Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T76369 | ||||
Target Name | Liver carboxylesterase | ||||
Target Type | Successful |
||||
Drug Potency against Target | BENZOIN | Drug Info | Ki = 7210 nM | [528766] | |
5,7-dichloro-1H-indole-2,3-dione | Drug Info | Ki = 3520 nM | [528749] | ||
(E)-Octadec-9-enoic acid phenylamide | Drug Info | IC50 = 170 nM | [527138] | ||
3,4,5,6-Tetrachloro-[1,2]benzoquinone | Drug Info | Ki = 5440 nM | [527510] | ||
11,12-dihydro-dibenzo[a,e]cyclooctene-5,6-dione | Drug Info | Ki = 2980 nM | [529103] | ||
Thieno[3,2-e][1]benzothiophene-4,5-dione | Drug Info | Ki = 150 nM | [529103] | ||
1,2-indanedione | Drug Info | Ki = 5240 nM | [529103] | ||
Phenanthrene-9,10-dione | Drug Info | Ki = 2.5 nM | [529103] | ||
ACENAPHTHOQUINONE | Drug Info | Ki = 31 nM | [529103] | ||
CHLORANIL | Drug Info | Ki = 83.9 nM | [527510] | ||
1-benzyl-1H-indole-2,3-dione | Drug Info | Ki = 1700 nM | [528749] | ||
4,5-dichloro-1H-indole-2,3-dione | Drug Info | Ki = 3020 nM | [528749] | ||
1,1,1-trifluoro-3-(octylsulfinyl)propan-2-one | Drug Info | IC50 = 23 nM | [529157] | ||
1,1,1-trifluoro-3-(hexylsulfinyl)propan-2-one | Drug Info | IC50 = 33 nM | [529157] | ||
3-(decylthio)-1,1,1-trifluoropropan-2-one | Drug Info | IC50 = 1.3 nM | [529157] | ||
3-(butylthio)-1,1,1-trifluoropropan-2-one | Drug Info | IC50 = 4.5 nM | [529157] | ||
1,2-Bis-(3-methoxy-phenyl)-ethane-1,2-dione | Drug Info | Ki = 1540 nM | [527510] | ||
1,2-Bis-(2-chloro-phenyl)-ethane-1,2-dione | Drug Info | Ki = 1650 nM | [527510] | ||
BENZIL | Drug Info | IC50 = 830 nM | [529157] | ||
3-(decylsulfonyl)-1,1,1-trifluoropropan-2-one | Drug Info | IC50 = 28 nM | [529157] | ||
3-(dodecylsulfinyl)-1,1,1-trifluoropropan-2-one | Drug Info | IC50 = 8.6 nM | [529157] | ||
1,1,1-trifluoro-3-(hexylthio)propan-2-one | Drug Info | IC50 = 1.8 nM | [529157] | ||
1,2-Bis-(3-nitro-phenyl)-ethane-1,2-dione | Drug Info | Ki = 18100 nM | [527510] | ||
Acenanthrene-9,10-dione | Drug Info | Ki = 1.5 nM | [529103] | ||
1-dodecyl-1H-indole-2,3-dione | Drug Info | Ki = 10 nM | [528749] | ||
1,2-bis(2,5-difluorophenyl)ethane-1,2-dione | Drug Info | Ki = 260 nM | [528766] | ||
Diethyl 2,2,2-trifluoro-1-phenylethyl phosphate | Drug Info | Ki = 3330 nM | [530348] | ||
PACTIMIBE | Drug Info | IC50 = 300 nM | [529589] | ||
Dibutyl 2,2,2-trifluoro-1-phenylethyl phosphate | Drug Info | Ki = 156 nM | [530348] | ||
Dimethyl 2,2,2-trifluoro-1-phenylethyl phosphate | Drug Info | Ki = 6640 nM | [530348] | ||
3-(dodecylsulfonyl)-1,1,1-trifluoropropan-2-one | Drug Info | IC50 = 46 nM | [529157] | ||
1,2-bis(2,4-difluorophenyl)-2-hydroxyethanone | Drug Info | Ki = 480 nM | [528766] | ||
1-(4-Nitro-phenyl)-2-phenyl-ethane-1,2-dione | Drug Info | Ki = 215 nM | [527510] | ||
1,10-phenanthroline-5,6-dione | Drug Info | Ki = 5400 nM | [529103] | ||
1-Phenyl-propane-1,2-dione | Drug Info | Ki = 5270 nM | [527510] | ||
4-(2-Oxo-2-phenyl-acetyl)-benzoic acid | Drug Info | Ki = 524 nM | [527510] | ||
4-chloro-7-methyl-1H-indole-2,3-dione | Drug Info | Ki = 5530 nM | [528749] | ||
1-methyl-1H-indole-2,3-dione | Drug Info | Ki = 5380 nM | [528749] | ||
1-hexadecyl-1H-indole-2,3-dione | Drug Info | Ki = 16 nM | [528749] | ||
4,7-dichloro-1H-indole-2,3-dione | Drug Info | Ki = 590 nM | [528749] | ||
1-butyryl-1H-indole-2,3-dione | Drug Info | Ki = 7690 nM | [528749] | ||
7-(trifluoromethyl)-1H-indole-2,3-dione | Drug Info | Ki = 13100 nM | [528749] | ||
1-propionyl-1H-indole-2,3-dione | Drug Info | Ki = 17500 nM | [528749] | ||
