Co-Target(s) Information

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Target General Information
Co-Targets of This Target
References
Target General Information  Top
Target ID T36557 Target Info
Target Name Peroxisome proliferator-activated receptor delta (PPARD)
Synonyms
Peroxisomeproliferator-activated receptor beta; Peroxisomeproliferator activated receptor beta/delta; Peroxisome proliferator-activated receptor beta; PPARdelta; PPARB; PPAR-delta; PPAR-beta; Nuclear receptor subfamily 1 group C member 2; Nuclear hormone receptor 1; NUCI; NUC1; NR1C2
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Target Type Clinical trial Target
Gene Name PPARD
Biochemical Class Nuclear hormone receptor
UniProt ID
PPARD_HUMAN
Co-Targets of This Target  Top
Co-Target Name Peroxisome proliferator-activated receptor alpha (PPARA) Successful Target
UniProt ID PPARA_HUMAN
Gene Name PPARA
Synonyms
Peroxisome proliferater-activated receptor alpha; PPARalpha; PPAR-alpha; PPAR; Nuclear receptor subfamily 1 group C member 1; NR1C1
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Representative Drug(s) GFT-505 Drug Info EC50 = 10 nM Click to Show More [1]
2 MBX-8025 Drug Info EC50 ~ 1000 nM [2]
Co-Target Name Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Successful Target
UniProt ID PPARG_HUMAN
Gene Name PPARG
Synonyms
PPAR-gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
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Representative Drug(s) MBX-8025 Drug Info EC50 ~ 1000 nM [2]
References  Top
REF 1 The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease. J Med Chem. 2020 May 28;63(10):5031-5073.
REF 2 Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3855-9.

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