Target Information
Target General Infomation | |||||
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Target ID |
T68547
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Former ID |
TTDS00095
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Target Name |
Histone deacetylase 1
|
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Gene Name |
HDAC1
|
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Synonyms |
HDAC1
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Target Type |
Successful
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Disease | Acute myeloid leukemia; Refractory sickle cell ulcers [ICD9:205, 282.5, 282.6; ICD10: C92.0, D57] | ||||
Cancer [ICD9: 140-229; ICD10: C00-C96] | |||||
Cutaneous T-cell lymphoma [ICD9: 202.1, 202.2; ICD10: C84.0, C84.1] | |||||
Cerebrovascular ischaemia [ICD9: 434.91; ICD10: I61-I63] | |||||
Friedreich's ataxia [ICD9: 334; ICD10: G11.1] | |||||
General leukaemia cancer [ICD9: 204-208; ICD10: C91-C95] | |||||
Hepatocellular carcinoma [ICD9: 155; ICD10: C22.0] | |||||
Hodgkin's lymphoma; Multiple myeloma [ICD9: 201, 202.8, 203.0; ICD10: C81, C81-C86, C90] | |||||
Melanoma [ICD9: 172; ICD10: C43] | |||||
Myelofibrosis; Essential thrombocythemia; Polycythemia vera [ICD9: 238.71, 289.0, 289.83, 289.9, 776.4; ICD10: C94.4, D47.1, D47.3, D75.1, D75.2, D75.8, P61.1] | |||||
Primary myelofibrosis; Post-polycythemia vera; Post-essential thrombocytopenia; Cutaneous T cell-lymphomas [ICD9: 203.0, 287.3, 287.4, 287.5, 289.0, 289.83, 776.4; ICD10: C90.0, C94.4, D47.1, D69.6, D75.1, P61.0, P61.1] | |||||
Peripheral T-cell lymphoma [ICD9: 202.7; ICD10: C84.4] | |||||
Renal cell carcinoma; Hormone refractory prostate cancer [ICD9: 140-229, 185, 189, 203.0, 205.0; ICD10: C61, C64, C90.0, C92.0] | |||||
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48] | |||||
Severe mood disorders [ICD9: 296; ICD10: F30-F39] | |||||
Type 2 diabetes [ICD9: 250; ICD10: E11] | |||||
Urea cycle disorders [ICD9: 270.6; ICD10: E72.2] | |||||
Unspecified [ICD code not available] | |||||
Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptionalregulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBPis recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.
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BioChemical Class |
Carbon-nitrogen hydrolase
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Target Validation |
T68547
|
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UniProt ID | |||||
EC Number |
EC 3.5.1.98
|
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Sequence |
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK LA |
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Drugs and Mode of Action | |||||
Drug(s) | Panobinostat | Drug Info | Approved | Multiple myeloma | [556264] |
Romidepsin | Drug Info | Approved | Cutaneous T-cell lymphoma | [530677], [542036] | |
Vorinostat | Drug Info | Approved | Cutaneous T-cell lymphoma | [537114], [541932] | |
HBI-8000 | Drug Info | Registered | Cancer | [543057], [548485] | |
NVP-LAQ824 | Drug Info | Phase 3 | Severe mood disorders | [536580] | |
Panobinostat | Drug Info | Phase 3 | Type 2 diabetes | [532695], [542511] | |
Romidepsin | Drug Info | Phase 3 | Renal cell carcinoma; Hormone refractory prostate cancer | [530677], [542036] | |
