Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T94085 Target Info
Target Name Retinoic acid receptor alpha (RARA)
Synonyms RAR-alpha; RAR alpha; Nuclear receptor subfamily 1 group B member 1; NR1B1
Target Type Clinical trial Target
Gene Name RARA
Biochemical Class Nuclear hormone receptor
UniProt ID
RARA_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Proteasome 26S subunit ATPase 5 (PSMC5) Interacting Protein Interacting Protein Info
UniProt ID
PRS8_HUMAN 
Synonyms S8; SUG.1; SUG1; TBP10; TRIP1; p45; p45/SUG
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [3]
4 Yeast two hybrid [4]
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 6 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [5]
2 Reconstituted Complex [6]
3 Reconstituted Complex [7]
4 Reconstituted Complex [5]
5 Reconstituted Complex [8]
6 Yeast two hybrid [9]
Interacting Target Name Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA3_HUMAN 
Synonyms TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [10]
3 Reconstituted Complex [6]
4 Reconstituted Complex [11]
5 Yeast two hybrid [12]
Mediator complexes [+] 1 Mediator complexes +
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 1 (MED1) Interacting Protein Interacting Protein Info
UniProt ID
MED1_HUMAN 
Synonyms CRSP1; CRSP200; DRIP205; DRIP230; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Co-crystal Structure [13]
3 Fluorescence Resonance Energy Transfer [5]
4 Reconstituted Complex [5]
5 Yeast two hybrid [14]
Nuclear hormone receptors [+] 5 Nuclear hormone receptors +
Interacting Target Name Retinoic acid receptor RXR-alpha (RXRA) Successful Target Interacting Protein Info
UniProt ID
RXRA_HUMAN 
Synonyms RXRalpha; Retinoid X receptor alpha; Nuclear receptor subfamily 2 group B member 1; NR2B1
Evidence Score (E-score) 14 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Affinity Capture-Western [16]
3 Co-crystal Structure [17]
4 Co-localization [18]
5 Co-purification [19]
6 Far Western [20]
7 Reconstituted Complex [21]
8 Reconstituted Complex [8]
9 Reconstituted Complex [13]
10 Reconstituted Complex [22]
11 Yeast two hybrid [23]
12 Yeast two hybrid [24]
13 Yeast two hybrid [25]
14 Yeast two hybrid [22]
Interacting Target Name Retinoic acid receptor RXR-gamma (RXRG) Successful Target Interacting Protein Info
UniProt ID
RXRG_HUMAN 
Synonyms Retinoid X receptor gamma; Nuclear receptor subfamily 2 group B member 3; NR2B3
Evidence Score (E-score) 5 Experimental Evidences +
1 Yeast two hybrid [26]
2 Yeast two hybrid [27]
3 Yeast two hybrid [24]
4 Yeast two hybrid [25]
5 Yeast two hybrid [28]
Interacting Target Name Retinoic acid receptor RXR-beta (RXRB) Successful Target Interacting Protein Info
UniProt ID
RXRB_HUMAN 
Synonyms Retinoid X receptor beta; Nuclear receptor subfamily 2 group B member 2; NR2B2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [29]
2 Yeast two hybrid [28]
3 Yeast two hybrid [24]
4 Yeast two hybrid [25]
Interacting Target Name Retinoic acid receptor beta (RARB) Successful Target Interacting Protein Info
UniProt ID
RARB_HUMAN 
Synonyms RAR-epsilon; RAR-beta; Nuclear receptor subfamily 1 group B member 2; NR1B2; HBV-activated protein; HAP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [29]
2 Co-localization [30]
Interacting Target Name Orphan nuclear receptor SHP (NR0B2) Literature-reported Target Interacting Protein Info
UniProt ID
NR0B2_HUMAN 
Synonyms Small heterodimer partner; SHP; Short heterodimer partner; Nuclear receptor subfamily 0 group B member 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [31]
2 Yeast two hybrid [32]
Transcription regulators [+] 7 Transcription regulators +
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [33]
2 Affinity Capture-Western [34]
3 Far Western [8]
4 Reconstituted Complex [35]
5 Reconstituted Complex [8]
6 Reconstituted Complex [36]
7 Reconstituted Complex [37]
