Drug General Information
Drug ID	D02NWS
Former ID	DNC011077
Drug Name	4-Phenylbutyrohydroxamic acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530700]
Structure		Download 2D MOL 3D MOL
Formula	C10H13NO2
Canonical SMILES	C1=CC=C(C=C1)CCCC(=O)NO
InChI	1S/C10H13NO2/c12-10(11-13)8-4-7-9-5-2-1-3-6-9/h1-3,5-6,13H,4,7-8H2,(H,11,12)
InChIKey	UPHXPXYRKPCXHK-UHFFFAOYSA-N
PubChem Compound ID	279980
Target and Pathway
Target(s)	Histone Deacetylase 8	Target Info	Inhibitor	[530700]
	Histone deacetylase	Target Info	Inhibitor	[530700]
	Histone deacetylase 1	Target Info	Inhibitor	[530700]
	Histone deacetylase 6	Target Info	Inhibitor	[530700]
	Histone deacetylase 2	Target Info	Inhibitor	[530700]
KEGG Pathway	Alcoholism
	Viral carcinogenesishsa04110:Cell cycle
	Notch signaling pathway
	Thyroid hormone signaling pathway
	Huntington's disease
	Amphetamine addiction
	Epstein-Barr virus infection
	Pathways in cancer
	Transcriptional misregulation in cancer
	Viral carcinogenesis
	MicroRNAs in cancer
	Chronic myeloid leukemiahsa05034:Alcoholism
	Chronic myeloid leukemia
NetPath Pathway	TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway	Wnt signaling pathwayP00057:Wnt signaling pathway
	p53 pathwayP00057:Wnt signaling pathway
Pathway Interaction Database	Signaling events mediated by HDAC Class Ismad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
	Notch signaling pathway
	E2F transcription factor network
	Presenilin action in Notch and Wnt signaling
	Signaling events mediated by HDAC Class I
	Regulation of Telomerase
	Glucocorticoid receptor regulatory network
	Sumoylation by RanBP2 regulates transcriptional repression
	Regulation of Androgen receptor activity
	IL3-mediated signaling events
	Validated nuclear estrogen receptor alpha network
	Retinoic acid receptors-mediated signaling
	Hedgehog signaling events mediated by Gli proteins
	Regulation of nuclear beta catenin signaling and target gene transcription
	Validated targets of C-MYC transcriptional repression
	Regulation of retinoblastoma protein
	Notch-mediated HES/HEY networkhdac_classii_pathway:Signaling events mediated by HDAC Class II
	Direct p53 effectors
Reactome	NOTCH1 Intracellular Domain Regulates Transcription
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	HDACs deacetylate histonesR-HSA-1538133:G0 and Early G1
	p75NTR negatively regulates cell cycle via SC1
	Formation of the beta-catenin:TCF transactivating complex
	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
	HDACs deacetylate histones
	Deactivation of the beta-catenin transactivating complex
	NoRC negatively regulates rRNA expression
	RNA Polymerase I Transcription Initiation
	Factors involved in megakaryocyte development and platelet productionR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
	Assembly of the primary ciliumR-HSA-193670:p75NTR negatively regulates cell cycle via SC1
	Factors involved in megakaryocyte development and platelet production
WikiPathways	Integrated Pancreatic Cancer Pathway
	Neural Crest Differentiation
	Cell CycleWP706:SIDS Susceptibility Pathways
	Notch Signaling Pathway
	TGF beta Signaling Pathway
	IL-6 signaling pathway
	Apoptosis-related network due to altered Notch3 in ovarian cancer
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Notch Signaling Pathway
	Retinoblastoma (RB) in Cancer
	TWEAK Signaling Pathway
	Integrated Breast Cancer Pathway
	Signalling by NGF
	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
	Mitotic G1-G1/S phases
	Factors involved in megakaryocyte development and platelet production
	Cell Cycle
	Androgen receptor signaling pathwayWP2858:Ectoderm Differentiation
	Cell CycleWP61:Notch Signaling Pathway
References
Ref 530700	Nat Chem Biol. 2010 Mar;6(3):238-243. Epub 2010 Feb 7.Chemical phylogenetics of histone deacetylases.
Ref 530700	Nat Chem Biol. 2010 Mar;6(3):238-243. Epub 2010 Feb 7.Chemical phylogenetics of histone deacetylases.

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