Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T62704
|
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| Former ID |
TTDS00423
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| Target Name |
3-beta-HSD
|
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| Synonyms |
3-beta-HSD; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3BH; Delta-5-3-ketosteroid isomerase; HSD3B1; HSDB3A; Progesterone reductase; Steroid Delta-isomerase; Trophoblast antigen FDO161G
|
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| Target Type |
Research
|
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| Disease | Termination of early pregnancy [ICD9: 779.6; ICD10: O04] | ||||
| BioChemical Class |
Short-chain dehydrogenases reductases
|
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| EC Number |
EC 5.3.3.1
|
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| Inhibitor | 3-Beta-Hydroxy-5-Androsten-17-One | Drug Info | [1] | ||
| 4-MA | Drug Info | [2] | |||
| 5alpha-Androstan-3,17-Dione | Drug Info | [1] | |||
| Beta-Mercaptoethanol | Drug Info | [1] | |||
| Epostane | Drug Info | [3] | |||
| Equilenin | Drug Info | [1] | |||
| Agonist | 4-Androstenedione | Drug Info | [1] | ||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 2 | Activity and inhibition of 3-beta-hydroxysteroid dehydrogenase/delta-5-4-isomerase in human skin. Skin Pharmacol. 1997;10(3):160-8. | ||||
| REF 3 | Termination of early pregnancy by the 3 beta-hydroxysteroid dehydrogenase inhibitor epostane. N Engl J Med. 1988 Sep 29;319(13):813-7. | ||||
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