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Protein General Information |
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Full Name |
Ski oncogene (SKI)
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UniProt ID |
SKI_HUMAN
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Gene Name |
SKI
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Gene ID |
6497
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Interacting TTD Target Information |
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Interacting Clinical trial Target(s) |
Retinoic acid receptor alpha (RARA) |
Target Info
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PPI Info
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[1] |
Interacting Preclinical Target(s) |
Mothers against decapentaplegic homolog 3 (SMAD3) |
Target Info
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PPI Info
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[2] |
References |
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REF 1 |
The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signaling pathway. Biochem Biophys Res Commun. 2009 May 22;383(1):119-24.
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REF 2 |
Direct interaction of Ski with either Smad3 or Smad4 is necessary and sufficient for Ski-mediated repression of transforming growth factor-beta signaling. J Biol Chem. 2003 Aug 29;278(35):32489-92.
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