1-phenyl-1H-indole-2,3-dione | Drug Info | Ki = 23 nM | [528749] | ||
5-chloro-1H-indole-2,3-dione | Drug Info | Ki = 1220 nM | [528749] | ||
1-Phenyl-2-p-tolyl-ethane-1,2-dione | Drug Info | Ki = 125 nM | [527510] | ||
4-chloro-1H-indole-2,3-dione | Drug Info | Ki = 8250 nM | [528749] | ||
NSC-23180 | Drug Info | Ki = 15.9 nM | [529103] | ||
5-(trifluoromethoxy)-1H-indole-2,3-dione | Drug Info | Ki = 16500 nM | [528749] | ||
1-(2-iodoethyl)-1H-indole-2,3-dione | Drug Info | Ki = 130 nM | [528749] | ||
6-bromo-5-methyl-1H-indole-2,3-dione | Drug Info | Ki = 16500 nM | [528749] | ||
2,2-Dimethoxy-1,2-diphenyl-ethanone | Drug Info | Ki = 15300 nM | [527510] | ||
1-(4-Methoxy-phenyl)-2-phenyl-ethane-1,2-dione | Drug Info | Ki = 175 nM | [527510] | ||
1-(3,4-dichlorobenzyl)-1H-indole-2,3-dione | Drug Info | Ki = 31 nM | [528749] | ||
4,6-dichloro-1H-indole-2,3-dione | Drug Info | Ki = 890 nM | [528749] | ||
6,7-dichloro-1H-indole-2,3-dione | Drug Info | Ki = 9400 nM | [528749] | ||
1,2-Bis-(4-chloro-phenyl)-ethane-1,2-dione | Drug Info | Ki = 182 nM | [527510] | ||
1-(2-bromoethyl)-1H-indole-2,3-dione | Drug Info | Ki = 290 nM | [528749] | ||
1,2-Di-p-tolyl-ethane-1,2-dione | Drug Info | Ki = 532 nM | [527510] | ||
1,2-bis(3,4-difluorophenyl)-2-hydroxyethanone | Drug Info | Ki = 1300 nM | [528766] | ||
1,2-bis(2,3,6-trifluorophenyl)ethane-1,2-dione | Drug Info | Ki = 320 nM | [528766] | ||
1,2-bis(3,5-difluorophenyl)-2-hydroxyethanone | Drug Info | Ki = 170 nM | [528766] | ||
7-chloro-1H-indole-2,3-dione | Drug Info | Ki = 11400 nM | [528749] | ||
1,2-bis(2,3-fluorophenyl)ethane-1,2-dione | Drug Info | Ki = 34.7 nM | [528766] | ||
1,1,1-trifluoro-3-(octylthio)propan-2-one | Drug Info | IC50 = 2.4 nM | [529157] | ||
2,2-dimethyl-3-methyleneheptadecane | Drug Info | IC50 = 5.3 nM | [529157] | ||
1,1,1-trifluoro-3-(hexylsulfonyl)propan-2-one | Drug Info | IC50 = 100 nM | [529157] | ||
1,2-Bis-(4-methoxy-phenyl)-ethane-1,2-dione | Drug Info | Ki = 3410 nM | [527510] | ||
1,2-bis(2,3,5-trifluorophenyl)-2-hydroxyethanone | Drug Info | Ki = 665 nM | [528766] | ||
1,2-bis(3,5-difluorophenyl)ethane-1,2-dione | Drug Info | Ki = 97.2 nM | [528766] | ||
1-(4-chlorobenzyl)-1H-indole-2,3-dione | Drug Info | Ki = 25 nM | [528749] | ||
1-(3,4-Dimethyl-phenyl)-2-phenyl-ethane-1,2-dione | Drug Info | Ki = 99.1 nM | [527510] | ||
1,2-bis(3,4,5-trifluorophenyl)-2-hydroxyethanone | Drug Info | Ki = 1000 nM | [528766] | ||
1,2-bis(2,3,5-trifluorophenyl)ethane-1,2-dione | Drug Info | Ki = 140 nM | [528766] | ||
1,2-bis(2,3,4-trifluorophenyl)-2-hydroxyethanone | Drug Info | Ki = 260 nM | [528766] | ||
1-(4-Chloro-phenyl)-2-p-tolyl-ethane-1,2-dione | Drug Info | Ki = 160 nM | [527510] | ||
1,2-bis(2,3,4-trifluorophenyl)ethane-1,2-dione | Drug Info | Ki = 91.3 nM | [528766] | ||
3,5-Di-tert-butyl-[1,2]benzoquinone | Drug Info | Ki = 88.6 nM | [527510] | ||
1,1,1-trifluorododecan-2-one | Drug Info | IC50 = 9.3 nM | [529157] | ||
1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone | Drug Info | Ki = 230 nM | [528766] | ||
1,2-bis(3-fluorophenyl)ethane-1,2-dione | Drug Info | Ki = 100 nM | [528766] | ||
3-(decylsulfinyl)-1,1,1-trifluoropropan-2-one | Drug Info | IC50 = 3.2 nM | [529157] | ||
1,2-bis(3,4-difluorophenyl)ethane-1,2-dione | Drug Info | Ki = 300 nM | [528766] | ||
3-(butylsulfinyl)-1,1,1-trifluoropropan-2-one | Drug Info | IC50 = 270 nM | [529157] | ||
1,2-bis(2,6-difluorophenyl)ethane-1,2-dione | Drug Info | Ki = 5650 nM | [528766] | ||
1,2-bis(4-fluorophenyl)ethane-1,2-dione | Drug Info | Ki = 230 nM | [528766] | ||