ITF2357 | Drug Info | Phase 2 | Myelofibrosis; Essential thrombocythemia; Polycythemia vera | [537520], [542513] | |
MGCD-0103 | Drug Info | Phase 2 | Solid tumours | [529426], [542038] | |
Panobinostat | Drug Info | Phase 2 | Primary myelofibrosis; Post-polycythemia vera; Post-essential thrombocytopenia; Cutaneous T cell-lymphomas | [537114], [542511] | |
Phenylbutyrate | Drug Info | Phase 2 | Urea cycle disorders | [536447], [543164] | |
Resminostat | Drug Info | Phase 2 | Hepatocellular carcinoma | [542522], [551497] | |
Romidepsin | Drug Info | Phase 2 | Peripheral T-cell lymphoma | [530677], [542036] | |
SB-623 | Drug Info | Phase 2 | Cerebrovascular ischaemia | [525202] | |
SNDX-275 | Drug Info | Phase 2 | Hodgkin's lymphoma; Multiple myeloma | [542037], [547063] | |
Sodium butyrate | Drug Info | Phase 2 | Acute myeloid leukemia; Refractory sickle cell ulcers | [531969] | |
CHR-3996 | Drug Info | Phase 1 | Solid tumours | [531893], [543102] | |
OBP-801 | Drug Info | Phase 1 | Cancer | [525149] | |
RG-2833 | Drug Info | Phase 1 | Friedreich's ataxia | [542521], [549368] | |
SB-639 | Drug Info | Phase 1 | Cancer | [531947] | |
4SC-202 | Drug Info | Preclinical | Cancer | [551497] | |
Chlamydocin | Drug Info | Preclinical | Cancer | [534024] | |
Depudecin | Drug Info | Preclinical | Cancer | [544324] | |
HC-Toxin | Drug Info | Preclinical | Cancer | [534075] | |
M-carboxycinnamic acid bishydroxamide | Drug Info | Preclinical | Cancer | [534436] | |
Scriptaid | Drug Info | Preclinical | Cancer | [536447], [542524] | |
SK-7041 | Drug Info | Preclinical | Cancer | [527163] | |
SK-7068 | Drug Info | Preclinical | Cancer | [527163] | |
AN-9 | Drug Info | Discontinued in Phase 2 | Melanoma | [545713] | |
Tacedinaline | Drug Info | Discontinued in Phase 2 | Cancer | [543093], [545228] | |
NVP-LAQ824 | Drug Info | Discontinued in Phase 1/2 | General leukaemia cancer | [536580] | |
Pyroxamide | Drug Info | Discontinued in Phase 1 | Cancer | [547711] | |
Oxamflatin | Drug Info | Terminated | Cancer | [546336] | |
Inhibitor | (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one | Drug Info | [526871] | ||
1,1,1-Trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one | Drug Info | [526450] | |||
1,1,1-Trifluoro-8-phenoxy-octan-2-one | Drug Info | [526450] | |||
2-(methylsulfonylthio)ethyl 2-propylpentanoate | Drug Info | [529333] | |||
4-Benzenesulfonylamino-N-hydroxy-benzamide | Drug Info | [526165] | |||
4-Benzoylamino-N-hydroxy-benzamide | Drug Info | [527691] | |||
4-Butyrylamino-N-hydroxy-benzamide | Drug Info | [526922] | |||
4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide | Drug Info | [526878] | |||
4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide | Drug Info | [527439] | |||
4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide | Drug Info | [526266] | |||
4-Phenylbutyrohydroxamic acid | Drug Info | [530700] | |||
4-tert-butyl-N-hydroxybenzamide | Drug Info | [528882] | |||
4SC-202 | Drug Info | [551497] | |||
5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide | Drug Info | [527056] | |||
5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione | Drug Info | [529333] | |||
5-Mercapto-pentanoic acid phenylamide | Drug Info | [527439] | |||
6-(2-Bromo-acetylamino)-hexanoic acid phenylamide | Drug Info | [527439] | |||
6-(3-Benzoyl-ureido)-hexanoic acid hydroxyamide | Drug Info | [530898] | |||
