Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0L5NZ
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| Drug Name |
PMID25514969-Compound-Figure2-3
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| Drug Type |
Small molecular drug
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| Company |
Takeda Pharmaceutical Co. Ltd
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| Structure |
 |
Download2D MOL |
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| Formula |
C23H23N3O2
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| Canonical SMILES |
C1CN(CCC1(CC2=CC=CC=C2)O)C(=O)C3=C(N=CC=C3)C4=CC=NC=C4
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| InChI |
1S/C23H23N3O2/c27-22(20-7-4-12-25-21(20)19-8-13-24-14-9-19)26-15-10-23(28,11-16-26)17-18-5-2-1-3-6-18/h1-9,12-14,28H,10-11,15-17H2
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| InChIKey |
XKUZMIUSBMCVPP-UHFFFAOYSA-N
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| CAS Number |
CAS 1429505-03-2
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Cholesterol 24-hydroxylase (CYP46A1) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Cholesterol 24-hydroxylase (CYP46A1) | Target's Patent Info | [1] | |
| KEGG Pathway | Primary bile acid biosynthesis | |||
| Pathwhiz Pathway | Bile Acid Biosynthesis | |||
| Reactome | Endogenous sterols | |||
| WikiPathways | Metapathway biotransformation | |||
| Oxidation by Cytochrome P450 | ||||
| Phase 1 - Functionalization of compounds | ||||
| Bile acid and bile salt metabolism | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Imidazo[1,2-a]pyridines as cholesterol 24-hydroxylase (CYP46A1) inhibitors: a patent evaluation (WO2014061676).Expert Opin Ther Pat. 2015 Mar;25(3):373-7. | |||
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