Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T04820 | Target Info | |||
| Target Name | Plasmodium CDK Pfmrk (Malaria Pfmrk) | ||||
| Synonyms |
Pfmrk; MO15-related protein kinase Pfmrk
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| Target Type | Patented-recorded Target | ||||
| Gene Name | Malaria Pfmrk | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 27 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chloroquine
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|
Approved | Compound Info | ||
| Synonyms |
Amokin; Aralen; Aralen HCl; Arechin; Arechine; Arequin; Arolen; Arthrochin; Artrichin; Avlochlor; Avloclor; Bemaco; Bemaphate; Bemasulph; Benaquin; Bipiquin; CU-01000012392-2; Capquin; Chemochin; Chingamin; Chloraquine; Chlorochin; Chlorochine; Chlorochinum; Chloroin; Chloroquin; Chloroquina; Chloroquine (USP/INN); Chloroquine (VAN); Chloroquine Bis-Phosphoric Acid; Chloroquine FNA (TN); Chloroquine [USAN:INN:BAN]; Chloroquine phosphate; Chloroquinium; Chloroquinum; Chloroquinum [INN-Latin]; Chlorquin; Cidanchin; Clorochina; Clorochina [DCIT]; Cloroquina; Cloroquina [INN-Spanish]; Cocartrit; Dawaquin (TN); Delagil; Dichinalex; Elestol; Gontochin; Gontochin phosphate; Heliopar; Imagon; Ipsen 225; Iroquine; Khingamin; Klorokin; Lapaquin; Malaquin; Malaquin (*Diphosphate*); Malaren; Malarex; Mesylith; Miniquine; Neochin; Nivachine; Nivaquine B; Pfizerquine; Quinachlor; Quinagamin; Quinagamine; Quinercyl; Quingamine; Quinilon; Quinoscan; RP 3377; RP-3377; Resochen; Resochin; Resochin (TN); Resoquina; Resoquine; Reumachlor; Reumaquin; Rivoquine; Ro 01-6014/N2; Ronaquine; Roquine; SN 6718; SN-7618; ST 21; ST 21 (pharmaceutical); Sanoquin; Silbesan;Siragan; Solprina; Sopaquin; Tanakan; Tanakene; Tresochin; Trochin; W 7618;WIN 244
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| Activity |
IC50 = 150000 nM
|
[1] | |||
| Compound Name |
Genistein
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Phase 2/3 | Compound Info | ||
| Synonyms |
Bonistein; GEN; Genestein; Genisteol; Genisterin; Prunetol; Sophoricol; Differenol A; G 6649; G10000; IN1327; NPI 031L; STO514; TNP00151; GENISTEIN (ENDOCRINE DISRUPTER); Lactoferrin-genistein; PTI G4660 (Genistein); PTI-G4660; SIPI 807-1; C.I. 75610; SIPI-9764-I; ENDOCRINE DISRUPTOR (GENISTEIN) (SEE ALSO GENISTEIN (446-72-0)); 4 inverted exclamation marka,5,7-Trihydroxyisoflavone; ,5,7-Trihydroxyisoflavone; 4',5, 7-Trihydroxyisoflavone; 4',5,7-Trihydroxy isoflavone; 4',5,7-Trihydroxyisoflavone; 4,5,7-Trihydroxyiso-flavone; 4,6,7-Trihydroxyisoflavone; 5,7,4'-Trihydroxyisoflavone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
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| Activity |
IC50 = 93000 nM
|
[1] | |||
| Compound Name |
9-Nitropaullone
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Investigative | Compound Info | ||
| Synonyms |
Alsterpaullone; alsterpaullone; 237430-03-4; NSC 705701; NSC-705701; CHEMBL50894; MLS002702475; 9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one; 9-nitro-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one; 9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one; 9-NITRO-5,12-DIHYDRO-7H-BENZO[2,3]AZEPINO[4,5-B]INDOL-6-ONE; Paullone Analog 1; AC1NMCUD; Kinome_3754; 1q3w; Alsterpaullone derivative, 2; Lopac0_000057; CBiol_001723; GTPL5925; BDBM7262; SCHEMBL2170104; CTK8F0374; ZINC23894; BDBM84528; DTXSID50407444
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| Activity |
IC50 = 51000 nM
|
[1] | |||
| Compound Name |
H-8
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Investigative | Compound Info | ||
| Synonyms |