6-(9H-carbazol-9-yl)-N-hydroxyhexanamide | Drug Info | [531216] | |||
6-benzenesulfinylhexanoic acid hydroxamide | Drug Info | [527980] | |||
6-benzenesulfonylhexanoic acid hydroxamide | Drug Info | [527980] | |||
6-Mercapto-hexanoic acid phenylamide | Drug Info | [527439] | |||
6-Phenoxy-hexane-1-thiol | Drug Info | [527439] | |||
6-phenylsulfanylhexanoic acid hydroxamide | Drug Info | [527980] | |||
7-(1H-indol-5-yloxy)-N-hydroxyheptanamide | Drug Info | [528478] | |||
7-(3-Benzoyl-ureido)-heptanoic acid hydroxyamide | Drug Info | [530898] | |||
7-(4-(dimethylamino)phenoxy)-N-hydroxyheptanamide | Drug Info | [528478] | |||
7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one | Drug Info | [526871] | |||
7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one | Drug Info | [526450] | |||
7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one | Drug Info | [526871] | |||
7-(Biphenyl-4-yloxy)-heptanoic acid hydroxyamide | Drug Info | [526708] | |||
7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one | Drug Info | [526871] | |||
7-Biphenyl-4-yl-heptanoic acid hydroxyamide | Drug Info | [526847] | |||
7-Mercapto-heptanoic acid benzothiazol-2-ylamide | Drug Info | [527439] | |||
7-Mercapto-heptanoic acid biphenyl-3-ylamide | Drug Info | [527439] | |||
7-Mercapto-heptanoic acid biphenyl-4-ylamide | Drug Info | [527439] | |||
7-Mercapto-heptanoic acid phenylamide | Drug Info | [527439] | |||
7-Mercapto-heptanoic acid pyridin-3-ylamide | Drug Info | [527439] | |||
7-Mercapto-heptanoic acid quinolin-3-ylamide | Drug Info | [527439] | |||
7-mercapto-N-(4-phenylthiazol-2-yl)heptanamide | Drug Info | [529093] | |||
7-Phenoxy-heptanoic acid hydroxyamide | Drug Info | [526847] | |||
8-(3-Benzoyl-ureido)-octanoic acid hydroxyamide | Drug Info | [530898] | |||
8-(4-bromophenyl)-N-hydroxy-8-oxooctanamide | Drug Info | [529911] | |||
8-(Biphenyl-3-yloxy)-1,1,1-trifluoro-octan-2-one | Drug Info | [526450] | |||
8-(biphenyl-4-yl)-N-hydroxy-8-oxooctanamide | Drug Info | [529911] | |||
8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one | Drug Info | [526450] | |||
8-(Biphenyl-4-yloxy)-2-oxo-octanoic acid | Drug Info | [526708] | |||
8-Mercapto-octanoic acid phenylamide | Drug Info | [527439] | |||
8-Oxo-8-phenyl-octanoic acid | Drug Info | [526266] | |||
8-Oxo-8-phenyl-octanoic acid hydroxyamide | Drug Info | [526878] | |||
8-Phenyl-octanoic acid hydroxyamide | Drug Info | [526847] | |||
9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | Drug Info | [526450] | |||
9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one | Drug Info | [526450] | |||
ADS-100380 | Drug Info | [528523] | |||
ADS-102550 | Drug Info | [528523] | |||
AN-9 | Drug Info | [536272] | |||
Azithromycin-N-benzyltriazolyldecahydroxamic Acid | Drug Info | [529875] | |||
Azithromycin-N-benzyltriazolylhexahydroxamic Acid | Drug Info | [529875] | |||
Azithromycin-N-benzyltriazolylnonahydroxamic Acid | Drug Info | [529875] | |||
Azithromycin-N-benzyltriazolyloctahydroxamic Acid | Drug Info | [529875] | |||
Azithromycinarylalkylhydroxamic Acid | Drug Info | [529875] | |||
AZUMAMIDE B | Drug Info | [529411] | |||
AZUMAMIDE C | Drug Info | [529411] | |||
AZUMAMIDE E | Drug Info | [529411] | |||
Chlamydocin | Drug Info | [536509] | |||
CHR-3996 | Drug Info | [531893] | |||
Cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro-) | Drug Info | [529054] | |||
Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Pro-) | Drug Info | [529054] | |||
Cyclo(-L-Am7(S2Py)-Aib-L-Ala-D-Tic-) | Drug Info | [529054] | |||
Cyclo(-L-Am7(S2Py)-Aib-L-Ph4-D-Pro-) | Drug Info | [529054] | |||
Cyclo(-L-Am7(S2Py)-Aib-L-Ph5-D-Pro-) | Drug Info | [529054] | |||
Cyclo(-L-Am7(S2Py)-Aib-L-Phe-D-Pro-) | Drug Info | [529054] | |||
Cyclo(-L-Am7(S2Py)-Aib-L-Phg-D-Pro-) | Drug Info | [529054] | |||
Cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D-Pro-) | Drug Info | [529054] | |||
Cyclo(-L-Am7(S2Py)-Aib-L-Ser-D-Pro-) | Drug Info | [529054] | |||
Cyclo(-L-Am7(S2Py)-D-2MePhe-L-Ala-D-Pro-) | Drug Info | [529054] | |||
Cyclo(-L-Am7(S2Py)-D-A1in-L-Ala-D-Pro-) | Drug Info | [529054] | |||
Cyclo(-L-Am7(S2Py)-L-2MePhe-L-Ala-D-Pro-) | Drug Info | [529054] | |||
Cyclo(-L-Am7(S2Py)-L-A1in-L-Ala-D-Pro-) | Drug Info | [529054] | |||
Cyclostellettamine derivative | Drug Info | [527058] | |||
Depudecin | Drug Info | [536272], [536509] | |||
Desclasinose Azithromycinarylalkyl Hydroxamate | Drug Info | [529875] | |||
Gymnochrome E | Drug Info | [530729] | |||
HC-Toxin | Drug Info | [536509] | |||
ITF2357 | Drug Info | [537114], [537520] | |||
LARGAZOLE | Drug Info | [530933] | |||
M-carboxycinnamic acid bishydroxamide | Drug Info | [536272], [536509] | |||
MGCD-0103 | Drug Info | [536272], [536509], [537647] | |||
N,8-dihydroxy-8-(naphthalen-2-yl)octanamide | Drug Info | [529911] | |||
N-(2,3-Dimethylphenyl)-N'-hydroxyoctanediamide | Drug Info | [530704] | |||
N-(2,4-Dimethylphenyl)-N'-hydroxyoctanediamide | Drug Info | [530704] | |||
N-(2,5-Dimethylphenyl)-N'-hydroxyoctanediamide | Drug Info | [530704] | |||
N-(2,6-Dimethylphenyl)-N'-hydroxyoctanediamide | Drug Info | [530704] | |||
N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide | Drug Info | [529767] | |||
N-(2-aminophenyl)-4-(chroman-3-ylmethyl)benzamide | Drug Info | [529129] | |||
N-(2-aminophenyl)-4-methoxybenzamide | Drug Info | [529104] | |||
N-(2-aminophenyl)nicotinamide | Drug Info | [529767] | |||
N-(2-aminophenyl)quinoxaline-6-carboxamide | Drug Info | [529104] | |||
N-(2-Ethylphenyl)-N'-hydroxyoctanediamide | Drug Info | [530704] | |||
N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide | Drug Info | [527500] | |||
N-(2-Mercapto-ethyl)-N'-phenyl-succinamide | Drug Info | [527500] | |||
N-(3,4-Dimethylphenyl)-N'-hydroxyoctanediamide | Drug Info | [530704] | |||
N-(3,5-Dimethylphenyl)-N'-hydroxyoctanediamide | Drug Info | [530704] | |||
N-(3-Ethylphenyl)-N'-hydroxyoctanediamide | Drug Info | [530704] | |||
N-(4-aminobiphenyl-3-yl)nicotinamide | Drug Info | [529767] | |||
N-(4-Ethylphenyl)-N'-hydroxyoctanediamide | Drug Info | [530704] | |||
N-(4-hydroxybiphenyl-3-yl)benzamide | Drug Info | [529767] | |||
N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide | Drug Info | [526878] | |||
N-(6-Hydroxycarbamoyl-hexyl)-benzamide | Drug Info | [526266] | |||
N-(6-Mercapto-hexyl)-benzamide | Drug Info | [527439] | |||
N-hydroxy-2,2'-bithiophene-5-carboxamide | Drug Info | [528523] | |||
N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide | Drug Info | [527691] | |||
N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide | Drug Info | [527691] | |||
N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide | Drug Info | [527691] | |||
