Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T61317
|
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| Former ID |
TTDR00657
|
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| Target Name |
3-oxoacyl-[acyl-carrier protein] reductase
|
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| Gene Name |
fabG
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| Synonyms |
3-ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase (FabG); fabG
|
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| Target Type |
Research
|
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| BioChemical Class |
Short-chain dehydrogenases reductases
|
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| Target Validation |
T61317
|
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| UniProt ID | |||||
| EC Number |
EC 1.1.1.100
|
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| Sequence |
MSVLHRFYLFFLFTKFFHCYKISYVLKNAKLAPNHAIKNINSLNLLSENKKENYYYCGEN
KVALVTGAGRGIGREIAKMLAKSVSHVICISRTQKSCDSVVDEIKSFGYESSGYAGDVSK KEEISEVINKILTEHKNVDILVSNAGITRDNLFLRMKNDEWEDVLRTNLNSLFYITQPIS KRMINNRYGRIINISSIVGLTGNVGQANYSSSKAGVIGFTKSLAKELASRNITVNAIAPG FISSDMTDKISEQIKKNIISNIPAGRMGTPEEVANLACFLSSDKSGYINGRVFVIDGGLS P |
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| Inhibitor | (-)-CATECHINGALLATE | Drug Info | [1] | ||
| 2-Hexadecynoic acid | Drug Info | [2] | |||
| CHRYSIN | Drug Info | [1] | |||
| EPIGALOCATECHIN GALLATE | Drug Info | [1] | |||
| FISETIN | Drug Info | [1] | |||
| GALLOCATECHIN GALLATE | Drug Info | [1] | |||
| ISORHAMNETIN | Drug Info | [1] | |||
| KAEMPFEROL | Drug Info | [1] | |||
| MORIN | Drug Info | [1] | |||
| Cofactor | NADPH | Drug Info | [3] | ||
| References | |||||
| REF 1 | J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. | ||||
| REF 2 | Bioorg Med Chem. 2010 Nov 1;18(21):7475-85. Epub 2010 Sep 18.2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. | ||||
| REF 3 | Functional characterization of beta-ketoacyl-ACP reductase (FabG) from Plasmodium falciparum. Biochem Biophys Res Commun. 2003 Mar 28;303(1):387-92. | ||||
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