Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02VHD
|
||||
| Former ID |
DIB020929
|
||||
| Drug Name |
SCH51866
|
||||
| Synonyms |
SCH 51866; SCH-51866
|
||||
| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C19H18F3N5O
|
||||
| InChI |
InChI=1S/C19H18F3N5O/c1-26-17(28)15-16(27-13-4-2-3-12(13)23-18(26)27)25-14(24-15)9-10-5-7-11(8-6-10)19(20,21)22/h5-8,12-13H,2-4,9H2,1H3,(H,24,25)/t12-,13+/m1/s1
|
||||
| InChIKey |
JOSMPBVYYKRYLG-OLZOCXBDSA-N
|
||||
| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | CGMP-specific 3',5'-cyclic phosphodiesterase | Target Info | Inhibitor | [2] | |
| PDE1A | Target Info | Inhibitor | [2] | ||
| Phosphodiesterase (PDE) 1B | Target Info | Inhibitor | [2] | ||
| Phosphodiesterase (PDE) 7B | Target Info | Inhibitor | [3] | ||
| PDE1C | Target Info | Inhibitor | [2] | ||
| Phosphodiesterase (PDE) 9 | Target Info | Inhibitor | [4] | ||
| KEGG Pathway | Purine metabolism | ||||
| cGMP-PKG signaling pathwayhsa00230:Purine metabolism | |||||
| Calcium signaling pathway | |||||
| Morphine addictionhsa00230:Purine metabolism | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| Pathway Interaction Database | Regulation of Androgen receptor activity | ||||
| Reactome | cGMP effectsR-HSA-418457:cGMP effects | ||||
| G alpha (s) signalling eventsR-HSA-418555:G alpha (s) signalling eventsR-HSA-418457:cGMP effects | |||||
| WikiPathways | G Protein Signaling Pathways | ||||
| DAG and IP3 signaling | |||||
| Opioid SignallingWP35:G Protein Signaling Pathways | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5270). | ||||
| REF 2 | Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor. J Cardiovasc Pharmacol. 1996 Dec;28(6):862-9. | ||||
| REF 3 | Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun. 2000 May 19;271(3):575-83. | ||||
| REF 4 | Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J Biol Chem. 1998 Jun 19;273(25):15559-64. | ||||
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