TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T43721	Corticosteroid 11-beta-dehydrogenase 2	B1CJH7	(1S,5R)-1-(1,3-Benzothiazol-2-ylsulfanylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one	Investigative	127042478	C21H23NOS2	369.5	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CSC3=NC4=CC=CC=C4S3	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B1T8NI	(1S,5R)-1-[(5-Ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfonylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one	Investigative	127042099	C25H28N4O3S	464.6	CCN1C2=CC=CC=C2C3=C1N=C(N=N3)S(=O)(=O)C[C@H]4CC=C([C@@]45CCC(=O)C=C5)C(C)C	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B3M4YS	(1S,5R)-N-[(2E)-3,7-Dimethylocta-2,6-dienyl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide	Investigative	127042780	C24H35NO2	369.5	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)C(=O)NC/C=C(\\C)/CCC=C(C)C	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B3TS9X	(1S,5R)-N-[(3,5-Difluorophenyl)methyl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide	Investigative	127040565	C21H23F2NO2	359.4	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)C(=O)NCC3=CC(=CC(=C3)F)F	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B3W0XM	(1S,5R)-1-(Naphthalen-2-ylsulfonylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one	Investigative	127041811	C24H26O3S	394.5	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CS(=O)(=O)C3=CC4=CC=CC=C4C=C3	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B3X8UP	(1S,5R)-1-(1,3-Benzothiazol-2-ylsulfonylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one	Investigative	127042102	C21H23NO3S2	401.5	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CS(=O)(=O)C3=NC4=CC=CC=C4S3	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B4JT9G	(1S,5R)-1-(1,3-Benzoxazol-2-ylsulfanylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one	Investigative	127042477	C21H23NO2S	353.5	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CSC3=NC4=CC=CC=C4O3	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B4M3GI	(1S,5R)-1-[(5-Hexylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one	Investigative	127040906	C22H32N2OS3	436.7	CCCCCCSC1=NN=C(S1)SC[C@H]2CC=C([C@@]23CCC(=O)C=C3)C(C)C	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B5IO6U	(1R,4S,5R,9R,10S,11S,13R,15R)-11-Acetyloxy-15-hydroxy-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid	Investigative	73355072	C22H32O5	376.5	CC(=O)O[C@H]1C[C@H]2C[C@]3([C@@H]1[C@@]4(CCC[C@@]([C@H]4CC3)(C)C(=O)O)C)[C@@H](C2=C)O	IC50 = 228700 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B5UJC2	N-(4-Phenyloxazol-2-yl)benzenesulfonamide	Investigative	44402393	C15H12N2O3S	300.3	C1=CC=C(C=C1)C2=COC(=N2)NS(=O)(=O)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B8LH4K	1,1-Dioxo-2-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]-1,2-benzothiazol-3-one	Investigative	127040901	C21H23NO4S	385.5	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CN3C(=O)C4=CC=CC=C4S3(=O)=O	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B9E2OB	(1S,5R)-1-[(1-Phenyltetrazol-5-yl)sulfonylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one	Investigative	127038197	C21H24N4O3S	412.5	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CS(=O)(=O)C3=NN=NN3C4=CC=CC=C4	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	B9G5QA	4-[(3-Chlorophenylsulfonamido)methyl]-N-cycloheptyl-N-propylbenzamide	Investigative	44250316	C24H31ClN2O3S	463	CCCN(C1CCCCCC1)C(=O)C2=CC=C(C=C2)CNS(=O)(=O)C3=CC(=CC=C3)Cl	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BA24OC	4-Methoxy-N-[[1-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]triazol-4-yl]methyl]benzenesulfonamide	Investigative	127041808	C24H30N4O4S	470.6	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CN3C=C(N=N3)CNS(=O)(=O)C4=CC=C(C=C4)OC	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BAFC89	4-[(3-Chlorophenylsulfonamido)methyl]-N-(1-adamantyl)benzamide	Investigative	45269430	