84478-11-5; Protein kinase inhibitor H-8; h-8; H-8 Protein kinase inhibitor; N-(2-(Methylamino)ethyl)-5-isoquinolinesulfonamide; N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE; N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide; (5-Isoquinolylsulfonyl)[2-(methylamino)ethyl]amine; Lopac-M-9656; CHEMBL148333; CHEBI:43561; H8; N-(2-methylaminoethyl)isoquinoline-5-sulfonamide; (5-Isoquinolylsulfonyl)(2-(methylamino)ethyl)amine; 5-Isoquinolinesulfonamide, N-(2-(methylamino)ethyl)-; N-(2-(Methylamino)ethyl)isoquinoline- 5-s
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| Activity |
IC50 = 70000 nM
|
[2] | |||
| Compound Name |
Myricetin
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Investigative | Compound Info | ||
| Synonyms |
myricetin; 529-44-2; Cannabiscetin; Myricetol; Myricitin; 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one; 3,3',4',5,5',7-Hexahydroxyflavone; 3,5,7,3',4',5'-Hexahydroxyflavone; UNII-76XC01FTOJ; NSC 407290; CCRIS 5838; 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-; 3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one; 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one; EINECS 208-463-2; NSC407290; CHEMBL164; NSC-407290; BRN 0332331; 76XC01FTOJ
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| Activity |
IC50 = 157000 nM
|
[1] | |||
| Compound Name |
4-[3-Hydroxyanilino]-6,7-Dimethoxyquinazoline
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Investigative | Compound Info | ||
| Synonyms |
4-[3-Hydroxyanilino]-6,7-dimethoxyquinazoline; whi-p180; 211555-08-7; 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol; WHI-P180, Hydrochloride; JANEX 3; 4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE; CHEMBL127907; 3-((6,7-Dimethoxyquinazolin-4-yl)amino)phenol; AK341047; DTQ; 4-(3& -Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, HCl; JANEX-3; 4btk; 1di8; AC1L1KWT; AC1Q4XVE; 3-(6,7-dimethoxyquinazolin-4-ylamino)phenol; Anilinoquinazoline deriv 5; WHI-P180(Janex 3); BDBM4622; SCHEMBL1180103; CTK4E5981; AOB5495; MolPort-000-672-017; BNDYIYYKEIXHNK-UHFFFAOYSA-N; HMS3229P15; WHI-P180
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| Activity |
IC50 = 168000 nM
|
[3] | |||
| Compound Name |
3-(Naphthalen-1-yl)-1-(2,3,4-trimethoxyphenyl)prop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL218330; WR-289015; BDBM50193003
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
N,N''-(2,4,6-Trimethyl-1,3-phenylene)bis(4-bromobenzenesulfonamide)
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1172128; BDBM50321439
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| Activity |
IC50 = 50200 nM
|
[5] | |||
| Compound Name |
3-[(Methylamino)methylidene]-1,3-dihydro-2H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL127819; CTK2A6698; DTXSID30802791; BDBM50131996; 3-Methylaminomethylene-1,3-dihydro-indol-2-one; 2H-Indol-2-one, 1,3-dihydro-3-[(methylamino)methylene]-
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| Activity |
IC50 ~ 57000 nM
|
[3] | |||
| Compound Name |
Ethyl 2-(3-nitrobenzoyl)-3-(pyridin-2-yl)acrylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL471667; BDBM50278246; WR-203592
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| Activity |
IC50 = 61000 nM
|
[4] | |||
| Compound Name |
(Z)-2-(4-Nitro-benzoyl)-3-pyridin-2-yl-acrylic acid ethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL189865; BDBM50154599
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| Activity |
IC50 = 61000 nM
|
[1] | |||
| Compound Name |
N-(4-Chloro-2-methyl-phenyl)-3-nitro-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL187676; CBMicro_011451; Oprea1_113890; ZINC271652; SMSF0005573; BDBM50154594; AKOS002936215; CB14583; CCG-317673; MCULE-6073160581; BIM-0011237.P001; 4'-CHLORO-3-NITROBENZO-O-TOLUIDIDE; SR-01000206083; SR-01000206083-1
