Target Information

Target General Infomation
Target ID
T12409
Former ID
TTDR00753
Target Name
Glucosamine-6-phosphate synthase
Gene Name
glmS
Synonyms
D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine--fructose-6-phosphate aminotransferase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase; glmS
Target Type
Clinical Trial
Function
Catalyzesthe first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
BioChemical Class
Transferases of nitrogenous groups
UniProt ID
P17169
EC Number
EC 2.6.1.16
Sequence
MCGIVGAIAQRDVAEILLEGLRRLEYRGYDSAGLAVVDAEGHMTRLRRLGKVQMLAQAAE
EHPLHGGTGIAHTRWATHGEPSEVNAHPHVSEHIVVVHNGIIENHEPLREELKARGYTFV
SETDTEVIAHLVNWELKQGGTLREAVLRAIPQLRGAYGTVIMDSRHPDTLLAARSGSPLV
IGLGMGENFIASDQLALLPVTRRFIFLEEGDIAEITRRSVNIFDKTGAEVKRQDIESNLQ
YDAGDKGIYRHYMQKEIYEQPNAIKNTLTGRISHGQVDLSELGPNADELLSKVEHIQILA
CGTSYNSGMVSRYWFESLAGIPCDVEIASEFRYRKSAVRRNSLMITLSQSGETADTLAGL
RLSKELGYLGSLAICNVPGSSLVRESDLALMTNAGTEIGVASTKAFTTQLTVLLMLVAKL
SRLKGLDASIEHDIVHGLQALPSRIEQMLSQDKRIEALAEDFSDKHHALFLGRGDQYPIA
LEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRAR
GGQLYVFADQDAGFVSSDNMHIIEMPHVEEVIAPIFYTVPLQLLAYHVALIKGTDVDQPR
NLAKSVTVE
Drugs and Mode of Action
Drug(s) Glucose-6-Phosphate Drug Info Phase 1 Discovery agent [467886], [523177]
Inhibitor 2-(N-Morpholino)-Ethanesulfonic Acid Drug Info [551393]
2-Deoxy-2-Amino Glucitol-6-Phosphate Drug Info [551393]
2-Methyl-2,4-Pentanediol Drug Info [551393]
Acetate Ion Drug Info [551393]
Alpha-D-Glucose-6-Phosphate Drug Info [551393]
Glucosamine 6-Phosphate Drug Info [551393]
Glucose-6-Phosphate Drug Info [551393]
Glutamine Hydroxamate Drug Info [551393]
References
Ref 467886(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4647).
Ref 523177ClinicalTrials.gov (NCT01205178) G6PD (Glucose-6-phosphate Dehydrogenase) Study to Evaluate Hemolysis Potential of TFQ (Tafenoquine). U.S. National Institutes of Health.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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