N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide | Drug Info | [530261] | |||
N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide | Drug Info | [527691] | |||
N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide | Drug Info | [527691] | |||
N-Hydroxy-4-(pentanoylamino-methyl)-benzamide | Drug Info | [526922] | |||
N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide | Drug Info | [526922] | |||
N-Hydroxy-4-phenylacetylamino-benzamide | Drug Info | [527691] | |||
N-hydroxy-5-(pyridin-2-yl)thiophene-2-carboxamide | Drug Info | [528523] | |||
N-hydroxy-5-(pyridin-3-yl)thiophene-2-carboxamide | Drug Info | [528523] | |||
N-hydroxy-5-(pyridin-4-yl)thiophene-2-carboxamide | Drug Info | [528523] | |||
N-hydroxy-5-phenylthiophene-2-carboxamide | Drug Info | [528523] | |||
N-hydroxy-6-oxo-6-phenylhexanamide | Drug Info | [529911] | |||
N-hydroxy-7-(4-methoxyphenyl)-7-oxoheptanamide | Drug Info | [529911] | |||
N-hydroxy-7-(naphthalen-2-yl)-7-oxoheptanamide | Drug Info | [529911] | |||
N-hydroxy-7-(naphthalen-2-yloxy)heptanamide | Drug Info | [528478] | |||
N-hydroxy-7-oxo-7-phenylheptanamide | Drug Info | [529911] | |||
N-hydroxy-8-(2-methoxyphenyl)-8-oxooctanamide | Drug Info | [529911] | |||
N-hydroxy-8-(4-methoxyphenyl)-8-oxooctanamide | Drug Info | [529911] | |||
N-hydroxy-8-(naphthalen-2-yl)non-8-enamide | Drug Info | [529911] | |||
N-hydroxy-8-(naphthalen-2-yl)oct-7-enamide | Drug Info | [529911] | |||
N-hydroxy-8-(naphthalen-2-yl)octanamide | Drug Info | [529911] | |||
N-hydroxy-8-oxo-8-(pyridin-3-yl)octanamide | Drug Info | [529911] | |||
N-hydroxy-9-oxo-9-phenylnonanamide | Drug Info | [529911] | |||
N-Hydroxy-N'-(2-methylphenyl)octanediamide | Drug Info | [530704] | |||
N-Hydroxy-N'-(3-methylphenyl)octanediamide | Drug Info | [530704] | |||
N-Hydroxy-N'-(4-methoxyphenyl)octanediamide | Drug Info | [530704] | |||
N-Hydroxy-N'-(4-methylphenyl)octanediamide | Drug Info | [530704] | |||
N-hydroxybenzo[b]thiophene-2-carboxamide | Drug Info | [529285] | |||
N1-(biphenyl-3-yl)-N8-hydroxyoctanediamide | Drug Info | [529866] | |||
N1-(biphenyl-4-yl)-N8-hydroxyoctanediamide | Drug Info | [530106] | |||
N1-hydroxy-N8-(4-phenylthiazol-2-yl)octanediamide | Drug Info | [530106] | |||
nexturastat A | Drug Info | [532053] | |||
NSC-746457 | Drug Info | [529805] | |||
NVP-LAQ824 | Drug Info | [535748] | |||
OBP-801 | Drug Info | [543680] | |||
Octanedioic acid bis-hydroxyamide | Drug Info | [526376] | |||
Octanedioic acid hydroxyamide pyridin-2-ylamide | Drug Info | [526266] | |||
Octanedioic acid hydroxyamide pyridin-4-ylamide | Drug Info | [526266] | |||
Oxamflatin | Drug Info | [536272], [536509] | |||
Panobinostat | Drug Info | [536272], [536509], [536739], [537647] | |||
Phenylbutyrate | Drug Info | [536447] | |||
PSAMMAPLIN A | Drug Info | [526878] | |||
Pyroxamide | Drug Info | [536272], [536509] | |||
Resminostat | Drug Info | [551497] | |||
Romidepsin | Drug Info | [530677] | |||
SB-623 | Drug Info | [536509] | |||
SB-639 | Drug Info | [536509] | |||
Scriptaid | Drug Info | [536272], [536447], [536509] | |||
SK-683 | Drug Info | [527104] | |||
SK-7041 | Drug Info | [536272], [536509] | |||
SK-7068 | Drug Info | [536272], [536509] | |||
SNDX-275 | Drug Info | [537114] | |||
Sodium butyrate | Drug Info | [535661], [536272] | |||