8 Yeast two hybrid [35]
9 Yeast two hybrid [38]
Interacting Protein Name Krueppel-like factor 5 (KLF5) Interacting Protein Interacting Protein Info
UniProt ID
KLF5_HUMAN 
Synonyms BTEB2; CKLF; IKLF
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [39]
2 Affinity Capture-Western [16]
3 Affinity Capture-Western [40]
4 Reconstituted Complex [39]
Interacting Protein Name Nuclear receptor coactivator 2 (NCOA2) Interacting Protein Interacting Protein Info
UniProt ID
NCOA2_HUMAN 
Synonyms GRIP1; KAT13C; NCoA.2; SRC2; TIF2; bHLHe75
Evidence Score (E-score) 4 Experimental Evidences +
1 Reconstituted Complex [2]
2 Reconstituted Complex [6]
3 Reconstituted Complex [41]
4 Yeast two hybrid [42]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [43]
2 Co-localization [44]
3 Reconstituted Complex [45]
Interacting Protein Name Nuclear receptor corepressor 2 (NCOR2) Interacting Protein Interacting Protein Info
UniProt ID
NCOR2_HUMAN 
Synonyms CTG26; N.CoR2; SMAP270; SMRT; SMRTE; SMRTE.tau; TNRC14; TRAC; TRAC.1; TRAC1
Evidence Score (E-score) 3 Experimental Evidences +
1 Far Western [20]
2 Reconstituted Complex [46]
3 Reconstituted Complex [47]
Interacting Protein Name Ski oncogene (SKI) Interacting Protein Interacting Protein Info
UniProt ID
SKI_HUMAN 
Synonyms SGS; SKV
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [48]
2 Affinity Capture-Western [49]
3 Co-localization [49]
Interacting Protein Name Transcriptional adapter 3 (TADA3) Interacting Protein Interacting Protein Info
UniProt ID
TADA3_HUMAN 
Synonyms ADA3; NGG1; STAF54; TADA3L; hADA3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [50]
2 Yeast two hybrid [12]
Other proteins [+] 2 Other proteins +
Interacting Protein Name Nuclear receptor-interacting protein 1 (NRIP1) Interacting Protein Interacting Protein Info
UniProt ID
NRIP1_HUMAN 
Synonyms RIP140
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [51]
2 Reconstituted Complex [52]
3 Reconstituted Complex [2]
4 Yeast two hybrid [27]
Interacting Protein Name Promyelocytic leukemia protein (PML) Interacting Protein Interacting Protein Info
UniProt ID
PML_HUMAN 
Synonyms MYL; PP8675; RNF71; TRIM19
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [53]
2 Reconstituted Complex [54]
References  Top
REF 1 SUG-1 plays proteolytic and non-proteolytic roles in the control of retinoic acid target genes via its interaction with SRC-3. J Biol Chem. 2009 Mar 20;284(12):8127-35.
REF 2 Synthetic retinoids dissociate coactivator binding from corepressor release. J Recept Signal Transduct Res. 2002 Feb-Nov;22(1-4):31-61.
REF 3 Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J. 1996 Jan 2;15(1):110-24.
REF 4 A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily. J Steroid Biochem Mol Biol. 1996 Jan;56(1-6 Spec No):23-30.
REF 5 Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4363-8.
REF 6 The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature. 1997 Jun 12;387(6634):677-84.
REF 7 Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation. Mol Cell Biol. 1999 Sep;19(9):6323-32.
REF 8 Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors. Mol Cell Biol. 1997 Apr;17(4):2166-76.
REF 9 A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors. Nucleic Acids Res. 2013 Nov;41(21):9663-79.
REF 10 P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription. EMBO J. 2006 Feb 22;25(4):739-51.
REF 11 TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. J Biol Chem. 1997 Oct 31;272(44):27629-34.
REF 12 Human ADA3 regulates RARalpha transcriptional activity through direct contact between LxxLL motifs and the receptor coactivator pocket. Nucleic Acids Res. 2010 Sep;38(16):5291-303.
REF 13 Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings. Nat Struct Mol Biol. 2011 May;18(5):564-70.
REF 14 MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. EMBO J. 2007 Aug 8;26(15):3545-57.
