| Drug General Information |
| Drug ID |
D06GOK
|
| Former ID |
DNC002435
|
| Drug Name |
2-Methyl-2,4-Pentanediol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C6H14O2
|
| Canonical SMILES |
CC(CC(C)(C)O)O
|
| InChI |
1S/C6H14O2/c1-5(7)4-6(2,3)8/h5,7-8H,4H2,1-3H3
|
| InChIKey |
SVTBMSDMJJWYQN-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
73810, 3135255, 4543661, 8009776, 8015972, 8155418, 10503462, 11538211, 15218863, 17422143, 24277131, 24771212, 24885762, 24885763, 24897349, 26708091, 37913605, 47206309, 48415077, 48417164, 50002664, 57324554, 57652149, 76593208, 85087780, 87572449, 91689004, 92712798, 103845194, 104225828, 104316221, 117396689, 118309710, 121362183, 124955365, 125565292, 126522935, 126625290, 126676615, 129295655, 134374657, 134972423, 135829545, 137024725, 142332774, 143435347, 143801259, 144209173, 144213135, 152040878
|
| Target and Pathway |
| Target(s) |
Placenta growth factor |
Target Info |
Inhibitor |
[1]
|
|---|
| Glucosamine-6-phosphate synthase |
Target Info |
Inhibitor |
[1]
|
| Phosphopantetheine adenylyltransferase |
Target Info |
Inhibitor |
[1]
|
| mRNA of Protein tyrosine phosphatase-1B |
Target Info |
Inhibitor |
[1]
|
| P-selectin |
Target Info |
Inhibitor |
[1]
|
| CTP synthase |
Target Info |
Inhibitor |
[1]
|
| Nitric-oxide synthase, endothelial |
Target Info |
Inhibitor |
[1]
|
| Presynaptic density protein 95 |
Target Info |
Inhibitor |
[1]
|
| Heat shock protein HSP 90 |
Target Info |
Inhibitor |
[1]
|
| Calmodulin |
Target Info |
Inhibitor |
[1]
|
| Aldo-keto reductase family 1 member C3 |
Target Info |
Inhibitor |
[1]
|
| Phospholipase A2 |
Target Info |
Inhibitor |
[1]
|
| Beta-lactamase |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Citrulline-nitric oxide cyclePWY-7305:Superpathway of steroid hormone biosynthesis
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Allopregnanolone biosynthesis
|
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Androgen biosynthesisLIPASYN-PWY:Phospholipases
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|
KEGG Pathway
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Ras signaling pathway
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|
Rap1 signaling pathway
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PI3K-Akt signaling pathway
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Focal adhesion
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Pathways in cancerhsa00770:Pantothenate and CoA biosynthesis
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Metabolic pathwayshsa04520:Adherens junction
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Insulin signaling pathwayhsa04514:Cell adhesion molecules (CAMs)
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Malaria
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Staphylococcus aureus infectionhsa00240:Pyrimidine metabolism
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Metabolic pathwayshsa00330:Arginine and proline metabolism
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Metabolic pathways
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Calcium signaling pathway
|
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cGMP-PKG signaling pathway
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HIF-1 signaling pathway
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Sphingolipid signaling pathway
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VEGF signaling pathway
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Platelet activation
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Estrogen signaling pathway
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Oxytocin signaling pathwayhsa04390:Hippo signaling pathway
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Glutamatergic synapse
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Huntington's disease
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Cocaine addictionhsa04141:Protein processing in endoplasmic reticulum
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Antigen processing and presentation
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NOD-like receptor signaling pathway
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Progesterone-mediated oocyte maturation
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Pathways in cancer
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Prostate cancerhsa04014:Ras signaling pathway
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cAMP signaling pathway
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Phosphatidylinositol signaling system
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Oocyte meiosis
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Adrenergic signaling in cardiomyocytes
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Vascular smooth muscle contraction
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Circadian entrainment
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Long-term potentiation
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Neurotrophin signaling pathway
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Dopaminergic synapse
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Olfactory transduction
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Phototransduction
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Inflammatory mediator regulation of TRP channels
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Insulin signaling pathway
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GnRH signaling pathway
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Melanogenesis
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Oxytocin signaling pathway
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Glucagon signaling pathway
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Salivary secretion
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Gastric acid secretion
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Alzheimer's disease
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Amphetamine addiction
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Alcoholism
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Pertussis
|
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Tuberculosis
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Gliomahsa00140:Steroid hormone biosynthesis
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Arachidonic acid metabolism
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Ovarian steroidogenesishsa00564:Glycerophospholipid metabolism
