Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T20578
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| Former ID |
TTDI01952
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| Target Name |
Phosphodiesterase (PDE) 7B
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| Gene Name |
PDE7B
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| Synonyms |
cAMPspecific 3',5'cyclic phosphodiesterase 7B; PDE7B
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| Target Type |
Discontinued
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| Disease | Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89] | ||||
| Function |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain.
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| BioChemical Class |
Phosphoric diester hydrolases
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| UniProt ID | |||||
| EC Number |
EC 3.1.4.17
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| Sequence |
MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYS
GEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIF LFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAAD VTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMS VLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHN KDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ HRSRGSSGSGPDHDHAGQGTESEEQEGDSP |
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| Structure |
1ZKL; 3G3N; 4PM0; 1LXW
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| Drugs and Mode of Action | |||||
| Drug(s) | PF-3557156 | Drug Info | Discontinued in Phase 1 | Pain | [1] |
| Inhibitor | BRL50481 | Drug Info | [2] | ||
| SCH51866 | Drug Info | [3] | |||
| Modulator | PF-3557156 | Drug Info | |||
| Pathways | |||||
| KEGG Pathway | Purine metabolism | ||||
| Morphine addiction | |||||
| Reactome | G alpha (s) signalling events | ||||
| WikiPathways | G Protein Signaling Pathways | ||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026842) | ||||
| REF 2 | New classes of PDE7 inhibitors identified by a fission yeast-based HTS. J Biomol Screen. 2010 Apr;15(4):359-67. | ||||
| REF 3 | Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun. 2000 May 19;271(3):575-83. | ||||
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