8 | Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11-HSD1 inhibitors: potential impact in diabetes. Eur J Med Chem. 2013 Jul;65:403-14. | ||||
| REF 9 | Discovery and structure-guided drug design of inhibitors of 11beta-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3682-5. | ||||
| REF 10 | Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2012 Nov 23;4(1):118-23. | ||||
| REF 11 | Synthesis and optimization of arylsulfonylpiperazines as a novel class of inhibitors of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1). Bioorg Med Chem Lett. 2009 Mar 1;19(5):1522-7. | ||||
| REF 12 | Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11beta-hydroxysteroid dehydrogenases. J Nat Prod. 2012 Apr 27;75(4):599-604. | ||||
| REF 13 | beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action. Bioorg Med Chem. 2007 Jul 1;15(13):4396-405. | ||||
| REF 14 | Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2865-9. | ||||
| REF 15 | Hupehenols A-E, selective 11-hydroxysteroid dehydrogenase type 1 (11-HSD1) inhibitors from Viburnum hupehense. J Nat Prod. 2015 Feb 27;78(2):330-4. | ||||
| REF 16 | Synthesis and evaluation of colletoic acid core derivatives. Eur J Med Chem. 2016 Mar 3;110:126-32. | ||||
| REF 17 | 4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabeti... Bioorg Med Chem Lett. 2009 Aug 1;19(15):4455-8. | ||||
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