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Ether lipid metabolism
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Linoleic acid metabolism
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alpha-Linolenic acid metabolism
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Pancreatic secretion
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Fat digestion and absorption
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NetPath Pathway
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TSH Signaling PathwayNetPath_25:FSH Signaling PathwayNetPath_8:Wnt Signaling PathwayNetPath_14:IL2 Signaling Pathway
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TCR Signaling PathwayNetPath_21:RANKL Signaling Pathway
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TSH Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
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PANTHER Pathway
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Cadherin signaling pathwayP02740:De novo pyrimidine ribonucleotides biosythesisP00005:Angiogenesis
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Endothelin signaling pathway
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Interleukin signaling pathway
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PI3 kinase pathway
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VEGF signaling pathwayP00029:Huntington diseaseP06959:CCKR signaling map ST
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Pathway Interaction Database
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VEGFR1 specific signalsinsulin_pathway:Insulin Pathway
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Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
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Signaling events mediated by PTP1B
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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Signaling events mediated by TCPTP
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IGF1 pathway
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EGF receptor (ErbB1) signaling pathway
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Posttranslational regulation of adherens junction stability and dissassembly
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PDGFR-beta signaling pathway
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N-cadherin signaling eventsil4_2pathway:IL4-mediated signaling events
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amb2 Integrin signalinger_nongenomic_pathway:Plasma membrane estrogen receptor signaling
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Validated transcriptional targets of AP1 family members Fra1 and Fra2
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Angiopoietin receptor Tie2-mediated signaling
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Thromboxane A2 receptor signaling
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SHP2 signaling
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VEGFR1 specific signals
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Signaling events mediated by VEGFR1 and VEGFR2
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PAR1-mediated thrombin signaling eventserbb4_pathway:ErbB4 signaling eventshdac_classii_pathway:Signaling events mediated by HDAC Class II
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Validated targets of C-MYC transcriptional activation
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Integrin-linked kinase signaling
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LKB1 signaling events
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Regulation of Telomerase
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Glucocorticoid receptor regulatory network
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Class I PI3K signaling events
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IL2 signaling events mediated by PI3K
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Regulation of Androgen receptor activity
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Integrins in angiogenesis
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Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
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ErbB receptor signaling network
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Class I PI3K signaling events mediated by Aktbcr_5pathway:BCR signaling pathway
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p38 MAPK signaling pathway
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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IFN-gamma pathway
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Lissencephaly gene (LIS1) in neuronal migration and development
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ErbB1 downstream signaling
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Regulation of cytoplasmic and nuclear SMAD2/3 signaling
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Calcium signaling in the CD4+ TCR pathway
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Insulin-mediated glucose transport
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N-cadherin signaling events
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Cellular roles of Anthrax toxin
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Regulation of Ras family activation
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Downstream signaling in naï
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Fc-epsilon receptor I signaling in mast cells
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PathWhiz Pathway
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Pyrimidine MetabolismPW000564:Muscle/Heart ContractionPW000044:Arachidonic Acid Metabolism
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Reactome
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VEGF ligand-receptor interactions
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VEGF binds to VEGFR leading to receptor dimerizationR-HSA-354192:Integrin alphaIIb beta3 signaling
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Regulation of IFNG signaling
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Regulation of IFNA signaling
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Growth hormone receptor signalingR-HSA-114608:Platelet degranulation