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| Activity |
IC50 = 69000 nM
|
[1] | |||
| Compound Name |
(3-Oxo-1-phenyl-1,3-dihydro-isobenzofuran-1-yl)-thiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL363972; BDBM50154601
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| Activity |
IC50 = 70000 nM
|
[1] | |||
| Compound Name |
Ethyl 2-chloro-5-nitrobenzoate
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Investigative | Compound Info | ||
| Synonyms |
2-chloro-5-nitrobenzoic acid ethyl ester; C9H8ClNO4; CHEMBL185627; Benzoic acid, 2-chloro-5-nitro-, ethyl ester; 2-Chloro-5-nitro-benzoic acid ethyl ester; Ethyl2-chloro-5-nitrobenzoate; SCHEMBL4420346; CTK4D2198; DTXSID70378945; ZINC152569; ethyl 2-chloranyl-5-nitro-benzoate; ANW-63900; BDBM50154610; MFCD00115803; SBB053767; STK401658; AKOS003235911; AS-9184; MCULE-5905517912; DB-015655; FT-0625949; ST50921858; Benzoic acid,2-chloro-5-nitro-, ethyl ester; A810678; J-520730
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| Activity |
IC50 = 87000 nM
|
[1] | |||
| Compound Name |
1-(4-Methoxyphenyl)-3-(1-naphthyl)prop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL221741; WR-289017; NSC201639; SCHEMBL16210890; 1-(4-methoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one; ZINC4277220; 4-[3-(1-Naphthyl)acryloyl]anisole; BDBM50193022; MFCD00117865; NSC-201639; AB00083711-01; (E)-1-(4-methoxyphenyl)-3-(1-naphthyl)prop-2-en-1-one; (E)-1-(4-methoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one; (2E)-1-(4-Methoxyphenyl)-3-(naphthalen-1-yl)prop-2-en-1-one
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-(3-(4-Chlorophenyl)acryloyl)benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL468255; WR-266320; BDBM50278247; AKOS000954362
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-(2,4-Dimethoxyphenyl)-3-(naphthalen-2-yl)prop-2-en-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL221432; WR-289011; BDBM50193028; 1-(2',4'-Dimethoxyphenyl)-3-(2-napthyl)-2-propen-1-one; (E)-1-(2,4-dimethoxyphenyl)-3-(2-naphthyl)prop-2-en-1-one
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| Activity |
IC50 = 100000 nM
|
[4] | |||
| Compound Name |
3-(2-Oxo-1,2-dihydroquinoline-3-yl)phenoxyacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL97264; BDBM50105768; [3-(2-Oxo-1,2-dihydro-quinolin-3-yl)-phenoxy]-acetic acid
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| Activity |
IC50 = 102000 nM
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[6] | |||
| Compound Name |
5-Bromo-3-(2-oxo-2-p-tolyl-ethylidene)-1,3-dihydro-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL126408; BDBM50131998
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| Activity |
IC50 = 120000 nM
|
[3] | |||
| Compound Name |
5-Bromo-3-(2-oxo-2-phenylethylidene)-1,3-dihydroindol-2-one
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Investigative | Compound Info | ||
| Synonyms |
MLS002702136; CHEMBL363491; NSC294961; 5-bromo-3-(2-oxo-2-phenylethylidene)indolin-2-one; cid_5477132; 3-Phenacyliden-5-brom-2-indolinon; BDBM50154618; CCG-35540; ZINC18101382; AKOS024363377; NSC-294961; SMR001565701; ST50994796; 2H-Indol-2-one,3-dihydro-3-(2-oxo-2-phenylethylidene)-; 5-bromo-3-(2-oxo-2-phenylethylidene)-1H-benzo[d]azolin-2-one; 5-Bromo-3-(2-oxo-2-phenyl-ethylidene)-1,3-dihydro-indol-2-one; 5-Bromo-3-(2-oxo-2-phenylethylidene)- 1,3-dihydroindol-2-one
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| Activity |
IC50 = 120000 nM
|
[3] | |||
| Compound Name |
2,2-Dichloro-N-(2,5-dichlorothiophen-3-ylsulfonyl)-N-p-tolylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1172361; BDBM50321458
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| Activity |
IC50 = 127200 nM
