Target Validation Information
Target ID T76369
Target Name Liver carboxylesterase
Target Type
Successful
Drug Potency against Target BENZOIN Drug Info Ki = 7210 nM [528766]
5,7-dichloro-1H-indole-2,3-dione Drug Info Ki = 3520 nM [528749]
(E)-Octadec-9-enoic acid phenylamide Drug Info IC50 = 170 nM [527138]
3,4,5,6-Tetrachloro-[1,2]benzoquinone Drug Info Ki = 5440 nM [527510]
11,12-dihydro-dibenzo[a,e]cyclooctene-5,6-dione Drug Info Ki = 2980 nM [529103]
Thieno[3,2-e][1]benzothiophene-4,5-dione Drug Info Ki = 150 nM [529103]
1,2-indanedione Drug Info Ki = 5240 nM [529103]
Phenanthrene-9,10-dione Drug Info Ki = 2.5 nM [529103]
ACENAPHTHOQUINONE Drug Info Ki = 31 nM [529103]
CHLORANIL Drug Info Ki = 83.9 nM [527510]
1-benzyl-1H-indole-2,3-dione Drug Info Ki = 1700 nM [528749]
4,5-dichloro-1H-indole-2,3-dione Drug Info Ki = 3020 nM [528749]
1,1,1-trifluoro-3-(octylsulfinyl)propan-2-one Drug Info IC50 = 23 nM [529157]
1,1,1-trifluoro-3-(hexylsulfinyl)propan-2-one Drug Info IC50 = 33 nM [529157]
3-(decylthio)-1,1,1-trifluoropropan-2-one Drug Info IC50 = 1.3 nM [529157]
3-(butylthio)-1,1,1-trifluoropropan-2-one Drug Info IC50 = 4.5 nM [529157]
1,2-Bis-(3-methoxy-phenyl)-ethane-1,2-dione Drug Info Ki = 1540 nM [527510]
1,2-Bis-(2-chloro-phenyl)-ethane-1,2-dione Drug Info Ki = 1650 nM [527510]
BENZIL Drug Info IC50 = 830 nM [529157]
3-(decylsulfonyl)-1,1,1-trifluoropropan-2-one Drug Info IC50 = 28 nM [529157]
3-(dodecylsulfinyl)-1,1,1-trifluoropropan-2-one Drug Info IC50 = 8.6 nM [529157]
1,1,1-trifluoro-3-(hexylthio)propan-2-one Drug Info IC50 = 1.8 nM [529157]
1,2-Bis-(3-nitro-phenyl)-ethane-1,2-dione Drug Info Ki = 18100 nM [527510]
Acenanthrene-9,10-dione Drug Info Ki = 1.5 nM [529103]
1-dodecyl-1H-indole-2,3-dione Drug Info Ki = 10 nM [528749]
1,2-bis(2,5-difluorophenyl)ethane-1,2-dione Drug Info Ki = 260 nM [528766]
Diethyl 2,2,2-trifluoro-1-phenylethyl phosphate Drug Info Ki = 3330 nM [530348]
PACTIMIBE Drug Info IC50 = 300 nM [529589]
Dibutyl 2,2,2-trifluoro-1-phenylethyl phosphate Drug Info Ki = 156 nM [530348]
Dimethyl 2,2,2-trifluoro-1-phenylethyl phosphate Drug Info Ki = 6640 nM [530348]
3-(dodecylsulfonyl)-1,1,1-trifluoropropan-2-one Drug Info IC50 = 46 nM [529157]
1,2-bis(2,4-difluorophenyl)-2-hydroxyethanone Drug Info Ki = 480 nM [528766]
1-(4-Nitro-phenyl)-2-phenyl-ethane-1,2-dione Drug Info Ki = 215 nM [527510]
1,10-phenanthroline-5,6-dione Drug Info Ki = 5400 nM [529103]
1-Phenyl-propane-1,2-dione Drug Info Ki = 5270 nM [527510]
4-(2-Oxo-2-phenyl-acetyl)-benzoic acid Drug Info Ki = 524 nM [527510]
4-chloro-7-methyl-1H-indole-2,3-dione Drug Info Ki = 5530 nM [528749]
1-methyl-1H-indole-2,3-dione Drug Info Ki = 5380 nM [528749]
1-hexadecyl-1H-indole-2,3-dione Drug Info Ki = 16 nM [528749]
4,7-dichloro-1H-indole-2,3-dione Drug Info Ki = 590 nM [528749]
1-butyryl-1H-indole-2,3-dione Drug Info Ki = 7690 nM [528749]
7-(trifluoromethyl)-1H-indole-2,3-dione Drug Info Ki = 13100 nM [528749]
1-propionyl-1H-indole-2,3-dione Drug Info Ki = 17500 nM [528749]
1-phenyl-1H-indole-2,3-dione Drug Info Ki = 23 nM [528749]