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Cell surface interactions at the vascular wallR-HSA-1222556:ROS production in response to bacteria
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Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
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eNOS activation
|
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Nitric oxide stimulates guanylate cyclase
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VEGFR2 mediated vascular permeabilityR-HSA-399719:Trafficking of AMPA receptors
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Unblocking of NMDA receptor, glutamate binding and activation
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CREB phosphorylation through the activation of CaMKII
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Ras activation uopn Ca2+ infux through NMDA receptor
|
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RHO GTPases activate CIT
|
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RAF/MAP kinase cascadeR-HSA-1236382:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
|
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Regulation of actin dynamics for phagocytic cup formation
|
|
Regulation of PLK1 Activity at G2/M Transition
|
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Attenuation phase
|
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HSF1-dependent transactivation
|
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Loss of Nlp from mitotic centrosomes
|
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Recruitment of mitotic centrosome proteins and complexes
|
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Loss of proteins required for interphase microtubule organization?from the centrosome
|
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EPHA-mediated growth cone collapse
|
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VEGFA-VEGFR2 Pathway
|
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VEGFR2 mediated vascular permeability
|
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Anchoring of the basal body to the plasma membrane
|
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Constitutive Signaling by EGFRvIIIR-HSA-111933:Calmodulin induced events
|
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Platelet degranulation
|
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Translocation of GLUT4 to the plasma membrane
|
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DARPP-32 events
|
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Inactivation, recovery and regulation of the phototransduction cascade
|
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FCERI mediated Ca+2 mobilization
|
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Ca2+ pathway
|
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Smooth Muscle Contraction
|
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VEGFR2 mediated cell proliferation
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RHO GTPases activate IQGAPs
|
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RAF/MAP kinase cascade
|
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Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-975634:Retinoid metabolism and transportR-HSA-1482788:Acyl chain remodelling of PC
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Acyl chain remodelling of PE
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Acyl chain remodelling of PI
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WikiPathways
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Focal Adhesion
|
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Signaling by VEGFWP1857:Metabolism of water-soluble vitamins and cofactorsWP481:Insulin Signaling
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Growth hormone receptor signaling
|
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Leptin signaling pathway
|
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Interferon gamma signaling
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Interferon alpha/beta signaling
|
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Integrin alphaIIb beta3 signalingWP2806:Human Complement System
|
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Spinal Cord Injury
|
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Cell surface interactions at the vascular wallWP1851:Metabolism of nucleotidesWP554:ACE Inhibitor Pathway
|
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EGF/EGFR Signaling Pathway
|
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Myometrial Relaxation and Contraction Pathways
|
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JAK/STAT
|
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Corticotropin-releasing hormone
|
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AGE/RAGE pathway
|
|
Endothelin Pathways
|
|
Effects of Nitric Oxide
|
|
Metabolism of nitric oxide
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AngiogenesisWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
L1CAM interactionsWP2884:NRF2 pathway
|
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Nuclear Receptors Meta-Pathway
|
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Aryl Hydrocarbon Receptor Pathway
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Binding and Uptake of Ligands by Scavenger Receptors
|
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Signaling by ERBB2
|
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Fcgamma receptor (FCGR) dependent phagocytosis
|
|
Influenza Life Cycle
|
|
EBV LMP1 signaling
|
|
Aryl Hydrocarbon Receptor
|
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TNF alpha Signaling Pathway
|
|
Arylhydrocarbon receptor (AhR) signaling pathway
|
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Signaling by EGFR
|
|
Semaphorin interactions
|
|
Mitotic G2-G2/M phases
|
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NOD pathwayWP2777:Translocation of GLUT4 to the Plasma Membrane
|
|
Visual phototransduction
|
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Fc epsilon receptor (FCERI) signaling
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
Signaling by the B Cell Receptor (BCR)
|
|
Inositol phosphate metabolism
|
|
DAG and IP3 signaling
|
|
Opioid Signalling
|
|
Muscle contraction
|
|
Metabolism of carbohydratesWP702:Metapathway biotransformation
|
|
Benzo(a)pyrene metabolism
|
|
Arachidonic acid metabolismWP2740:Glycerophospholipid biosynthesis
|
| References |
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
|---|