|
[5] | |||
| Compound Name |
(3Z)-3-[2-(4-Bromophenyl)-2-oxoethylidene]-1,3-dihydro-2H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1213804; ZINC547375; BDBM50409725; EiM08-08951; STK094110; AKOS005395401; 3-(4-Bromophenacylidene)indoline-2-one
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| Activity |
IC50 = 130000 nM
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[3] | |||
| Compound Name |
1H-Indole-2(3H)-one, 3-(4-trifluoromethylbenzylidene)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL337993; HMS550A18; BDBM50132002; ZINC12340046; AKOS001451147; CCG-274062; 3-(4-(trifluoromethyl)benzylidene)indolin-2-one; (E)-3-(4-(Trifluoromethyl)benzylidene)indolin-2-one; 3-(4-Trifluoromethyl-benzylidene)-1,3-dihydro-indol-2-one; (3E)-3-[4-(Trifluoromethyl)benzylidene]-1,3-dihydro-2H-indol-2-one #
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| Activity |
IC50 = 138000 nM
|
[1] | |||
| Compound Name |
3-[(E)-beta-Oxophenethylidene]indoline-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL126602; 3-(2-Oxo-2-phenyl-ethylidene)-1,3-dihydro-indol-2-one; MLS001173238; cid_682361; HMS2873G21; BDBM50131991; ZINC31719993; AKOS030513875; SMR000539029
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| Activity |
IC50 = 150000 nM
|
[3] | |||
| Compound Name |
2-Hydrazino-3-(1H-indol-3-yl)-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185794; SCHEMBL680575; BDBM50154602; 2-hydrazinyl-3-(1H-indol-3-yl)propanoic acid
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| Activity |
IC50 = 182000 nM
|
[1] | |||
| Compound Name |
7-Hydroxy-10H-11-oxa-10-aza-benzo[b]fluoren-5-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL318416; BDBM50105766; 9-Hydroxy-6,11-dihydrobenzofuro[2,3-b]quinoline-11-one
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| Activity |
IC50 = 187000 nM
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[6] | |||
| Compound Name |
(3E)-5-Bromo-3-[2-(4-fluorophenyl)-2-oxoethylidene]-1H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL127798; 5-bromo-3-[2-(4-fluorophenyl)-2-oxo-ethylidene]-1,3-dihydroindol-2-one; BDBM50131992; ZINC36124475; 5-Bromo-3-(2-(4-fluorophenyl)-2-oxoethylidene)indolin-2-one; 5-Bromo-3-[2-(4-fluoro-phenyl)-2-oxo-ethylidene]-1,3-dihydro-indol-2-one
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| Activity |
IC50 = 190000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 16 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Fasudil
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Phase 3 | Compound Info | ||
| Synonyms |
103745-39-7; HA1077; ha-1077; HA 1077; Fasudil [INN]; AT 877; Fasudilum [INN-Latin]; 1-(5-Isoquinolinesulfonyl)homopiperazine; 1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-; UNII-Q0CH43PGXS; 5-(1,4-diazepane-1-sulfonyl)isoquinoline; 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline; (5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE; AT-877; AT877; Q0CH43PGXS; 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE; CHEMBL38380; Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine; Fasudil (INN); Fasudilhydrochloride
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| Activity |
IC50 > 500000 nM
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[2] | |||
| Compound Name |
R-roscovitine
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Phase 2 | Compound Info | ||
| Synonyms |