5-chloro-1H-indole-2,3-dione Drug Info Ki = 1220 nM [528749]
1-Phenyl-2-p-tolyl-ethane-1,2-dione Drug Info Ki = 125 nM [527510]
4-chloro-1H-indole-2,3-dione Drug Info Ki = 8250 nM [528749]
NSC-23180 Drug Info Ki = 15.9 nM [529103]
5-(trifluoromethoxy)-1H-indole-2,3-dione Drug Info Ki = 16500 nM [528749]
1-(2-iodoethyl)-1H-indole-2,3-dione Drug Info Ki = 130 nM [528749]
6-bromo-5-methyl-1H-indole-2,3-dione Drug Info Ki = 16500 nM [528749]
2,2-Dimethoxy-1,2-diphenyl-ethanone Drug Info Ki = 15300 nM [527510]
1-(4-Methoxy-phenyl)-2-phenyl-ethane-1,2-dione Drug Info Ki = 175 nM [527510]
1-(3,4-dichlorobenzyl)-1H-indole-2,3-dione Drug Info Ki = 31 nM [528749]
4,6-dichloro-1H-indole-2,3-dione Drug Info Ki = 890 nM [528749]
6,7-dichloro-1H-indole-2,3-dione Drug Info Ki = 9400 nM [528749]
1,2-Bis-(4-chloro-phenyl)-ethane-1,2-dione Drug Info Ki = 182 nM [527510]
1-(2-bromoethyl)-1H-indole-2,3-dione Drug Info Ki = 290 nM [528749]
1,2-Di-p-tolyl-ethane-1,2-dione Drug Info Ki = 532 nM [527510]
1,2-bis(3,4-difluorophenyl)-2-hydroxyethanone Drug Info Ki = 1300 nM [528766]
1,2-bis(2,3,6-trifluorophenyl)ethane-1,2-dione Drug Info Ki = 320 nM [528766]
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone Drug Info Ki = 170 nM [528766]
7-chloro-1H-indole-2,3-dione Drug Info Ki = 11400 nM [528749]
1,2-bis(2,3-fluorophenyl)ethane-1,2-dione Drug Info Ki = 34.7 nM [528766]
1,1,1-trifluoro-3-(octylthio)propan-2-one Drug Info IC50 = 2.4 nM [529157]
2,2-dimethyl-3-methyleneheptadecane Drug Info IC50 = 5.3 nM [529157]
1,1,1-trifluoro-3-(hexylsulfonyl)propan-2-one Drug Info IC50 = 100 nM [529157]
1,2-Bis-(4-methoxy-phenyl)-ethane-1,2-dione Drug Info Ki = 3410 nM [527510]
1,2-bis(2,3,5-trifluorophenyl)-2-hydroxyethanone Drug Info Ki = 665 nM [528766]
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione Drug Info Ki = 97.2 nM [528766]
1-(4-chlorobenzyl)-1H-indole-2,3-dione Drug Info Ki = 25 nM [528749]
1-(3,4-Dimethyl-phenyl)-2-phenyl-ethane-1,2-dione Drug Info Ki = 99.1 nM [527510]
1,2-bis(3,4,5-trifluorophenyl)-2-hydroxyethanone Drug Info Ki = 1000 nM [528766]
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione Drug Info Ki = 140 nM [528766]
1,2-bis(2,3,4-trifluorophenyl)-2-hydroxyethanone Drug Info Ki = 260 nM [528766]
1-(4-Chloro-phenyl)-2-p-tolyl-ethane-1,2-dione Drug Info Ki = 160 nM [527510]
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione Drug Info Ki = 91.3 nM [528766]
3,5-Di-tert-butyl-[1,2]benzoquinone Drug Info Ki = 88.6 nM [527510]
1,1,1-trifluorododecan-2-one Drug Info IC50 = 9.3 nM [529157]
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone Drug Info Ki = 230 nM [528766]
1,2-bis(3-fluorophenyl)ethane-1,2-dione Drug Info Ki = 100 nM [528766]
3-(decylsulfinyl)-1,1,1-trifluoropropan-2-one Drug Info IC50 = 3.2 nM [529157]
1,2-bis(3,4-difluorophenyl)ethane-1,2-dione Drug Info Ki = 300 nM [528766]
3-(butylsulfinyl)-1,1,1-trifluoropropan-2-one Drug Info IC50 = 270 nM [529157]
1,2-bis(2,6-difluorophenyl)ethane-1,2-dione Drug Info Ki = 5650 nM [528766]
1,2-bis(4-fluorophenyl)ethane-1,2-dione Drug Info Ki = 230 nM [528766]
1,2-bis(2-fluorophenyl)-2-hydroxyethanone Drug Info Ki = 990 nM [528766]
