Drug Information
Drug General Information | Top | |||
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Drug ID |
D0TD8R
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Drug Name |
3-phenyl isoquinolin-1(2H) derivative 1
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Synonyms |
PMID27841036-Compound-20
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Drug Type |
Small molecular drug
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Company |
NERVIANO MEDICAL SCIENCES S.R.L
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Structure |
Download2D MOL |
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Formula |
C17H15BrClFN2O2
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Canonical SMILES |
C1=CC(=CC=C1C2=C(C3=C(C=C(C=C3)F)C(=O)N2)OCCN)Br.Cl
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InChI |
1S/C17H14BrFN2O2.ClH/c18-11-3-1-10(2-4-11)15-16(23-8-7-20)13-6-5-12(19)9-14(13)17(22)21-15;/h1-6,9H,7-8,20H2,(H,21,22);1H
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InChIKey |
BSCLHAQBYMRPSH-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Poly [ADP-ribose] polymerase 1 (PARP1) | Target Info | Inhibitor | [1] |
Poly [ADP-ribose] polymerase 2 (PARP2) | Target Info | Inhibitor | [1] | |
Poly [ADP-ribose] polymerase 3 (PARP3) | Target Info | Inhibitor | [1] | |
Target's Patent Info | Poly [ADP-ribose] polymerase 1 (PARP1) | Target's Patent Info | [1] | |
Poly [ADP-ribose] polymerase 2 (PARP2) | Target's Patent Info | [1] | ||
Poly [ADP-ribose] polymerase 3 (PARP3) | Target's Patent Info | [1] | ||
KEGG Pathway | Base excision repair | |||
Apoptosis | ||||
Necroptosis | ||||
NF-kappa B signaling pathway | ||||
Panther Pathway | FAS signaling pathway | |||
Pathway Interaction Database | Integrin-linked kinase signaling | |||
Caspase Cascade in Apoptosis | ||||
Notch-mediated HES/HEY network | ||||
Reactome | Dual Incision in GG-NER | |||
WikiPathways | FAS pathway and Stress induction of HSP regulation | |||
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | ||||
Nanoparticle triggered regulated necrosis | ||||
Corticotropin-releasing hormone |
References | Top | |||
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REF 1 | PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. |
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