C24H27ClN2O3S	459	C1C2CC3CC1CC(C2)(C3)NC(=O)C4=CC=C(C=C4)CNS(=O)(=O)C5=CC(=CC=C5)Cl	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BBJC89	3-Chloro-2-methyl-N-(4-phenyl-oxazol-2-yl)-benzenesulfonamide	Investigative	44402534	C16H13ClN2O3S	348.8	CC1=C(C=CC=C1Cl)S(=O)(=O)NC2=NC(=CO2)C3=CC=CC=C3	IC50 > 200000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BBP19D	2-[[(1S,5R)-8-Oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]isoindole-1,3-dione	Investigative	127037875	C22H23NO3	349.4	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CN3C(=O)C4=CC=CC=C4C3=O	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BBZ1W8	(1S,5R)-1-[(1-Phenyltetrazol-5-yl)sulfanylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one	Investigative	127040904	C21H24N4OS	380.5	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CSC3=NN=NN3C4=CC=CC=C4	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BC85HA	(1S,5R)-N-[5-(4-Chlorophenyl)-1,3-thiazol-2-yl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide	Investigative	127041810	C23H23ClN2O2S	427	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)C(=O)NC3=NC=C(S3)C4=CC=C(C=C4)Cl	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BDSG39	(1S,4S,5R,9S,10R,13S,14R)-14-Hydroxy-14-(hydroxymethyl)-5,9-dimethyltetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid	Investigative	13994830	C20H32O4	336.5	C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2CC[C@@H](C3)[C@](C4)(CO)O)(C)C(=O)O	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BE1U2M	(1S,5R)-1-(Naphthalen-2-ylsulfanylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one	Investigative	127040903	C24H26OS	362.5	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CSC3=CC4=CC=CC=C4C=C3	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BETF70	(1S,5R)-1-[(5-Hexylsulfanyl-1,3,4-thiadiazol-2-yl)sulfonylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one	Investigative	127042100	C22H32N2O3S3	468.7	CCCCCCSC1=NN=C(S1)S(=O)(=O)C[C@H]2CC=C([C@@]23CCC(=O)C=C3)C(C)C	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BG0N2M	3-Chloro-N-(4-(4-cyanophenyl)oxazol-2-yl)-2-methylbenzenesulfonamide	Investigative	44402550	C17H12ClN3O3S	373.8	CC1=C(C=CC=C1Cl)S(=O)(=O)NC2=NC(=CO2)C3=CC=C(C=C3)C#N	IC50 > 200000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BG9FB1	N-(4-Biphenyl-4-yl-oxazol-2-yl)-benzenesulfonamide	Investigative	11280328	C21H16N2O3S	376.4	C1=CC=C(C=C1)C2=CC=C(C=C2)C3=COC(=N3)NS(=O)(=O)C4=CC=CC=C4	IC50 > 200000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BI5W1P	2-(Benzenesulfonyl)-1-[4-(trifluoromethyl)phenyl]ethanone	Investigative	11232699	C15H11F3O3S	328.3	C1=CC=C(C=C1)S(=O)(=O)CC(=O)C2=CC=C(C=C2)C(F)(F)F	IC50 > 200000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BIGD26	N-(4-(4-(Trifluoromethyl)phenyl)oxazol-2-yl)benzenesulfonamide	Investigative	11257147	C16H11F3N2O3S	368.3	C1=CC=C(C=C1)S(=O)(=O)NC2=NC(=CO2)C3=CC=C(C=C3)C(F)(F)F	IC50 > 200000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BJP92U	2-(2-(3-Chloro-2-methylphenylsulfonamido)thiazol-4-yl)-N,N-diethylacetamide	Investigative	6918663	C16H20ClN3O3S2	401.9	CCN(CC)C(=O)CC1=CSC(=N1)NS(=O)(=O)C2=C(C(=CC=C2)Cl)C	IC50 > 200000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BLY1I2	(1S,5R)-8-Oxo-4-propan-2-yl-N-(2-thiophen-2-ylethyl)spiro[4.5]deca-3,9-diene-1-carboxamide	Investigative	127040566	C20H25NO2S	343.5	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)C(=O)NCCC3=CC=CS3	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BM51DF	[(3S,5R,8R,9R,10R,12R,13S,14R,17R)-3,17-Dihydroxy-4,4,8,10,14-pentamethyl-15-oxo-1,2,3,5,6,7,9,11,12,13,16,17-dodecahydrocyclopenta[a]phenanthren-12-yl] acetate	Investigative	101911913	C24H38O5	406.6	CC(=O)O[C@@H]1C[C@@H]2[C@]3(CC[C@@H](C([C@@H]3CC[C@]2([C@]4([C@H]1[C@@H](CC4=O)O)C)C)(C)C)O)C	IC50 = 299600 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BMGO03	(1S,5R)-N-[(6,6-Dimethyl-2-bicyclo[3.1.1]heptanyl)methyl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide	