Target and Pathway |
Top |
Target(s) |
Albendazole monooxygenase (CYP3A4) |
Target Info
|
Inhibitor |
[2] |
Cyclin-dependent kinase 2 (CDK2) |
Target Info
|
Inhibitor |
[1] |
ERBB2 messenger RNA (HER2 mRNA) |
Target Info
|
Inhibitor |
[1] |
Extracellular signal-regulated kinase 2 (ERK2) |
Target Info
|
Inhibitor |
[1] |
Focal adhesion kinase 1 (FAK) |
Target Info
|
Inhibitor |
[1] |
G1/S-specific cyclin-E1 (CCNE1) |
Target Info
|
Inhibitor |
[1] |
Insulin-like growth factor I receptor (IGF1R) |
Target Info
|
Inhibitor |
[3] |
LCK tyrosine protein kinase (LCK) |
Target Info
|
Inhibitor |
[1] |
Platelet-derived growth factor receptor alpha (PDGFRA) |
Target Info
|
Inhibitor |
[1] |
Platelet-derived growth factor receptor beta (PDGFRB) |
Target Info
|
Inhibitor |
[1] |
Proto-oncogene c-Met (MET) |
Target Info
|
Inhibitor |
[1] |
RAC-alpha serine/threonine-protein kinase (AKT1) |
Target Info
|
Inhibitor |
[1] |
Vascular endothelial growth factor receptor 2 (KDR) |
Target Info
|
Inhibitor |
[1] |
KEGG Pathway
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MAPK signaling pathway
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Ras signaling pathway
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Rap1 signaling pathway
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Calcium signaling pathway
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Cytokine-cytokine receptor interaction
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Endocytosis
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PI3K-Akt signaling pathway
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Focal adhesion
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Gap junction
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Regulation of actin cytoskeleton
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HTLV-I infection
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Pathways in cancer
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MicroRNAs in cancer
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Glioma
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Prostate cancer
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Melanoma
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Central carbon metabolism in cancer
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Choline metabolism in cancer
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ErbB signaling pathway
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cGMP-PKG signaling pathway
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cAMP signaling pathway
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Chemokine signaling pathway
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HIF-1 signaling pathway
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FoxO signaling pathway
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Sphingolipid signaling pathway
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mTOR signaling pathway
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AMPK signaling pathway
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Apoptosis
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Adrenergic signaling in cardiomyocytes
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VEGF signaling pathway
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Osteoclast differentiation
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Tight junction
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Signaling pathways regulating pluripotency of stem cells
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Platelet activation
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Toll-like receptor signaling pathway
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Jak-STAT signaling pathway
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T cell receptor signaling pathway
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B cell receptor signaling pathway
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Fc epsilon RI signaling pathway
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Fc gamma R-mediated phagocytosis
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TNF signaling pathway
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Neurotrophin signaling pathway
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Cholinergic synapse
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Dopaminergic synapse
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Insulin signaling pathway
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Progesterone-mediated oocyte maturation
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Estrogen signaling pathway
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Prolactin signaling pathway
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Thyroid hormone signaling pathway
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Adipocytokine signaling pathway
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Glucagon signaling pathway
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Regulation of lipolysis in adipocytes
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Non-alcoholic fatty liver disease (NAFLD)
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Carbohydrate digestion and absorption
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Tuberculosis
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Hepatitis C
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Hepatitis B
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Measles
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Influenza A
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Epstein-Barr virus infection
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Proteoglycans in cancer
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Colorectal cancer
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Renal cell carcinoma
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Pancreatic cancer
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Endometrial cancer
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Chronic myeloid leukemia
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Acute myeloid leukemia
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Small cell lung cancer
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Non-small cell lung cancer
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NF-kappa B signaling pathway
