| Patent(s) and the Corresponding Patented Drug(s) |
Top |
| World Intellectual Property Organization (WIPO) |
| Patent ID |
WO2013076090 |
| Title |
3-Phenyl-Isoquinolin-1(2H)-One Derivatives As Parp-1 Inhibitors. |
| Abstract |
There are provided substituted 3-phenyl-isoquinolin-1(2H)-one derivatives which selectively inhibit the activity of poly(ADP-ribose) polymerase PARP-1 with respect to poly(ADP-ribose) polymerase PARP-2. The compounds of the present invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds. |
| Applicant(s) |
Nerviano Medical Sciences S.R.L |
| Representative Drug(s) |
D0TD8R |
Drug Info
|
IC50 = 1100 nM |
[1] |
| Patent ID |
WO2009046205 |
| Title |
Parp Inhibitor Compounds, Compositions and Methods of Use. |
| Abstract |
The present invention relates to tetraaza phenalen-3-one compounds which inhibit poly (ADP-ribose) polymerase (PARP) and are useful in the chemosensitization of cancer therapeutics. The induction of peripheral neuropathy is a common side-effect of many of the conventional and newer chemotherapies. The present invention further provides means to reliably prevent or cure chemotherapy- induced neuropathy. The invention also relates to the use of the disclosed PARP inhibitor compounds in enhancing the efficacy of chemotherapeutic agents such as temozolomide. The invention also relates to the use of the disclosed PARP inhibitor compounds to radiosensitize tumor cells to ionizing radiation. The invention also relates to the use of the disclosed PARP inhibitor compounds for treatment of cancers with DNA repair defects. |
| Applicant(s) |
Eisai Inc |
| Representative Drug(s) |
D0F5TD |
Drug Info
|
N.A. |
[1] |
| Taiwan Intellectual Property Office (TIPO) |
| Patent ID |
TW201444842 |
| Title |
Fused Tetra or Penta-Cyclic Dihydrodiazepinocarbazolones As Parp Inhibitors. |
| Applicant(s) |
Beigene Ltd |
| Representative Drug(s) |
D0P3YA |
Drug Info
|
IC50 = 0.2 nM |
[1] |
| Patent ID |
TW201444839 |
| Title |
Fused Tetra or Penta-Cyclic Pyridophthalazinones As Parp Inhibitors. |
| Applicant(s) |
Beigene Ltd |
| Representative Drug(s) |
D0Z8IR |
Drug Info
|
IC50 = 0.5 nM |
[1] |