Seliciclib; roscovitine; 186692-46-6; R-Roscovitine; (R)-roscovitine; CYC202; CYC-202; CYC 202; 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine; UNII-0ES1C2KQ94; Roscovitine (Seliciclib,CYC202); NSC 701554; AL-39256; Roscovitine; CHEMBL14762; 0ES1C2KQ94; CHEBI:45307; NSC701554; NSC-701554; (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol; (R)-2-((6-(Benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol; (2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol; RRC; Rosco; M02443; BMK1-E12; CYC202, Seliciclib, R-roscovitine, Roscovitine; (2r)-2-{[6-(benzylamino)-9-isopropyl-9h-purin-2-yl]amino}-1-butanol; 2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol; 2-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-(R)-1-butanol; 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine
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| Activity |
IC50 > 1000000 nM
|
[3] | |||
| Compound Name |
Olomoucine
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Terminated | Compound Info | ||
| Synonyms |
olomoucine; 101622-51-9; 4erk; UNII-6A839B2HYS; 2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine; 6A839B2HYS; CHEMBL280074; 2-{[6-(benzylamino)-9-methyl-9h-purin-2-yl]amino}ethanol; 6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine; 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine; Ethanol,2-[[9-methyl-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-; OLO; 2-(Hydroxyethylamino)-6-benzylamino-9-methylpurine; 6-Benylamino-2-(2-hydroxyethylamino)-9-methylpurine
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| Activity |
IC50 > 1000000 nM
|
[3] | |||
| Compound Name |
ML9
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Investigative | Compound Info | ||
| Synonyms |
ML-9 free base; UNII-LTJ3F5128V; 110448-31-2; LTJ3F5128V; CHEMBL429298; ML9; 1-[(5-chloro-1-naphthyl)sulfonyl]-1,4-diazepane; 1H-1,4-Diazepine, 1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-; Tocris-0431; ACMC-20mde5; BiomolKI_000043; AC1L1HOD; Lopac-C-1172; BiomolKI2_000008; Lopac0_000209; BSPBio_001271; GTPL4256; SCHEMBL2869228; CTK0D4761; CHEBI:93202; DTXSID00149246; ZINC402771; HMS1792O13; Bio1_000938; Bio1_001427; Bio1_000449; HMS3403O13; HMS1990O13; BDBM50216681; 1H-1,4-Diazepine, 1-((5-chloro-1-naphthalenyl)sulfonyl)hexahydro-)
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| Activity |
IC50 > 500000 nM
|
[2] | |||
| Compound Name |
H-89
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Investigative | Compound Info | ||
| Synonyms |
H 89
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| Activity |
IC50 > 500000 nM
|
[2] | |||
| Compound Name |
(2E)-1,3-Bis(3-nitrophenyl)-2-buten-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL471254; WR-118117; NSC35988; ZINC5411754; BDBM50278197; NSC-35988; NSC407268; NSC-407268; 1,3-bis(3-nitrophenyl)but-2-en-1-one
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| Activity |
IC50 > 256000 nM
|
[4] | |||
| Compound Name |
3',4-Dinitrochalcone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL471253; WR-226212; Chalcone, 3',4-dinitro-; 3',4-Dinitrocalcone; 3',4-Dinitrocalcone [Italian]; 1-(3-nitrophenyl)-3-(4-nitrophenyl)prop-2-en-1-one; BDBM50278196; ZINC16406610; AKOS000953900; 1-[3-Nitrophenyl]-3-[4-nitrophenyl]-2-propen-1-one; (2E)-1-(3-Nitrophenyl)-3-(4-nitrophenyl)-2-propen-1-one #
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| Activity |
IC50 = 268000 nM
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[4] | |||
| Compound Name |
2,5-Dichloro-N-(3,5-dichlorophenyl)thiophene-3-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1172132; BDBM50321453
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| Activity |
IC50 = 332800 nM
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[5] | |||
| Compound Name |
N-(4-Aminobutyl)naphthalene-1-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL251113; SCHEMBL8024067; BDBM50216678; n-(4-aminobutyl)-1-naphthalenesulfonamide; N-(4-aminobutyl)-1-naphthalenesulphonamide
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| Activity |
