Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T47236 Target Info
Target Name Sterol regulatory element binding protein-1 (SREBF1)
Synonyms bHLHd1; Sterol regulatory element-binding transcription factor 1; Sterol regulatory element-binding protein 1; SREBP1; SREBP-1; SREBP 1; Class D basic helix-loop-helix protein 1
Target Type Literature-reported Target
Gene Name SREBF1
UniProt ID
SRBP1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Co-purification [3]
4 Reconstituted Complex [1]
5 Reconstituted Complex [3]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name NAD-dependent deacetylase sirtuin-1 (SIRT1) Clinical trial Target Interacting Protein Info
UniProt ID
SIR1_HUMAN 
Synonyms SIR2-like protein 1; SIR2L1; Regulatory protein SIR2 homolog 1; NAD-dependent protein deacetylase sirtuin-1; hSIRT1; hSIR2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Biochemical Activity [5]
3 Reconstituted Complex [4]
Kinases [+] 1 Kinases +
Interacting Target Name Cyclin-dependent kinase 8 (CDK8) Clinical trial Target Interacting Protein Info
UniProt ID
CDK8_HUMAN 
Synonyms Protein kinase K35; Mediator of RNA polymerase II transcription subunit CDK8; Mediator complex subunit CDK8; Cell division protein kinase 8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Reconstituted Complex [7]
Mediator complexes [+] 12 Mediator complexes +
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 15 (MED15) Interacting Protein Interacting Protein Info
UniProt ID
MED15_HUMAN 
Synonyms ARC105; CAG7A; CTG7A; PCQAP; TIG.1; TIG1; TNRC7
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [2]
3 Co-crystal Structure [7]
4 Reconstituted Complex [3]
5 Reconstituted Complex [7]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 23 (MED23) Interacting Protein Interacting Protein Info
UniProt ID
MED23_HUMAN 
Synonyms ARC130; CRSP130; CRSP133; CRSP3; DRIP130; MRT18; SUR.2; SUR2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-purification [3]
3 Reconstituted Complex [3]
4 Reconstituted Complex [7]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 1 (MED1) Interacting Protein Interacting Protein Info
UniProt ID
MED1_HUMAN 
Synonyms CRSP1; CRSP200; DRIP205; DRIP230; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-localization [7]
2 Co-purification [3]
3 Reconstituted Complex [7]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 12 (MED12) Interacting Protein Interacting Protein Info
UniProt ID
MED12_HUMAN 
Synonyms ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-purification [3]
3 Reconstituted Complex [7]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 13 (MED13) Interacting Protein Interacting Protein Info
UniProt ID
MED13_HUMAN 
Synonyms ARC250; DRIP250; HSPC221; THRAP1; TRAP240
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-purification [3]
3 Reconstituted Complex [7]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 14 (MED14) Interacting Protein Interacting Protein Info
UniProt ID
MED14_HUMAN 
Synonyms CRSP150; CRSP2; CSRP; CXorf4; DRIP150; EXLM1; RGR1; TRAP170
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-purification [3]
3 Reconstituted Complex [7]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 24 (MED24) Interacting Protein Interacting Protein Info
UniProt ID
MED24_HUMAN 
Synonyms ARC100; CRSP100; CRSP4; DRIP100; THRAP4; TRAP100
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-purification [3]
3 Reconstituted Complex [7]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 26 (MED26) Interacting Protein Interacting Protein Info
UniProt ID
MED26_HUMAN 
Synonyms CRSP7; CRSP70
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-purification [3]
3 Reconstituted Complex [7]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 6 (MED6) Interacting Protein Interacting Protein Info
UniProt ID
MED6_HUMAN 
Synonyms ARC33; NY.REN.28
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-purification [3]
3 Reconstituted Complex [7]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 7 (MED7) Interacting Protein Interacting Protein Info
UniProt ID
MED7_HUMAN 
Synonyms ARC34; CRSP33; CRSP9
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-purification [3]
3 Reconstituted Complex [3]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 17 (MED17) Interacting Protein Interacting Protein Info
UniProt ID
MED17_HUMAN 
Synonyms CRSP6; CRSP77; DRIP80; TRAP80
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Reconstituted Complex [7]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 25 (MED25) Interacting Protein Interacting Protein Info
UniProt ID
MED25_HUMAN 
Synonyms ACID1; ARC92; CMT2B2; P78; PTOV2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Reconstituted Complex [7]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Co-localization [7]
3 Co-purification [3]
4 Reconstituted Complex [3]
5 Reconstituted Complex [7]
6 Reconstituted Complex [9]
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-purification [3]
2 Reconstituted Complex [10]
References  Top
REF 1 Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors. Mol Cell Biol. 2003 Apr;23(7):2587-99.
REF 2 Activator-Mediator binding regulates Mediator-cofactor interactions. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11283-8.
REF 3 Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature. 1999 Apr 29;398(6730):828-32.
REF 4 SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. J Biol Chem. 2010 Oct 29;285(44):33959-70.
REF 5 Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010 Jul 1;24(13):1403-17.
REF 6 Structure, function, and activator-induced conformations of the CRSP coactivator. Science. 2002 Feb 8;295(5557):1058-62.
REF 7 An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature. 2006 Aug 10;442(7103):700-4.
REF 8 SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein. Genes Dev. 1996 Nov 15;10(22):2903-11.
REF 9 Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro. Genes Dev. 1998 Oct 1;12(19):3020-31.
REF 10 Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein. J Biol Chem. 1999 May 7;274(19):13025-32.

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