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Natural killer cell mediated cytotoxicity
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Primary immunodeficiency
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Axon guidance
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Adherens junction
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Bacterial invasion of epithelial cells
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Epithelial cell signaling in Helicobacter pylori infection
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Malaria
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Transcriptional misregulation in cancer
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Steroid hormone biosynthesis
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Linoleic acid metabolism
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Retinol metabolism
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Metabolism of xenobiotics by cytochrome P450
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Drug metabolism - cytochrome P450
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Drug metabolism - other enzymes
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Metabolic pathways
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Bile secretion
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Chemical carcinogenesis
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Cell cycle
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Oocyte meiosis
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p53 signaling pathway
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Viral carcinogenesis
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Leukocyte transendothelial migration
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Amoebiasis
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Long-term depression
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Ovarian steroidogenesis
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Vascular smooth muscle contraction
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Dorso-ventral axis formation
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TGF-beta signaling pathway
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NOD-like receptor signaling pathway
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Circadian entrainment
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Long-term potentiation
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Retrograde endocannabinoid signaling
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Glutamatergic synapse
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Serotonergic synapse
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GnRH signaling pathway
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Melanogenesis
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Oxytocin signaling pathway
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Type II diabetes mellitus
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Aldosterone-regulated sodium reabsorption
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Alzheimer's disease
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Prion diseases
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Alcoholism
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Shigellosis
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Salmonella infection
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Pertussis
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Leishmaniasis
|
Thyroid cancer
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Bladder cancer
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Herpes simplex infection
|
NetPath Pathway
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TGF_beta_Receptor Signaling Pathway
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TSH Signaling Pathway
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IL2 Signaling Pathway
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TCR Signaling Pathway
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Panther Pathway
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Angiogenesis
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PDGF signaling pathway
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Apoptosis signaling pathway
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EGF receptor signaling pathway
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Endothelin signaling pathway
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FGF signaling pathway
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Huntington disease
|
Hypoxia response via HIF activation
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Inflammation mediated by chemokine and cytokine signaling pathway
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Insulin/IGF pathway-protein kinase B signaling cascade
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Interleukin signaling pathway
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PI3 kinase pathway
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T cell activation
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VEGF signaling pathway
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p53 pathway
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Ras Pathway
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p53 pathway by glucose deprivation
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p53 pathway feedback loops 2
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CCKR signaling map ST
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Parkinson disease
|
Cell cycle
|
Integrin signalling pathway
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Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
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Alzheimer disease-amyloid secretase pathway
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B cell activation
|
Interferon-gamma signaling pathway
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TGF-beta signaling pathway
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Angiotensin II-stimulated signaling through G proteins and beta-arrestin
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Cadherin signaling pathway
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Pathwhiz Pathway
