Drug Information
| Drug General Information | Top | |||
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| Drug ID |
D02NGU
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| Former ID |
DIB019992
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| Drug Name |
H-8
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| Synonyms |
84478-11-5; Protein kinase inhibitor H-8; h-8; H-8 Protein kinase inhibitor; N-(2-(Methylamino)ethyl)-5-isoquinolinesulfonamide; N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE; N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide; (5-Isoquinolylsulfonyl)[2-(methylamino)ethyl]amine; Lopac-M-9656; CHEMBL148333; CHEBI:43561; H8; N-(2-methylaminoethyl)isoquinoline-5-sulfonamide; (5-Isoquinolylsulfonyl)(2-(methylamino)ethyl)amine; 5-Isoquinolinesulfonamide, N-(2-(methylamino)ethyl)-; N-(2-(Methylamino)ethyl)isoquinoline- 5-s
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
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Download2D MOL
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| Formula |
C12H15N3O2S
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| Canonical SMILES |
CNCCNS(=O)(=O)C1=CC=CC2=C1C=CN=C2
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| InChI |
1S/C12H15N3O2S/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12/h2-6,9,13,15H,7-8H2,1H3
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| InChIKey |
PJWUXKNZVMEPPH-UHFFFAOYSA-N
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| CAS Number |
CAS 84478-11-5
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| PubChem Compound ID | ||||
| PubChem Substance ID |
645245, 841195, 7404189, 7888465, 7979490, 8152241, 11111503, 15417315, 26713166, 26755703, 29222671, 46393648, 46515520, 46530868, 47662087, 47736271, 48110267, 48184807, 50065300, 50111160, 57321862, 78388204, 85787245, 90341431, 99444468, 103072844, 103083245, 103389922, 104303812, 117630382, 118696517, 124658735, 124880800, 124880801, 126407649, 128926731, 134223625, 135061936, 135650343, 137245022, 141537158, 142783307, 143858039, 144107756, 145470216, 160969054, 162920721, 164758652, 164810761, 179148592
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| ChEBI ID |
CHEBI:43561
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cyclic nucleotide-gated channel alpha-1 (CNGA1) | Target Info | Blocker (channel blocker) | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2348). | |||
| REF 2 | Direct blockade of both cloned rat rod photoreceptor cyclic nucleotide-gated non-selective cation (CNG) channel alpha-subunit and native CNG channels from Xenopus rod outer segments by H-8, a non-specific cyclic nucleotide-dependent protein kinase inhibitor. Neurosci Lett. 1997 Sep 12;233(1):37-40. | |||
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