| Drug General Information |
| Drug ID |
D0G3TK
|
| Former ID |
DNC006613
|
| Drug Name |
KAEMPFEROL
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C15H10O6
|
| Canonical SMILES |
C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O
|
| InChI |
1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
|
| InChIKey |
IYRMWMYZSQPJKC-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Neuraminidase |
Target Info |
Inhibitor |
[2]
|
|---|
| mRNA of human 5-lipoxygenase |
Target Info |
Inhibitor |
[1]
|
| Arachidonate 15-lipoxygenase |
Target Info |
Inhibitor |
[1]
|
| Aldose reductase |
Target Info |
Inhibitor |
[3]
|
| Lactoylglutathione lyase |
Target Info |
Inhibitor |
[4]
|
| 3-oxoacyl-[acyl-carrier protein] reductase |
Target Info |
Inhibitor |
[5]
|
| Cytochrome P450 1B1 |
Target Info |
Inhibitor |
[6]
|
| Estradiol 17 beta-dehydrogenase 1 |
Target Info |
Inhibitor |
[7]
|
| mRNA of androgen receptor |
Target Info |
Inhibitor |
[8]
|
|
BioCyc Pathway
|
Aspirin-triggered lipoxin biosynthesis
|
|
Resolvin D biosynthesis
|
|
Leukotriene biosynthesis
|
|
Lipoxin biosynthesis
|
|
Aspirin triggered resolvin D biosynthesis
|
|
Aspirin triggered resolvin E biosynthesisPWY66-397:Resolvin D biosynthesis
|
|
Lipoxin biosynthesisPWY-5453:Methylglyoxal degradation III
|
|
Acetone degradation I (to methylglyoxal)PWY-5386:Methylglyoxal degradation IPWY66-401:Superpathway of tryptophan utilization
|
|
Superpathway of melatonin degradation
|
|
Melatonin degradation IPWY-7305:Superpathway of steroid hormone biosynthesis
|
|
Estradiol biosynthesis I
|
|
KEGG Pathway
|
Other glycan degradationhsa00590:Arachidonic acid metabolism
|
|
Metabolic pathways
|
|
Serotonergic synapse
|
|
Ovarian steroidogenesis
|
|
Toxoplasmosishsa00590:Arachidonic acid metabolism
|
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Linoleic acid metabolism
|
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Serotonergic synapsehsa00040:Pentose and glucuronate interconversions
|
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Fructose and mannose metabolism
|
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Galactose metabolism
|
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Glycerolipid metabolism
|
|
Metabolic pathwayshsa00620:Pyruvate metabolismhsa00140:Steroid hormone biosynthesis
|
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Tryptophan metabolism
|
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Metabolism of xenobiotics by cytochrome P450
|
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Chemical carcinogenesis
|
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MicroRNAs in cancerhsa00140:Steroid hormone biosynthesis
|
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Ovarian steroidogenesishsa04114:Oocyte meiosis
|
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Pathways in cancer
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Prostate cancer
|
|
NetPath Pathway
|
IL4 Signaling PathwayNetPath_16:IL4 Signaling PathwayNetPath_13:IL1 Signaling Pathway
|
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TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_23:TSH Signaling Pathway
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IL4 Signaling Pathway
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TGF_beta_Receptor Signaling PathwayNetPath_25:FSH Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
|
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AndrogenReceptor Signaling Pathway
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FSH Signaling Pathway
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PANTHER Pathway
|
Inflammation mediated by chemokine and cytokine signaling pathwayP02727:Androgen/estrogene/progesterone biosynthesis
|
|
Pathway Interaction Database
|
IL4-mediated signaling eventssmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
|
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Coregulation of Androgen receptor activity
|
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Regulation of Androgen receptor activity
|
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Nongenotropic Androgen signaling
|
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Regulation of nuclear beta catenin signaling and target gene transcription
|
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FOXA1 transcription factor network
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Notch-mediated HES/HEY network
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PathWhiz Pathway
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Arachidonic Acid MetabolismPW000044:Arachidonic Acid MetabolismPW000025:Fructose and Mannose Degradation
|
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Pyruvate Metabolism
|
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Pterine Biosynthesis
|
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Glycerolipid Metabolism
|
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Galactose MetabolismPW000034:Pyruvaldehyde Degradation
|
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Pyruvate MetabolismPW000045:Androgen and Estrogen Metabolism
|
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Reactome
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Pyruvate metabolismR-HSA-211976:Endogenous sterolsR-HSA-2453902:The canonical retinoid cycle in rods (twilight vision)R-HSA-383280:Nuclear Receptor transcription pathway
|
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Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
|
|
WikiPathways
|
Arachidonic acid metabolism
|
|
Eicosanoid Synthesis
|
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Selenium Micronutrient NetworkWP2650:Arachidonic acid metabolism
|
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Eicosanoid SynthesisWP702:Metapathway biotransformation
|
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Polyol Pathway
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Metabolism of steroid hormones and vitamin DWP702:Metapathway biotransformation
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Estrogen metabolism
|
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Benzo(a)pyrene metabolism
|
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Tamoxifen metabolism
|
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Tryptophan metabolism
|
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Oxidation by Cytochrome P450
|
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Nuclear Receptors Meta-Pathway
|
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Estrogen Receptor Pathway
|
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Sulindac Metabolic Pathway
|
|
Arylhydrocarbon receptor (AhR) signaling pathway
|
|
miR-targeted genes in muscle cell - TarBase
|
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miR-targeted genes in lymphocytes - TarBase
|
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miR-targeted genes in epithelium - TarBase
|
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miR-targeted genes in adipocytes - TarBase
|
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Phase 1 - Functionalization of compoundsWP496:Steroid Biosynthesis
|
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Metabolism of steroid hormones and vitamin D
|
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Prostate CancerWP706:SIDS Susceptibility Pathways
|
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Integrated Pancreatic Cancer Pathway
|
|
Prostate Cancer
|
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Integrated Breast Cancer Pathway
|
|
Nuclear Receptors
|
|
Androgen receptor signaling pathway
|
| References |
| REF 1 | J Nat Prod. 2007 May;70(5):859-62. Epub 2007 Mar 23.Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. |
|---|
| REF 2 | Bioorg Med Chem. 2009 Oct 1;17(19):6816-23. Epub 2009 Aug 21.Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. |
|---|
| REF 3 | J Nat Prod. 2008 Apr;71(4):713-5. Epub 2008 Feb 26.Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activity. |
|---|
| REF 4 | Bioorg Med Chem. 2008 Apr 1;16(7):3969-75. Epub 2008 Jan 24.Structure-activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects. |
|---|
| REF 5 | J Med Chem. 2006 Jun 1;49(11):3345-53.Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. |
|---|
| REF 6 | Bioorg Med Chem. 2010 Sep 1;18(17):6310-5. Epub 2010 Jul 13.Selective inhibition of methoxyflavonoids on human CYP1B1 activity. |
|---|
| REF 7 | J Med Chem. 2008 Jul 24;51(14):4188-99. Epub 2008 Jun 6.Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries. |
|---|
| REF 8 | Bioorg Med Chem Lett. 2009 Aug 15;19(16):4706-10. Epub 2009 Jun 23.Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay. |
|---|