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Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
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Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
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Fc Epsilon Receptor I Signaling in Mast Cells
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Insulin Signalling
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Leucine Stimulation on Insulin Signaling
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Caffeine Metabolism
|
Retinol Metabolism
|
Phosphatidylinositol Phosphate Metabolism
|
Pathway Interaction Database
|
ATF-2 transcription factor network
|
PDGFR-alpha signaling pathway
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PDGF receptor signaling network
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Regulation of nuclear SMAD2/3 signaling
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Fc-epsilon receptor I signaling in mast cells
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Endothelins
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BCR signaling pathway
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LPA receptor mediated events
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Insulin Pathway
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IL4-mediated signaling events
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TCR signaling in naï
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Plasma membrane estrogen receptor signaling
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CD40/CD40L signaling
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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Signaling events mediated by PTP1B
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S1P3 pathway
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Coregulation of Androgen receptor activity
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Reelin signaling pathway
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Integrin-linked kinase signaling
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TCR signaling in naï
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Angiopoietin receptor Tie2-mediated signaling
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FAS (CD95) signaling pathway
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Thromboxane A2 receptor signaling
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Regulation of Telomerase
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FOXA2 and FOXA3 transcription factor networks
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Glucocorticoid receptor regulatory network
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mTOR signaling pathway
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CXCR4-mediated signaling events
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IGF1 pathway
|
FoxO family signaling
|
IL2 signaling events mediated by PI3K
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Ceramide signaling pathway
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p75(NTR)-mediated signaling
|
E-cadherin signaling in the nascent adherens junction
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amb2 Integrin signaling
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Integrins in angiogenesis
|
IFN-gamma pathway
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ErbB1 downstream signaling
|
ErbB2/ErbB3 signaling events
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IL6-mediated signaling events
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E-cadherin signaling in keratinocytes
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Nephrin/Neph1 signaling in the kidney podocyte
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Retinoic acid receptors-mediated signaling
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IL8- and CXCR2-mediated signaling events
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Signaling events mediated by the Hedgehog family
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Nongenotropic Androgen signaling
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Hedgehog signaling events mediated by Gli proteins
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Caspase Cascade in Apoptosis
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CXCR3-mediated signaling events
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VEGFR1 specific signals
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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Signaling events mediated by VEGFR1 and VEGFR2
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a6b1 and a6b4 Integrin signaling
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Aurora A signaling
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Insulin-mediated glucose transport
|
Class I PI3K signaling events mediated by Akt
|
IL8- and CXCR1-mediated signaling events
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HIF-1-alpha transcription factor network
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p53 pathway
|
Trk receptor signaling mediated by PI3K and PLC-gamma
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VEGFR3 signaling in lymphatic endothelium
|
FGF signaling pathway
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HIF-2-alpha transcription factor network
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Beta3 integrin cell surface interactions
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Signaling events mediated by TCPTP
|
SHP2 signaling
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S1P1 pathway
|
VEGF and VEGFR signaling network
|
Notch-mediated HES/HEY network
|
Atypical NF-kappaB pathway
|
Glypican 1 network
|
IL12-mediated signaling events
|
Regulation of p38-alpha and p38-beta
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IL2-mediated signaling events
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Class I PI3K signaling events
|
EPHA forward signaling
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PDGFR-beta signaling pathway
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IL2 signaling events mediated by STAT5
|
Ephrin B reverse signaling
|
Alpha-synuclein signaling
|
Arf6 signaling events
|
Posttranslational regulation of adherens junction stability and dissassembly
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Direct p53 effectors
|
