miRNA General Information
miRNA Mature ID hsa-miR-99a-5p
miRNA Stemloop AC MI0000101
miRNA Stemloop ID hsa-mir-99a
Sequence aacccguagauccgaucuugug
TTD Target(s) Regulated by This miRNA Serine/threonine-protein kinase mTOR (mTOR) Successful Target Target Info [1]
Insulin-like growth factor I receptor (IGF1R) Successful Target Target Info [1]
Fibroblast growth factor receptor 3 (FGFR3) Successful Target Target Info [2]
RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Target Info [3]
Endothelial plasminogen activator inhibitor (SERPINE1) Clinical trial Target Target Info [4]
NADPH oxidase 4 (NOX4) Clinical trial Target Target Info [5]
FK506-binding protein 5 (FKBP5) Literature-reported Target Target Info [6]
Protein(s) Regulated by This miRNA Calpain small subunit 1 Regulated Protein [7]
CTD small phosphatase-like protein Regulated Protein [8]
Grainyhead-like protein 1 homolog Regulated Protein [9]
Homeobox protein Hox-A1 Regulated Protein [10]
Myotubularin-related protein 3 Regulated Protein [11]
Protein argonaute-2 Regulated Protein [12]
Ribonucleoprotein PTB-binding 2 Regulated Protein [13]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit Regulated Protein [9]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Regulated Protein [14]
Tribbles homolog 2 Regulated Protein [8]
References
REF 1 Regulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumors. Cancer Res. 2010 Jun 1;70(11):4666-75.
REF 2 Decreased expression of miR-125b and miR-100 in oral cancer cells contributes to malignancy. Genes Chromosomes Cancer. 2009 Jul;48(7):569-82.
REF 3 miR-99a suppresses the metastasis of human non-small cell lung cancer cells by targeting AKT1 signaling pathway. J Cell Biochem. 2015 Feb;116(2):268-76.
REF 4 Involvement of miR-30c and miR-301a in immediate induction of plasminogen activator inhibitor-1 by placental growth factor in human pulmonary endothelial cells. Biochem J. 2011 Mar 15;434(3):473-82.
REF 5 MiR-99a regulates ROS-mediated invasion and migration of lung adenocarcinoma cells by targeting NOX4. Oncol Rep. 2016 May;35(5):2755-66.
REF 6 MicroRNA-100/99a, deregulated in acute lymphoblastic leukaemia, suppress proliferation and promote apoptosis by regulating the FKBP51 and IGF1R/mTOR signalling pathways. Br J Cancer. 2013 Oct 15;109(8):2189-98.
REF 7 MiR-99a and MiR-491 Regulate Cisplatin Resistance in Human Gastric Cancer Cells by Targeting CAPNS1. Int J Biol Sci. 2016 Nov 5;12(12):1437-1447.
REF 8 MiR-99a may serve as a potential oncogene in pediatric myeloid leukemia.Cancer Cell Int. 2013 Nov 5;13(1):110.
REF 9 MicroRNA profiling in mucosal biopsies of eosinophilic esophagitis patients pre and post treatment with steroids and relationship with mRNA targets. PLoS One. 2012;7(7):e40676.
REF 10 MicroRNA-99 family members suppress Homeobox A1 expression in epithelial cells. PLoS One. 2013 Dec 3;8(12):e80625.
REF 11 MiR-99a exerts anti-metastasis through inhibiting myotubularin-related protein 3 expression in oral cancer.Oral Dis. 2014 Apr;20(3):e65-75.
REF 12 MiRNA-99a directly regulates AGO2 through translational repression in hepatocellular carcinoma.Oncogenesis. 2014 Apr 14;3:e97.
REF 13 Identification of human microRNA targets from isolated argonaute protein complexes.RNA Biol. 2007 Jun;4(2):76-84.
REF 14 The miR-99 family regulates the DNA damage response through its target SNF2H.Oncogene. 2013 Feb 28;32(9):1164-72.

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