IC50 > 500000 nM
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[2] | |||
| Compound Name |
1H-1,4-Diazepine, hexahydro-1-((5-iodo-1-naphthalenyl)sulfonyl)-
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Investigative | Compound Info | ||
| Synonyms |
UNII-E2C2LB77BF; 1-((5-iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane; E2C2LB77BF; CHEMBL249089; 1-[(5-iodo-1-naphthyl)sulfonyl]-1,4-diazepane; 1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hcl; BiomolKI_000042; 1H-1,4-Diazepine, hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-; 1-(5-iodonaphthalen-1-yl)sulfonyl-1,4-diazepane; ACMC-20d0mo; Lopac-I-2764; BiomolKI2_000007; CBiol_002005; Lopac0_000641; BSPBio_001269; KBioGR_000609; KBioSS_000609; SCHEMBL1271163; BCBcMAP01_000168; CTK4A6888; KBio2_000609; KBio2_003177; KBio2_005745; KBio3_001077; KBio3_001078; DTXSID60148917; Bio1_000291; Bio1_000780; Bio1_001269; Bio2_000465; Bio2_000945; HMS1362O11; HMS1792O11; HMS1990O11; HMS3403O11; HMS3674C17; BCP18323; ZINC2597113; BDBM50216683; EI-197; CCG-100646; SDCCGSBI-0050621.P003; IDI1_002220; SMP1_000196; NCGC00015554-01; NCGC00015554-02; NCGC00015554-03; NCGC00015554-04; NCGC00015554-05; NCGC00015554-06; NCGC00015554-14; NCGC00162209-01; NCGC00162209-02; NCGC00162209-03; NCGC00162209-04; DB-083045; FT-0765001; 1-(5-iodonaphthalen-1-ylsulfonyl)-1,4-diazepane; BRD-K93201660-001-04-0; Q27147942; 1-[(5-iodo-1-naphthyl)sulfonyl]hexahydro-1H-1,4-diazepine
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| Activity |
IC50 > 500000 nM
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[2] | |||
| Compound Name |
N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
1-NAPHTHALENESULFONAMIDE, N-(6-AMINOHEXYL)-5-CHLORO-; N-(6-aminohexyl)-5-chloronaphthalene-1-sulfonamide; CHEMBL41631; N-AMINOHEXYL-5-CHLORO-1-NAPTHALENESULFONAMIDE HYDROCHLORIDE; N-(6-Aminohexyl)-5-chloro-1-naphthalenesulphonamide; Spectrum_000286; BRN 2888957; Spectrum_001450; Tocris-0369; Spectrum2_001569; Spectrum3_001600; Spectrum4_000316; Spectrum5_001878; Lopac-A-3281; Lopac0_000075; BSPBio_001230; BSPBio_003200; KBioGR_000932; KBioSS_000766; KBioSS_001930; DivK1c_000102; DivK1c_000129; DivK1c_001015; SCHEMBL166960; SPBio_001478; HMS500F04; KBio1_000102; KBio1_000129; KBio1_001015; KBio2_000766; KBio2_001930; KBio2_003334; KBio2_004498; KBio2_005902; KBio2_007066; KBio3_002700; DTXSID80984172; NINDS_000102; NINDS_000129; NINDS_001015; Bio1_000399; Bio1_000888; Bio1_001377; KUC109782N; ZINC1649496; BDBM50111446; CA-320; CCG-204170; DB04513; IDI1_000102; IDI1_000129; IDI1_001015; KSC-210-030; NCGC00015050-01; NCGC00015050-02; NCGC00015050-03; NCGC00015050-04; NCGC00015050-05; NCGC00024557-01; NCGC00024557-02; NCGC00024557-03; N-(6-Aminohexyl)-1-chloronaphthalene-5-sulfonamide; N-AMINOHEXYL-5-CHLORONAPHTH-1-YLSULFONAMIDE; Q2536561; BRD-K90259198-003-02-2; BRD-K90259198-003-04-8; [6-[[(5-Chloronaphthalen-1-yl)sulfonyl]amino]hexyl]amine; 5-Chloro-naphthalene-1-sulfonic acid (6-amino-hexyl)-amide
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| Activity |
IC50 > 500000 nM
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[2] | |||
| Compound Name |
N-(4-Aminobutyl)-5-chloronaphthalene-1-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL250517; NCGC00015031-01; Lopac-A-0666; Lopac0_000013; SCHEMBL1929636; CTK2I6532; DTXSID50274476; ZINC2169538; BDBM50216684; CCG-204109; N-(4-aminobutyl)-5-chloro-1-naphthalenesulphonamide; 1-Naphthalenesulfonamide, N-(4-aminobutyl)-5-chloro-; N-(4-AMINOBUTYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE
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| Activity |
IC50 > 500000 nM
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[2] | |||