Syndecan-1-mediated signaling events
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Stabilization and expansion of the E-cadherin adherens junction
|
Regulation of retinoblastoma protein
|
Signaling events mediated by PRL
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E2F transcription factor network
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FOXM1 transcription factor network
|
BARD1 signaling events
|
PLK3 signaling events
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Nectin adhesion pathway
|
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
Validated targets of C-MYC transcriptional repression
|
ErbB4 signaling events
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GMCSF-mediated signaling events
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EPHB forward signaling
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Osteopontin-mediated events
|
S1P4 pathway
|
Presenilin action in Notch and Wnt signaling
|
TRAIL signaling pathway
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CDC42 signaling events
|
Signaling events regulated by Ret tyrosine kinase
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Netrin-mediated signaling events
|
Arf6 downstream pathway
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Class IB PI3K non-lipid kinase events
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EGF receptor (ErbB1) signaling pathway
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Ras signaling in the CD4+ TCR pathway
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BMP receptor signaling
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ALK1 signaling events
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Neurotrophic factor-mediated Trk receptor signaling
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Regulation of cytoplasmic and nuclear SMAD2/3 signaling
|
Syndecan-2-mediated signaling events
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Cellular roles of Anthrax toxin
|
S1P2 pathway
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Trk receptor signaling mediated by the MAPK pathway
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Downstream signaling in naï
|
Signaling events mediated by focal adhesion kinase
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p73 transcription factor network
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ATR signaling pathway
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ErbB receptor signaling network
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Reactome
|
PIP3 activates AKT signaling
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Constitutive Signaling by Aberrant PI3K in Cancer
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RAF/MAP kinase cascade
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Activation of BAD and translocation to mitochondria
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GPVI-mediated activation cascade
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Translocation of GLUT4 to the plasma membrane
|
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
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AKT phosphorylates targets in the cytosol
|
AKT phosphorylates targets in the nucleus
|
Negative regulation of the PI3K/AKT network
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eNOS activation
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AKT-mediated inactivation of FOXO1A
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Integrin alphaIIb beta3 signaling
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Deactivation of the beta-catenin transactivating complex
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CD28 dependent PI3K/Akt signaling
|
CTLA4 inhibitory signaling
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G beta:gamma signalling through PI3Kgamma
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KSRP (KHSRP) binds and destabilizes mRNA
|
VEGFR2 mediated vascular permeability
|
TP53 Regulates Metabolic Genes
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Constitutive Signaling by AKT1 E17K in Cancer
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Neurophilin interactions with VEGF and VEGFR
|
VEGF binds to VEGFR leading to receptor dimerization
|
Integrin cell surface interactions
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EPHA-mediated growth cone collapse
|
VEGFA-VEGFR2 Pathway
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VEGFR2 mediated cell proliferation
|
Regulation of KIT signaling
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Phosphorylation of CD3 and TCR zeta chains
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Translocation of ZAP-70 to Immunological synapse
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Generation of second messenger molecules
|
PECAM1 interactions
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DAP12 signaling
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CD28 co-stimulation
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CD28 dependent Vav1 pathway
|
PD-1 signaling
|
Interleukin-2 signaling
|
Sema4D mediated inhibition of cell attachment and migration
|
Xenobiotics
|
Aflatoxin activation and detoxification
|
E2F mediated regulation of DNA replication
|
G0 and Early G1
|
SCF(Skp2)-mediated degradation of p27/p21
|
DNA Damage/Telomere Stress Induced Senescence
|
Cyclin E associated events during G1/S transition
|
G1/S-Specific Transcription
|
p53-Dependent G1 DNA Damage Response
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Apoptotic cleavage of cellular proteins
|
Regulation of actin dynamics for phagocytic cup formation
|
GRB2:SOS provides linkage to MAPK signaling for Integrins
|
p130Cas linkage to MAPK signaling for integrins
|
NCAM signaling for neurite out-growth
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Signal regulatory protein (SIRP) family interactions
|
EPHB-mediated forward signaling
|
DCC mediated attractive signaling
|
Netrin mediated repulsion signals
|
RHO GTPases Activate WASPs and WAVEs
|
IRS-related events triggered by IGF1R
|
SHC-related events triggered by IGF1R
|
RAF-independent MAPK1/3 activation
|
MAPK1 (ERK2) activation
|
Golgi Cisternae Pericentriolar Stack Reorganization
|
ERK/MAPK targets
|
Oxidative Stress Induced Senescence
|
Senescence-Associated Secretory Phenotype (SASP)
|
Oncogene Induced Senescence
|
FCERI mediated MAPK activation
|
