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Protein General Information (TTD Target) |
Top |
Full Name |
Cyclin-dependent kinase 8 (CDK8)
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Clinical trial
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Target Info
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UniProt ID |
CDK8_HUMAN
|
Gene Name |
CDK8
|
Gene ID |
1024
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Interacting TTD Target Information |
Top |
Interacting Successful Target(s) |
Poly [ADP-ribose] polymerase 1 (PARP1) |
Target Info
|
PPI Info
|
[1] |
Interacting Clinical trial Target(s) |
Cyclin-dependent kinase 8 (CDK8) |
Target Info
|
PPI Info
|
[2] |
Interacting Literature-reported Target(s) |
Sterol regulatory element binding protein-1 (SREBF1) |
Target Info
|
PPI Info
|
[3] |
References |
Top |
REF 1 |
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell. 2005 Apr 1;18(1):83-96.
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REF 2 |
The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. Genes Dev. 2013 Jan 15;27(2):151-6.
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REF 3 |
Structure, function, and activator-induced conformations of the CRSP coactivator. Science. 2002 Feb 8;295(5557):1058-62.
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