Investigative	127037831	C24H35NO2	369.5	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)C(=O)NCC3CCC4CC3C4(C)C	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BP7J2C	(3S,5R,8R,9R,10R,12R,13R,14R)-3,12-Dihydroxy-4,4,8,10,14-pentamethyl-1,2,3,5,6,7,9,11,12,13-decahydrocyclopenta[a]phenanthren-15-one	Investigative	101911914	C22H34O3	346.5	C[C@]12CC[C@@H](C([C@@H]1CC[C@@]3([C@@H]2C[C@H]([C@H]4[C@]3(C(=O)C=C4)C)O)C)(C)C)O	IC50 = 283600 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BPEA36	Tert-butyl N-[[1-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]triazol-4-yl]methyl]carbamate	Investigative	127041809	C22H32N4O3	400.5	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CN3C=C(N=N3)CNC(=O)OC(C)(C)C	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BPKR17	4-Amino-N-[[1-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]triazol-4-yl]methyl]-N-pyrimidin-2-ylbenzenesulfonamide	Investigative	127040902	C27H31N7O3S	533.6	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CN3C=C(N=N3)CN(C4=NC=CC=N4)S(=O)(=O)C5=CC=C(C=C5)N	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BQ25JX	1-[(1R,4S,5R,9R,10S,11S,13R,15R)-11,15-Dihydroxy-5,9-dimethyl-14-methylidene-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]-3-phenylurea	Investigative	73356624	C26H36N2O3	424.6	C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2[C@H](C[C@@H](C3)C(=C)[C@H]4O)O)(C)NC(=O)NC5=CC=CC=C5	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BRG4W7	N-Butyl-4-[(3-chlorophenylsulfonamido)methyl]-N-cycloheptylbenzamide	Investigative	45271081	C25H33ClN2O3S	477.1	CCCCN(C1CCCCCC1)C(=O)C2=CC=C(C=C2)CNS(=O)(=O)C3=CC(=CC=C3)Cl	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BSG4A1	(1S,4S,5R,9S,10R,13S,14R)-5,14-Bis(hydroxymethyl)-5,9-dimethyltetracyclo[11.2.1.01,10.04,9]hexadecan-14-ol	Investigative	73356628	C20H34O3	322.5	C[C@]1(CCC[C@@]2([C@@H]1CC[C@]34[C@H]2CC[C@@H](C3)[C@](C4)(CO)O)C)CO	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BT0A3N	(1S,5R)-1-(1,3-Benzoxazol-2-ylsulfonylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one	Investigative	127042101	C21H23NO4S	385.5	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)CS(=O)(=O)C3=NC4=CC=CC=C4O3	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BU7ZM0	(1S,5R)-N-[1-(1-Adamantyl)ethyl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide	Investigative	127042781	C26H37NO2	395.6	CC(C)C1=CC[C@@H]([C@]12CCC(=O)C=C2)C(=O)NC(C)C34CC5CC(C3)CC(C5)C4	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BW0YJ1	N-[4-(4,5-Dimethyl-oxazol-2-ylsulfamoyl)-phenyl]-N-methyl-acetamide	Investigative	44402662	C14H17N3O4S	323.37	CC1=C(OC(=N1)NS(=O)(=O)C2=CC=C(C=C2)N(C)C(=O)C)C	IC50 > 200000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	BY6X3V	(1S,5R)-1-[(5-Ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one	Investigative	127040905	C25H28N4OS	432.6	CCN1C2=CC=CC=C2C3=C1N=C(N=N3)SC[C@H]4CC=C([C@@]45CCC(=O)C=C5)C(C)C	IC50 > 1000000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	D02KXX	1-(4-chlorophenyl)-2-(phenylsulfonyl)ethanone	Investigative	586971	C14H11ClO3S	294.8	C1=CC=C(C=C1)S(=O)(=O)CC(=O)C2=CC=C(C=C2)Cl	IC50 > 200000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	D02WUU	2-(phenylsulfonyl)-1-p-tolylethanone	Investigative	15627039	C15H14O3S	274.3	CC1=CC=C(C=C1)C(=O)CS(=O)(=O)C2=CC=CC=C2	IC50 > 200000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	D0EU9W	1-(3-methoxyphenyl)-2-(phenylsulfonyl)ethanone	Investigative	16750524	C15H14O4S	290.3	COC1=CC=CC(=C1)C(=O)CS(=O)(=O)C2=CC=CC=C2	IC50 > 200000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	D0M4PP	1-(4-methoxyphenyl)-2-(phenylsulfonyl)ethanone	Investigative	4271571	C15H14O4S	290.3	COC1=CC=C(C=C1)C(=O)CS(=O)(=O)C2=CC=CC=C2	IC50 > 200000 nM	Non binder
T43721	Corticosteroid 11-beta-dehydrogenase 2	D0P7RN	1-(4-fluorophenyl)-2-(phenylsulfonyl)ethanone	Investigative	1483401	C14H11FO3S	278.3	C1=CC=C(C=C1)S(=O)(=O)CC(=O)C2=CC=C(C=C2)F	IC50 > 200000 nM	Non binder