Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00ANJ
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| Former ID |
DNC007188
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| Drug Name |
1-dodecyl-1H-indole-2,3-dione
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| Synonyms |
1-dodecylindoline-2,3-dione
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [528749] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C20H29NO2
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| Canonical SMILES |
CCCCCCCCCCCCN1C2=CC=CC=C2C(=O)C1=O
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| InChI |
1S/C20H29NO2/c1-2-3-4-5-6-7-8-9-10-13-16-21-18-15-12-11-14-17(18)19(22)20(21)23/h11-12,14-15H,2-10,13,16H2,1H3
|
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| InChIKey |
GQEQKTGRIPEAKW-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Liver carboxylesterase | Target Info | Inhibitor | [528749] | |
| M-phase inducer phosphatase 1 | Target Info | Inhibitor | [529444] | ||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| TGF_beta_Receptor Signaling Pathway | |||||
| Reactome | E2F mediated regulation of DNA replication | ||||
| G0 and Early G1 | |||||
| Polo-like kinase mediated events | |||||
| Cyclin B2 mediated events | |||||
| Activation of ATR in response to replication stress | |||||
| Cyclin E associated events during G1/S transition | |||||
| G1/S-Specific Transcription | |||||
| Cyclin A/B1 associated events during G2/M transition | |||||
| Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | |||||
| Cyclin A:Cdk2-associated events at S phase entry | |||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Heroin metabolism | |||||
| Irinotecan Pathway | |||||
| Fluoropyrimidine Activity | |||||
| Phase I biotransformations, non P450WP707:DNA Damage Response | |||||
| G1 to S cell cycle control | |||||
| S Phase | |||||
| ATM Signaling Pathway | |||||
| Retinoblastoma (RB) in Cancer | |||||
| Prostate Cancer | |||||
| Integrated Breast Cancer Pathway | |||||
| Integrated Cancer pathway | |||||
| Mitotic G1-G1/S phases | |||||
| Cell Cycle | |||||
| Cell Cycle Checkpoints | |||||
| miRNAs involved in DNA damage response | |||||
| miRNA Regulation of DNA Damage Response | |||||
| References | |||||
| Ref 528749 | J Med Chem. 2007 Apr 19;50(8):1876-85. Epub 2007 Mar 23.Selective inhibition of carboxylesterases by isatins, indole-2,3-diones. | ||||
| Ref 529444 | Bioorg Med Chem Lett. 2008 Jun 1;18(11):3350-3. Epub 2008 Apr 15.Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors. | ||||
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