Drug Information

Drug General Information
Drug ID
D00DLU
Former ID
DNC008969
Drug Name
GSK-9772
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543250]
Structure
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2D MOL

3D MOL
Formula
C20H19Cl2F6NO2
InChI
InChI=1S/C20H19Cl2F6NO2/c1-2-3-8-29(11-12-9-15(21)17(30)16(22)10-12)14-6-4-13(5-7-14)18(31,19(23,24)25)20(26,27)28/h4-7,9-10,30-31H,2-3,8,11H2,1H3
InChIKey
TYYLMKBOWXDDCT-UHFFFAOYSA-N
PubChem Compound ID
16049480
PubChem Substance ID
24435812, 26594792, 29614141, 103604658, 104105640, 134346174, 141777365, 163778883, 230540445, 247977161, 252166893
Target and Pathway
Target(s) Oxysterols receptor LXR-alpha Target Info Inhibitor [529702]
Oxysterols receptor LXR-beta Target Info Inhibitor [529702]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathway
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear ReceptorsWP1982:SREBP signalling
Nuclear Receptors
References
Ref 543250(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8693).
Ref 529702J Med Chem. 2008 Sep 25;51(18):5758-65.Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.

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