Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T33641 Target Info
Target Name Cholesterol 24-hydroxylase (CYP46A1)
Synonyms Cytochrome P450 46A1; CYP46; Cholesterol 24S-hydroxylase; Cholesterol 24-monooxygenase; CH24H
Target Type Clinical trial Target
Gene Name CYP46A1
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
CP46A_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2014061676
Title Heterocyclic Compound.
Abstract Provided is a compound useful as a prophylactic or therapeutic agent for neurodegenerative diseases and others or a salt of the compound. The present invention relates to a compound represented by formula (I) [wherein each symbol is as defined in the description] or a salt thereof.
Applicant(s) Takeda Pharmaceutical Co. Ltd.
Representative Drug(s) D05TMN Drug Info 89% inhibition = 1000 nM Click to Show More [1]
2 D08HYS Drug Info 91% inhibition = 1000 nM [1]
3 D09RTV Drug Info 96% inhibition = 1000 nM [1]
4 D0LW9K Drug Info 82% inhibition = 1000 nM [1]
5 D0RY9R Drug Info 89% inhibition = 1000 nM [1]
6 D0SQ4B Drug Info 87% inhibition = 1000 nM [1]
7 D01EEY Drug Info N.A. [1]
8 D0M4XO Drug Info N.A. [1]
Patent ID WO13054822
Title Heterocyclic Compounds.
Applicant(s) Takeda Pharmaceutical Co. Ltd
Representative Drug(s) D0L5NZ Drug Info N.A. [1]
Patent ID WO10110400
Title Heterocyclic Compound.
Applicant(s) Takeda Pharmaceutical Co. Ltd
Representative Drug(s) D0XJ3S Drug Info N.A. [1]
References  Top
REF 1 Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676).Expert Opin Ther Pat. 2015 Mar;25(3):373-7.

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