Target Information
Target General Infomation | |||||
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Target ID |
T76497
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Former ID |
TTDR00910
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Target Name |
6-phosphogluconate dehydrogenase, decarboxylating
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Gene Name |
PGD
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Synonyms |
6-phosphogluconate dehydrogenase; 6PGDH; PGD
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Target Type |
Research
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Function |
Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
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BioChemical Class |
Short-chain dehydrogenases reductases
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Target Validation |
T76497
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UniProt ID | |||||
EC Number |
EC 1.1.1.44
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Sequence |
MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKE
MVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKG ILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAG HFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANIL KFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQA SKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIAL MWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPM PCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSS YNA |
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Pathways | |||||
BioCyc Pathway | Pentose phosphate pathway | ||||
Pentose phosphate pathway (oxidative branch) | |||||
KEGG Pathway | Pentose phosphate pathway | ||||
Glutathione metabolism | |||||
Metabolic pathways | |||||
Biosynthesis of antibiotics | |||||
Carbon metabolism | |||||
PANTHER Pathway | Pentose phosphate pathway | ||||
PathWhiz Pathway | Warburg Effect | ||||
WikiPathways | NRF2 pathway | ||||
Nuclear Receptors Meta-Pathway | |||||
Metabolism of carbohydrates | |||||
Pentose Phosphate Pathway | |||||
References | |||||
Ref 535707 | Sugar derivatives as new 6-phosphogluconate dehydrogenase inhibitors selective for the parasite Trypanosoma brucei. Bioorg Med Chem. 2003 Apr 3;11(7):1207-14. | ||||
Ref 535749 | Synthesis and biological evaluation of substrate-based inhibitors of 6-phosphogluconate dehydrogenase as potential drugs against African trypanosomiasis. Bioorg Med Chem. 2003 Jul 17;11(14):3205-14. |
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