Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D08HYS
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| Drug Name |
PMID25514969-Compound-10
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| Drug Type |
Small molecular drug
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| Company |
Takeda Pharmaceutical Co. Ltd
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| Structure |
 |
Download2D MOL |
||
| Formula |
C20H20N4O3
|
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| Canonical SMILES |
C1CC1C2=CN3C(=CN=C3C(=C2)C4=CN=CO4)C(=O)N5C6CCC5COC6
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| InChI |
1S/C20H20N4O3/c25-20(24-14-3-4-15(24)10-26-9-14)17-6-22-19-16(18-7-21-11-27-18)5-13(8-23(17)19)12-1-2-12/h5-8,11-12,14-15H,1-4,9-10H2
|
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| InChIKey |
SESFIBLYIKNNRP-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cholesterol 24-hydroxylase (CYP46A1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Cholesterol 24-hydroxylase (CYP46A1) | Target's Patent Info | [1] | |
| KEGG Pathway | Primary bile acid biosynthesis | |||
| Pathwhiz Pathway | Bile Acid Biosynthesis | |||
| Reactome | Endogenous sterols | |||
| WikiPathways | Metapathway biotransformation | |||
| Oxidation by Cytochrome P450 | ||||
| Phase 1 - Functionalization of compounds | ||||
| Bile acid and bile salt metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676).Expert Opin Ther Pat. 2015 Mar;25(3):373-7. | |||
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