Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0PL4F
|
||||
| Former ID |
DNC006893
|
||||
| Drug Name |
GW-3965
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C33H31ClF3NO3
|
||||
| InChI |
InChI=1S/C33H31ClF3NO3/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40)
|
||||
| InChIKey |
NAXSRXHZFIBFMI-UHFFFAOYSA-N
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID |
829748, 7885550, 10300132, 14911410, 17396621, 26755460, 36889920, 46519987, 53787809, 57404840, 78372800, 85788706, 92728670, 93578094, 103249137, 104638678, 124892359, 127337902, 127337903, 127337904, 134344098, 135325764, 135650333, 136367927, 136946547, 137183401, 139769446, 144115385, 144116041, 151995567, 152258261, 160647097, 171578606, 172650060, 172659554, 179317066, 185989924, 198939615, 223397282, 223445164, 223943816, 228248894, 241080729, 247228919, 252215521
|
||||
| Target and Pathway | |||||
| Target(s) | Oxysterols receptor LXR-beta | Target Info | Inhibitor | [2] | |
| Oxysterols receptor LXR-alpha | Target Info | Inhibitor | [2] | ||
| KEGG Pathway | PPAR signaling pathway | ||||
| Non-alcoholic fatty liver disease (NAFLD) | |||||
| Hepatitis C | |||||
| Pathway Interaction Database | RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor | ||||
| Reactome | Nuclear Receptor transcription pathway | ||||
| WikiPathways | SREBP signalling | ||||
| Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity | |||||
| Nuclear Receptors Meta-Pathway | |||||
| PPAR Alpha Pathway | |||||
| Liver X Receptor Pathway | |||||
| Adipogenesis | |||||
| SREBF and miR33 in cholesterol and lipid homeostasis | |||||
| Nuclear Receptors | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2754). | ||||
| REF 2 | J Med Chem. 2008 Nov 27;51(22):7161-8.Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.