1,2-bis(2-fluorophenyl)-2-hydroxyethanone | Drug Info | Ki = 990 nM | [528766] | ||
1,2-bis(3,4,5-trifluorophenyl)ethane-1,2-dione | Drug Info | Ki = 470 nM | [528766] | ||
1-(4-Chloro-phenyl)-2-phenyl-ethane-1,2-dione | Drug Info | Ki = 47.4 nM | [527510] | ||
1,2-bis(2,6-difluorophenyl)-2-hydroxyethanone | Drug Info | Ki = 190 nM | [528766] | ||
1,1,1-trifluoro-3-(octylsulfonyl)propan-2-one | Drug Info | IC50 = 460 nM | [529157] | ||
1,2-bis(2-fluorophenyl)ethane-1,2-dione | Drug Info | Ki = 185 nM | [528766] | ||
1,2-bis(2,4-difluorophenyl)ethane-1,2-dione | Drug Info | Ki = 370 nM | [528766] | ||
Heptane-2,3-dione | Drug Info | Ki = 16900 nM | [527510] | ||
PYRIPYROPENE A | Drug Info | IC50 = 640 nM | [527138] | ||
1,2-NAPHTHOQUINONE | Drug Info | Ki = 930 nM | [529103] | ||
1,2-Di-naphthalen-2-yl-ethane-1,2-dione | Drug Info | Ki = 1.04 nM | [527692] | ||
1,2-bis(3-fluorophenyl)-2-hydroxyethanon | Drug Info | Ki = 3130 nM | [528766] | ||
1,2-bis(2,3-difluorophenyl)-2-hydroxyethanone | Drug Info | Ki = 730 nM | [528766] | ||
1,2-dicyclohexylethane-1,2-dione | Drug Info | Ki = 72 nM | [529103] | ||
5,6-dinitroacenaphthoquinone | Drug Info | Ki = 570 nM | [529103] | ||
References | |||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 527138 | Bioorg Med Chem Lett. 2004 Aug 16;14(16):4277-80.Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 529103 | J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. | ||||
Ref 529103 | J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. | ||||
Ref 529103 | J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. | ||||
Ref 529103 | J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. | ||||
Ref 529103 | J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 529103 | J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 530348 | Bioorg Med Chem Lett. 2009 Oct 1;19(19):5528-30. Epub 2009 Aug 21.Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics. | ||||
Ref 529589 | J Med Chem. 2008 Aug 14;51(15):4823-33. Epub 2008 Jul 12.Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical propertiesand biological activities by introduction of carboxylic acid. | ||||
Ref 530348 | Bioorg Med Chem Lett. 2009 Oct 1;19(19):5528-30. Epub 2009 Aug 21.Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics. | ||||
Ref 530348 | Bioorg Med Chem Lett. 2009 Oct 1;19(19):5528-30. Epub 2009 Aug 21.Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics. | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 529103 | J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 529103 | J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 529157 | Bioorg Med Chem. 2008 Feb 15;16(4):2114-30. Epub 2007 Nov 26.Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 527510 | J Med Chem. 2005 Apr 21;48(8):2906-15.Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases. | ||||
Ref 527138 | Bioorg Med Chem Lett. 2004 Aug 16;14(16):4277-80.Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas. | ||||
Ref 529103 | J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. | ||||
Ref 527692 | J Med Chem. 2005 Aug 25;48(17):5543-50.Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 528766 | Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils. | ||||
Ref 529103 | J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. | ||||
Ref 529103 | J Med Chem. 2007 Nov 15;50(23):5727-34. Epub 2007 Oct 17.Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. |
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