REF 15 Ubiquitinated or sumoylated retinoic acid receptor alpha determines its characteristic and interacting model with retinoid X receptor alpha in gastric and breast cancer cells. J Mol Endocrinol. 2004 Jun;32(3):595-613.
REF 16 Synthetic retinoid Am80 suppresses smooth muscle phenotypic modulation and in-stent neointima formation by inhibiting KLF5. Circ Res. 2005 Nov 25;97(11):1132-41.
REF 17 Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators thro... J Biol Chem. 2005 Jan 14;280(2):1625-33.
REF 18 Cytoplasmic function of mutant promyelocytic leukemia (PML) and PML-retinoic acid receptor-alpha. J Biol Chem. 2006 May 19;281(20):14465-73.
REF 19 RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors. EMBO J. 1992 Apr;11(4):1409-18.
REF 20 Characterization of receptor interaction and transcriptional repression by the corepressor SMRT. Mol Endocrinol. 1997 Dec;11(13):2025-37.
REF 21 Identification of a thyroid hormone response element in the promoter region of the rat lipocalin-type prostaglandin D synthase (beta-trace) gene. Brain Res Mol Brain Res. 1998 Apr;55(2):321-30.
REF 22 PLZF is a negative regulator of retinoic acid receptor transcriptional activity. Nucl Recept. 2003 Sep 6;1(1):6.
REF 23 A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1. Genes Dev. 1995 Apr 1;9(7):769-82.
REF 24 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 25 Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13.
REF 26 Next-generation sequencing to generate interactome datasets. Nat Methods. 2011 Jun;8(6):478-80.
REF 27 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 28 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.
REF 29 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 30 Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma. PLoS One. 2011;6(10):e26236.
REF 31 An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science. 1996 May 31;272(5266):1336-9.
REF 32 Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner). Mol Endocrinol. 1998 Oct;12(10):1551-7.
REF 33 Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature. 1998 Feb 19;391(6669):815-8.
REF 34 Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell. 2006 Feb 10;124(3):615-29.
REF 35 Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein. J Biol Chem. 1999 May 28;274(22):15901-7.
REF 36 Functional analyses of an LXXLL motif in nuclear receptor corepressor (N-CoR). J Steroid Biochem Mol Biol. 2004 Aug;91(4-5):191-6.
REF 37 Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature. 1995 Oct 5;377(6548):397-404.
REF 38 Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol Syst Biol. 2016 Apr 22;12(4):863.
REF 39 Acyclic retinoid inhibits functional interaction of transcription factors Krpel-like factor 5 and retinoic acid receptor-alpha. FEBS Lett. 2008 May 28;582(12):1755-60.
REF 40 Significance of the transcription factor KLF5 in cardiovascular remodeling. J Thromb Haemost. 2005 Aug;3(8):1569-76. Review
REF 41 The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J. 1998 Jan 15;17(2):507-19.
REF 42 Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs. Mol Cell Biol. 2003 Mar;23(6):2135-50.
REF 43 Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism. J Clin Endocrinol Metab. 2008 May;93(5):1915-23.
REF 44 Retinoic acid activates monoamine oxidase B promoter in human neuronal cells. J Biol Chem. 2009 Jun 19;284(25):16723-35.
REF 45 Physical interaction between retinoic acid receptor and Sp1: mechanism for induction of urokinase by retinoic acid. Blood. 1999 Jun 15;93(12):4264-76.
REF 46 Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10762-7.
REF 47 Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). Mol Pharmacol. 2006 Jan;69(1):99-108.
REF 48 The Ski protein can inhibit ligand induced RARalpha and HDAC3 degradation in the retinoic acid signaling pathway. Biochem Biophys Res Commun. 2009 May 22;383(1):119-24.
REF 49 Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemia. Leukemia. 2006 Mar;20(3):437-43.
REF 50 Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator. J Biol Chem. 2002 Nov 22;277(47):45611-8.
REF 51 Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation. J Biol Chem. 2004 Jan 2;279(1):319-25.
REF 52 RIP-140 interacts with multiple nuclear receptors by means of two distinct sites. Mol Cell Biol. 1996 Nov;16(11):6029-36.
REF 53 PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia. Cancer Cell. 2010 Feb 17;17(2):186-97.
REF 54 A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nat Genet. 1999 Nov;23(3):287-95.

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