Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0P3YA
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| Drug Name |
Dihydrodiazepinocarbazolone derivative 1
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| Synonyms |
PMID27841036-Compound-26
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| Drug Type |
Small molecular drug
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| Company |
BeiGene Ltd
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| Structure |
 |
Download2D MOL |
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| Formula |
C22H28N4O
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| Canonical SMILES |
CC1(CC2=C3C(=NNC(=O)C4=C3C(=CC=C4)N2CCN5CCCCC5)C1)C
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| InChI |
1S/C22H28N4O/c1-22(2)13-16-20-18(14-22)26(12-11-25-9-4-3-5-10-25)17-8-6-7-15(19(17)20)21(27)24-23-16/h6-8H,3-5,9-14H2,1-2H3,(H,24,27)
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| InChIKey |
LNWPRZVIPZXIHL-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Poly [ADP-ribose] polymerase 1 (PARP1) | Target Info | Inhibitor | [1] |
| Poly [ADP-ribose] polymerase 2 (PARP2) | Target Info | Inhibitor | [1] | |
| Target's Patent Info | Poly [ADP-ribose] polymerase 1 (PARP1) | Target's Patent Info | [1] | |
| Poly [ADP-ribose] polymerase 2 (PARP2) | Target's Patent Info | [1] | ||
| KEGG Pathway | Base excision repair | |||
| NF-kappa B signaling pathway | ||||
| Apoptosis | ||||
| Necroptosis | ||||
| Panther Pathway | FAS signaling pathway | |||
| Pathway Interaction Database | Integrin-linked kinase signaling | |||
| Caspase Cascade in Apoptosis | ||||
| Notch-mediated HES/HEY network | ||||
| Reactome | Dual Incision in GG-NER | |||
| WikiPathways | FAS pathway and Stress induction of HSP regulation | |||
| Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | ||||
| Nanoparticle triggered regulated necrosis | ||||
| Corticotropin-releasing hormone | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382. | |||
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