1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione Drug Info Ki = 470 nM [528766]
1-(4-Chloro-phenyl)-2-phenyl-ethane-1,2-dione Drug Info Ki = 47.4 nM [527510]
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone Drug Info Ki = 190 nM [528766]
1,1,1-trifluoro-3-(octylsulfonyl)propan-2-one Drug Info IC50 = 460 nM [529157]
1,2-bis(2-fluorophenyl)ethane-1,2-dione Drug Info Ki = 185 nM [528766]
1,2-bis(2,4-difluorophenyl)ethane-1,2-dione Drug Info Ki = 370 nM [528766]
Heptane-2,3-dione Drug Info Ki = 16900 nM [527510]
PYRIPYROPENE A Drug Info IC50 = 640 nM [527138]
1,2-NAPHTHOQUINONE Drug Info Ki = 930 nM [529103]
1,2-Di-naphthalen-2-yl-ethane-1,2-dione Drug Info Ki = 1.04 nM [527692]
1,2-bis(3-fluorophenyl)-2-hydroxyethanon Drug Info Ki = 3130 nM [528766]
1,2-bis(2,3-difluorophenyl)-2-hydroxyethanone Drug Info Ki = 730 nM [528766]
1,2-dicyclohexylethane-1,2-dione Drug Info Ki = 72 nM [529103]
5,6-dinitroacenaphthoquinone Drug Info Ki = 570 nM [529103]
References
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 527138Bioorg Med Chem Lett. 2004 Aug 16;14(16):4277-80.Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas.
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Ref 529103J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
Ref 529103J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
Ref 529103J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
Ref 529103J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
Ref 529103J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 529103J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 530348Bioorg Med Chem Lett. 2009 Oct 1;19(19):5528-30. Epub 2009 Aug 21.Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics.
Ref 529589J Med Chem. 2008 Aug 14;51(15):4823-33. Epub 2008 Jul 12.Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical propertiesand biological activities by introduction of carboxylic acid.
Ref 530348Bioorg Med Chem Lett. 2009 Oct 1;19(19):5528-30. Epub 2009 Aug 21.Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics.
Ref 530348Bioorg Med Chem Lett. 2009 Oct 1;19(19):5528-30. Epub 2009 Aug 21.Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics.
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 529103J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 529103J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528749J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 529157Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 527510J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.
Ref 527138Bioorg Med Chem Lett. 2004 Aug 16;14(16):4277-80.Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas.
Ref 529103J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
Ref 527692J Med Chem. 2005 Aug 25;48(17):5543-50.Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528766Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 529103J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
Ref 529103J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.

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