Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0Z8IR
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| Drug Name |
Tetra-cyclic pyridophthalazinone derivative 1
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| Synonyms |
PMID27841036-Compound-25
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| Drug Type |
Small molecular drug
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| Company |
BeiGene Ltd
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| Structure |
 |
Download2D MOL |
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Poly [ADP-ribose] polymerase 1 (PARP1) | Target Info | Inhibitor | [1] |
| Poly [ADP-ribose] polymerase 2 (PARP2) | Target Info | Inhibitor | [1] | |
| Target's Patent Info | Poly [ADP-ribose] polymerase 1 (PARP1) | Target's Patent Info | [1] | |
| Poly [ADP-ribose] polymerase 2 (PARP2) | Target's Patent Info | [1] | ||
| KEGG Pathway | Base excision repair | |||
| NF-kappa B signaling pathway | ||||
| Apoptosis | ||||
| Necroptosis | ||||
| Panther Pathway | FAS signaling pathway | |||
| Pathway Interaction Database | Integrin-linked kinase signaling | |||
| Caspase Cascade in Apoptosis | ||||
| Notch-mediated HES/HEY network | ||||
| Reactome | Dual Incision in GG-NER | |||
| WikiPathways | FAS pathway and Stress induction of HSP regulation | |||
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | ||||
| Nanoparticle triggered regulated necrosis | ||||
| Corticotropin-releasing hormone | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. | |||
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