ST-2986 | Drug Info | [530016] | |||
ST-2987 | Drug Info | [530016] | |||
ST-3050 | Drug Info | [530016] | |||
Tacedinaline | Drug Info | [536272], [536509] | |||
Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester | Drug Info | [527439] | |||
Vorinostat | Drug Info | [536272], [537319], [537647] | |||
Modulator | HBI-8000 | Drug Info | [1572591] | ||
histone deacetylase-1 inhibitors (cancer) | Drug Info | [1572605] | |||
RG-2833 | Drug Info | [1572591] | |||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | Cell cycle | ||||
Notch signaling pathway | |||||
Thyroid hormone signaling pathway | |||||
Huntington' | |||||
s disease | |||||
Amphetamine addiction | |||||
Alcoholism | |||||
Epstein-Barr virus infection | |||||
Pathways in cancer | |||||
Transcriptional misregulation in cancer | |||||
Viral carcinogenesis | |||||
MicroRNAs in cancer | |||||
Chronic myeloid leukemia | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
PANTHER Pathway | Wnt signaling pathway | ||||
p53 pathway | |||||
Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
Notch signaling pathway | |||||
E2F transcription factor network | |||||
Presenilin action in Notch and Wnt signaling | |||||
Signaling events mediated by HDAC Class I | |||||
Regulation of Telomerase | |||||
Glucocorticoid receptor regulatory network | |||||
Sumoylation by RanBP2 regulates transcriptional repression | |||||
Regulation of Androgen receptor activity | |||||
IL3-mediated signaling events | |||||
Validated nuclear estrogen receptor alpha network | |||||
Retinoic acid receptors-mediated signaling | |||||
Hedgehog signaling events mediated by Gli proteins | |||||
Regulation of nuclear beta catenin signaling and target gene transcription | |||||
Validated targets of C-MYC transcriptional repression | |||||
Regulation of retinoblastoma protein | |||||
Notch-mediated HES/HEY network | |||||
Reactome | G0 and Early G1 | ||||
p75NTR negatively regulates cell cycle via SC1 | |||||
TCF transactivating complex | |||||
NOTCH1 Intracellular Domain Regulates Transcription | |||||
SMAD4 heterotrimer regulates transcription | |||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
HDACs deacetylate histones | |||||
Deactivation of the beta-catenin transactivating complex | |||||
NoRC negatively regulates rRNA expression | |||||
RNA Polymerase I Transcription Initiation | |||||
Factors involved in megakaryocyte development and platelet production | |||||
WikiPathways | SIDS Susceptibility Pathways | ||||
Notch Signaling Pathway | |||||
TGF beta Signaling Pathway | |||||
IL-6 signaling pathway | |||||
Apoptosis-related network due to altered Notch3 in ovarian cancer | |||||
SMAD4 heterotrimer | |||||
Notch Signaling Pathway | |||||
Retinoblastoma (RB) in Cancer | |||||
Neural Crest Differentiation | |||||
TWEAK Signaling Pathway | |||||
Integrated Breast Cancer Pathway | |||||
Signalling by NGF | |||||
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription | |||||
Mitotic G1-G1/S phases | |||||
Factors involved in megakaryocyte development and platelet production | |||||
Cell Cycle | |||||
Androgen receptor signaling pathway | |||||
References | |||||
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Ref 543680 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2658). |
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