Drug General Information
Drug ID	D0XP0J
Former ID	DNC014114
Drug Name	Dimethyl 2,2,2-trifluoro-1-phenylethyl phosphate
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530348]
Structure		Download 2D MOL 3D MOL
Formula	C10H12F3O4P
Canonical SMILES	COP(=O)(OC)OC(C1=CC=CC=C1)C(F)(F)F
InChI	1S/C10H12F3O4P/c1-15-18(14,16-2)17-9(10(11,12)13)8-6-4-3-5-7-8/h3-7,9H,1-2H3
InChIKey	LEDQZLXLDMICCN-UHFFFAOYSA-N
PubChem Compound ID	11666354
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Inhibitor	[530348]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 530348	Bioorg Med Chem Lett. 2009 Oct 1;19(19):5528-30. Epub 2009 Aug 21.Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics.
Ref 530348	Bioorg Med Chem Lett. 2009 Oct 1;19(19):5528-30. Epub 2009 Aug 21.Synthesis of organophosphates with fluorine-containing leaving groups as serine esterase inhibitors with potential for Alzheimer disease therapeutics.

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