| Compound Name |
5-{[(2S)-2-Methylpiperazin-1-yl]sulfonyl}isoquinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1233654; SCHEMBL13186235; BDBM50366348; ZINC34800307; AKOS021010761; Q27097224; UNII-487H9Q0F9N component BDVFVCGFMNCYPV-NSHDSACASA-N
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| Activity |
IC50 > 500000 nM
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[2] | |||
| Compound Name |
N-(2-Guanidinoethyl)-5-isoquinolinesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
ha-1004; CHEMBL143054; H-1004; HA1004; N-(2-guanidinoethyl)isoquinoline-5-sulfonamide; 2-[2-(5-isoquinolinylsulfonylamino)ethyl]guanidine; Amino{2-[(5-isoquinolylsulfonyl)amino]ethyl}carboxamidine; HA 1004; HT 1004; KBioGR_000453; n-(2-carbamimidamidoethyl)isoquinoline-5-sulfonamide; N-(2-((Aminoiminomethyl)amino)ethyl)-5-isoquinolinesulfonamide; BiomolKI_000037; BiomolKI2_000045; BSPBio_001113; KBioSS_000453; 2-[2-(isoquinolin-5-ylsulfonylamino)ethyl]guanidine; SCHEMBL1272417; KBio2_000453; KBio2_003021; KBio2_005589; KBio3_000845; KBio3_000846; BRD4375; DTXSID60919543; Bio2_000387; Bio2_000867; HMS1362G15; HMS1792G15; HMS1990G15; HMS3403G15; BRD-4375; ZINC2170223; BDBM50216680; AKOS024285644; CCG-100641; IDI1_002142; NCGC00163379-01; NCGC00163379-02; NCGC00163379-03; ST086170; 1-(2-(isoquinoline-5-sulfonamido)ethyl)guanidine; 1-[2-(5-isoquinolylsulfonylamino)ethyl]guanidine; BRD-K05434375-001-03-2; BRD-K05434375-001-04-0; Q27163889
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| Activity |
IC50 > 500000 nM
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[2] | |||
| Compound Name |
1-(5-Isoquinolinesulfonyl)piperazine
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Investigative | Compound Info | ||
| Synonyms |
5-(piperazin-1-ylsulfonyl)isoquinoline; 5-piperazin-1-ylsulfonylisoquinoline; ha-100; 5-(1-Piperazinylsulfonyl)isoquinoline; CHEMBL75773; Isoquinoline,5-(1-piperazinylsulfonyl)-; HA 100 (pharmaceutical); 1-(5-Isoquinolinylsulfonyl)piperazine; Tocris-0543; Piperazine, 1-(5-isoquinolinylsulfonyl)-; isoquinoline-5-sulfonamide 18; HA-100 2HCl; SCHEMBL1272907; BDBM15203; CTK5F2377; BRD2751; DTXSID60233438; HA100; HMS3266K06; HMS3411C20; HMS3675C20; BRD-2751; HA 100; MFCD00209852; ZINC35024805; 1-(5-isoquinolinesulfonyl) piperazine; 5-(piperazine-1-sulfonyl)isoquinoline; AKOS009604745; 1-(5-Isoquinolinylsulfonyl)-piperazine; NCGC00024641-01; HY-100984; B6343; CS-0020664; Isoquinoline-5-sulfonic acid piperazin-1 ylamide; SR-01000597700; SR-01000597700-1; BRD-K72462751-001-01-9; Q27164985
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| Activity |
IC50 > 500000 nM
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[2] | |||
| Compound Name |
2-Hydroxy-5,6-dihydrobenzofuro[3,2-c]quinoline-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL95917; BDBM50105770; 2-Hydroxy-5H-11-oxa-5-aza-benzo[a]fluoren-6-one
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| Activity |
IC50 = 539000 nM
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[6] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different class... J Med Chem. 2004 Oct 21;47(22):5418-26. | ||||
| REF 2 | Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4961-6. | ||||
| REF 3 | Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases. J Med Chem. 2003 Aug 28;46(18):3877-82. | ||||
| REF 4 | Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. | ||||
| REF 5 | Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases. Bioorg Med Chem Lett. 2010 Jul 1;20(13):3863-7. | ||||
| REF 6 | Design and synthesis of Pfmrk inhibitors as potential antimalarial agents. Bioorg Med Chem Lett. 2001 Nov 5;11(21):2875-8. | ||||
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