| Target Validation Information | |||||
|---|---|---|---|---|---|
| Target ID | T52297 | ||||
| Target Name | Oxysterols receptor LXR-alpha | ||||
| Target Type | Research |
||||
| Drug Potency against Target | 12-dehydroxyriccardin C | Drug Info | IC50 = 4400 nM | [529375] | |
| 2-(2-phenethylphenyl)isoindoline-1,3-dione | Drug Info | IC50 = 9800 nM | [530220] | ||
| GW-3965 | Drug Info | IC50 = 100 nM | [529781] | ||
| WAY-252623 | Drug Info | IC50 = 179 nM | [529781] | ||
| 12,17-dehydroxyriccardin C | Drug Info | IC50 = 5700 nM | [529375] | ||
| 2-(2-hexylphenyl)isoindoline-1,3-dione | Drug Info | IC50 = 13000 nM | [529375] | ||
| 4,17-dehydroxyriccardin C | Drug Info | IC50 = 3200 nM | [529375] | ||
| 4,12,17-dehydroxyriccardin C | Drug Info | IC50 = 7100 nM | [529375] | ||
| GSK-9772 | Drug Info | IC50 = 180 nM | [529702] | ||
| WAY-214950 | Drug Info | IC50 = 248 nM | [529781] | ||
| 2-Benzyl-3-phenyl-7-(trifluoromethyl)-2H-indazole | Drug Info | IC50 = 279 nM | [529781] | ||
| Guttiferone I | Drug Info | IC50 = 3400 nM | [527525] | ||
| 4-dehydroxyriccardin C | Drug Info | IC50 = 8400 nM | [529375] | ||
| 17-dehydroxyriccardin C | Drug Info | IC50 = 6600 nM | [529375] | ||
| Riccardin C | Drug Info | IC50 = 4900 nM | [529375] | ||
| References | |||||
| Ref 529375 | Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | ||||
| Ref 530220 | Bioorg Med Chem. 2009 Jul 15;17(14):5001-14. Epub 2009 Jun 2.Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists. | ||||
| Ref 529781 | J Med Chem. 2008 Nov 27;51(22):7161-8.Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis. | ||||
| Ref 529781 | J Med Chem. 2008 Nov 27;51(22):7161-8.Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis. | ||||
| Ref 529375 | Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | ||||
| Ref 529375 | Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | ||||
| Ref 529375 | Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | ||||
| Ref 529375 | Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | ||||
| Ref 529702 | J Med Chem. 2008 Sep 25;51(18):5758-65.Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. | ||||
| Ref 529781 | J Med Chem. 2008 Nov 27;51(22):7161-8.Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis. | ||||
| Ref 529781 | J Med Chem. 2008 Nov 27;51(22):7161-8.Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis. | ||||
| Ref 527525 | J Nat Prod. 2005 Apr;68(4):617-9.Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand. | ||||
| Ref 529375 | Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | ||||
| Ref 529375 | Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | ||||
| Ref 529375 | Bioorg Med Chem. 2008 Apr 15;16(8):4272-85. Epub 2008 Feb 29.Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. | ||||
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