Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T12409
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| Former ID |
TTDR00753
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| Target Name |
Glucosamine-6-phosphate synthase
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| Gene Name |
glmS
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| Synonyms |
D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine--fructose-6-phosphate aminotransferase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase; glmS
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| Target Type |
Clinical Trial
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| Function |
Catalyzesthe first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
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| BioChemical Class |
Transferases of nitrogenous groups
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| UniProt ID | |||||
| EC Number |
EC 2.6.1.16
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| Sequence |
MCGIVGAIAQRDVAEILLEGLRRLEYRGYDSAGLAVVDAEGHMTRLRRLGKVQMLAQAAE
EHPLHGGTGIAHTRWATHGEPSEVNAHPHVSEHIVVVHNGIIENHEPLREELKARGYTFV SETDTEVIAHLVNWELKQGGTLREAVLRAIPQLRGAYGTVIMDSRHPDTLLAARSGSPLV IGLGMGENFIASDQLALLPVTRRFIFLEEGDIAEITRRSVNIFDKTGAEVKRQDIESNLQ YDAGDKGIYRHYMQKEIYEQPNAIKNTLTGRISHGQVDLSELGPNADELLSKVEHIQILA CGTSYNSGMVSRYWFESLAGIPCDVEIASEFRYRKSAVRRNSLMITLSQSGETADTLAGL RLSKELGYLGSLAICNVPGSSLVRESDLALMTNAGTEIGVASTKAFTTQLTVLLMLVAKL SRLKGLDASIEHDIVHGLQALPSRIEQMLSQDKRIEALAEDFSDKHHALFLGRGDQYPIA LEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNNELLEKLKSNIEEVRAR GGQLYVFADQDAGFVSSDNMHIIEMPHVEEVIAPIFYTVPLQLLAYHVALIKGTDVDQPR NLAKSVTVE |
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| Drugs and Mode of Action | |||||
| Drug(s) | Glucose-6-Phosphate | Drug Info | Phase 1 | Discovery agent | [1], [2] |
| Inhibitor | 2-(N-Morpholino)-Ethanesulfonic Acid | Drug Info | [3] | ||
| 2-Deoxy-2-Amino Glucitol-6-Phosphate | Drug Info | [3] | |||
| 2-Methyl-2,4-Pentanediol | Drug Info | [3] | |||
| Acetate Ion | Drug Info | [3] | |||
| Alpha-D-Glucose-6-Phosphate | Drug Info | [3] | |||
| Glucosamine 6-Phosphate | Drug Info | [3] | |||
| Glucose-6-Phosphate | Drug Info | [3] | |||
| Glutamine Hydroxamate | Drug Info | [3] | |||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4647). | ||||
| REF 2 | ClinicalTrials.gov (NCT01205178) G6PD (Glucose-6-phosphate Dehydrogenase) Study to Evaluate Hemolysis Potential of TFQ (Tafenoquine). U.S. National Institutes of Health. | ||||
| REF 3 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
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