Regulation of HSF1-mediated heat shock response
|
Recycling pathway of L1
|
CREB phosphorylation through the activation of Ras
|
Activation of the AP-1 family of transcription factors
|
Thrombin signalling through proteinase activated receptors (PARs)
|
Negative regulation of FGFR1 signaling
|
Negative regulation of FGFR2 signaling
|
Negative regulation of FGFR3 signaling
|
Negative regulation of FGFR4 signaling
|
MAP2K and MAPK activation
|
Negative feedback regulation of MAPK pathway
|
Negative regulation of MAPK pathway
|
Signal attenuation
|
Advanced glycosylation endproduct receptor signaling
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
Growth hormone receptor signaling
|
Activation of ATR in response to replication stress
|
Regulation of APC/C activators between G1/S and early anaphase
|
Processing of DNA double-strand break ends
|
G2 Phase
|
Orc1 removal from chromatin
|
Cyclin A/B1 associated events during G2/M transition
|
Cyclin A:Cdk2-associated events at S phase entry
|
Meiotic recombination
|
Factors involved in megakaryocyte development and platelet production
|
SHC1 events in ERBB2 signaling
|
PLCG1 events in ERBB2 signaling
|
GRB2 events in ERBB2 signaling
|
PI3K events in ERBB2 signaling
|
Sema4D induced cell migration and growth-cone collapse
|
WikiPathways
|
Regulation of Actin Cytoskeleton
|
Osteoblast Signaling
|
Focal Adhesion
|
Hair Follicle Development: Organogenesis (Part 2 of 3)
|
PIP3 activates AKT signaling
|
Cardiac Progenitor Differentiation
|
Integrated Pancreatic Cancer Pathway
|
Allograft Rejection
|
Signaling Pathways in Glioblastoma
|
Signaling by PDGF
|
Angiogenesis
|
Toll-like receptor signaling pathway
|
DNA Damage Response (only ATM dependent)
|
TCR Signaling Pathway
|
Notch Signaling Pathway
|
EPO Receptor Signaling
|
IL-2 Signaling Pathway
|
Insulin Signaling
|
Endochondral Ossification
|
EGF/EGFR Signaling Pathway
|
IL-4 Signaling Pathway
|
TGF beta Signaling Pathway
|
IL-6 signaling pathway
|
Wnt Signaling Pathway Netpath
|
Copper homeostasis
|
Extracellular vesicle-mediated signaling in recipient cells
|
Apoptosis-related network due to altered Notch3 in ovarian cancer
|
IL-3 Signaling Pathway
|
Cardiac Hypertrophic Response
|
Translocation of GLUT4 to the Plasma Membrane
|
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
|
Signal Transduction of S1P Receptor
|
T-Cell Receptor and Co-stimulatory Signaling
|
Primary Focal Segmental Glomerulosclerosis FSGS
|
Apoptosis
|
Alpha 6 Beta 4 signaling pathway
|
BDNF signaling pathway
|
Oncostatin M Signaling Pathway
|
Corticotropin-releasing hormone
|
Interleukin-11 Signaling Pathway
|
AGE/RAGE pathway
|
TNF alpha Signaling Pathway
|
B Cell Receptor Signaling Pathway
|
Prostate Cancer
|
TSLP Signaling Pathway
|
IL17 signaling pathway
|
IL-7 Signaling Pathway
|
Regulation of Microtubule Cytoskeleton
|
TWEAK Signaling Pathway
|
FSH signaling pathway
|
Leptin signaling pathway
|
TSH signaling pathway
|
RANKL/RANK Signaling Pathway
|
Integrated Breast Cancer Pathway
|
SREBP signalling
|
Integrated Cancer pathway
|
IL-1 signaling pathway
|
Metabolism of nitric oxide
|
Integrin-mediated Cell Adhesion
|
TFs Regulate miRNAs related to cardiac hypertrophy
|
MicroRNAs in cardiomyocyte hypertrophy
|
TOR Signaling
|
Regulation of toll-like receptor signaling pathway
|
AMPK Signaling
|
Androgen receptor signaling pathway
|
IL-5 Signaling Pathway
|
Nifedipine Activity
|
Signaling by VEGF
|
Interferon type I signaling pathways
|
Inflammatory Response Pathway
|
Signaling by SCF-KIT
|
DAP12 interactions
|
Host Interactions of HIV factors
|
TCR signaling
|
Costimulation by the CD28 family
|
Signaling of Hepatocyte Growth Factor Receptor
|
miR-targeted genes in squamous cell - TarBase
|
miR-targeted genes in muscle cell - TarBase
|
miR-targeted genes in lymphocytes - TarBase
|
miR-targeted genes in epithelium - TarBase
|
Semaphorin interactions
|
Metapathway biotransformation
|
Aflatoxin B1 metabolism
|
Estrogen metabolism
|
Benzo(a)pyrene metabolism
|
Tamoxifen metabolism
|
Tryptophan metabolism
|
Oxidation by Cytochrome P450
|
Nuclear Receptors in Lipid Metabolism and Toxicity
|
Nuclear Receptors Meta-Pathway
|
Farnesoid X Receptor Pathway
|
Vitamin D Receptor Pathway
|
Felbamate Metabolism
|
Lidocaine metabolism
|
Colchicine Metabolic Pathway
|
Irinotecan Pathway
|
Drug Induction of Bile Acid Pathway
|
Fatty Acid Omega Oxidation
|
Codeine and Morphine Metabolism
|
DNA Damage Response
|
ID signaling pathway
|
G1 to S cell cycle control
|
Retinoblastoma (RB) in Cancer
|
Parkinsons Disease Pathway
|
Parkin-Ubiquitin Proteasomal System pathway
|
Mitotic G1-G1/S phases
|
Cell Cycle
|
miRNAs involved in DNA damage response
|
miRNA Regulation of DNA Damage Response
|
Nanoparticle-mediated activation of receptor signaling
|
JAK/STAT
|
Netrin-1 signaling
|
NCAM signaling for neurite out-growth
|
Integrin alphaIIb beta3 signaling
|
Apoptotic execution phase
|
MAPK Signaling Pathway
|
PDGF Pathway
|
Senescence and Autophagy in Cancer
|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
Serotonin Receptor 4/6/7 and NR3C Signaling
|
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
Serotonin HTR1 Group and FOS Pathway
|
Vitamin A and Carotenoid Metabolism
|
ErbB Signaling Pathway
|
Hypothetical Network for Drug Addiction
|
MAPK Cascade
|
Kit receptor signaling pathway
|
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
|
Bladder Cancer
|
MAP kinase activation in TLR cascade
|
Fc epsilon receptor (FCERI) signaling
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
RAF/MAP kinase cascade
|
Structural Pathway of Interleukin 1 (IL-1)
|
Genes and (Common) Pathways Underlying Drug Addiction
|
EBV LMP1 signaling
|
Aryl Hydrocarbon Receptor
|
Spinal Cord Injury
|
IL-9 Signaling Pathway
|
Endothelin Pathways
|
Alzheimers Disease
|
Opioid Signalling
|
Thrombin signalling through proteinase activated receptors (PARs)
|
Signaling by FGFR
|
L1CAM interactions
|
Advanced glycosylation endproduct receptor signaling
|
Heart Development
|
Type II diabetes mellitus
|
Physiological and Pathological Hypertrophy of the Heart
|
Osteopontin Signaling
|
DNA Replication
|
M/G1 Transition
|
S Phase
|
Meiotic Recombination
|
ATM Signaling Pathway
|
Synthesis of DNA
|
Regulation of DNA replication
|
Mitotic G2-G2/M phases
|
Factors involved in megakaryocyte development and platelet production
|
APC/C-mediated degradation of cell cycle proteins
|
Cell Cycle Checkpoints
|
Signaling by ERBB2
|