| Drug General Information |
| Drug ID |
D06HKH
|
| Former ID |
DNC002486
|
| Drug Name |
Beta-Mercaptoethanol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C2H6OS
|
| Canonical SMILES |
C(CS)O
|
| InChI |
1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2
|
| InChIKey |
DGVVWUTYPXICAM-UHFFFAOYSA-N
|
| CAS Number |
CAS 60-24-2
|
| PubChem Compound ID |
|
| PubChem Substance ID |
4181, 70162, 589479, 599920, 825659, 831555, 831821, 831822, 835442, 835443, 835444, 835445, 835446, 835447, 835448, 835449, 835450, 835451, 835456, 837880, 3133763, 5622934, 6436212, 6436356, 7886253, 7890431, 7979607, 8006454, 8006457, 8006460, 8006462, 8006465, 8006468, 8006471, 8006474, 8006477, 8006479, 8006482, 8006485, 8006488, 8006491, 8006494, 8006497, 8006500, 8006503, 8006506, 8006509, 8006512, 8006514, 8006517
|
| Target and Pathway |
| Target(s) |
3-beta-HSD |
Target Info |
Inhibitor |
[1]
|
|---|
| Thymidylate synthase |
Target Info |
Inhibitor |
[1]
|
| Heparin-binding growth factor 2 |
Target Info |
Inhibitor |
[1]
|
| M-phase inducer phosphatase 2 |
Target Info |
Inhibitor |
[1]
|
| High mobility group protein 1 |
Target Info |
Inhibitor |
[1]
|
| Adenylosuccinate synthetase |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase II |
Target Info |
Inhibitor |
[1]
|
| Delta-aminolevulinic acid dehydratase |
Target Info |
Inhibitor |
[1]
|
| Carbonic anhydrase |
Target Info |
Inhibitor |
[1]
|
| Dihydrofolate reductase |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Pyrimidine deoxyribonucleotides biosynthesis from CTP
|
|
Pyrimidine deoxyribonucleotides de novo biosynthesis
|
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Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
|
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Superpathway of pyrimidine deoxyribonucleoside salvage
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DTMP de novo biosynthesis (mitochondrial)
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Pyrimidine deoxyribonucleosides salvagePWY-5920:Heme biosynthesis
|
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Tetrapyrrole biosynthesis
|
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KEGG Pathway
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Pyrimidine metabolism
|
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One carbon pool by folate
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Metabolic pathwayshsa04010:MAPK signaling pathway
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Ras signaling pathway
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Rap1 signaling pathway
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PI3K-Akt signaling pathway
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Signaling pathways regulating pluripotency of stem cells
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Regulation of actin cytoskeleton
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Pathways in cancer
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Proteoglycans in cancer
|
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Melanomahsa04010:MAPK signaling pathway
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Cell cycle
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Progesterone-mediated oocyte maturation
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MicroRNAs in cancerhsa03410:Base excision repairhsa00910:Nitrogen metabolism
|
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Proximal tubule bicarbonate reclamation
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Collecting duct acid secretion
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Gastric acid secretion
|
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Pancreatic secretion
|
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Bile secretionhsa00860:Porphyrin and chlorophyll metabolism
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Metabolic pathways
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NetPath Pathway
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IL1 Signaling PathwayNetPath_14:IL2 Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
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Wnt Signaling PathwayNetPath_23:TSH Signaling Pathway
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TCR Signaling PathwayNetPath_16:IL4 Signaling Pathway
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EGFR1 Signaling Pathway
|
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PANTHER Pathway
|
De novo pyrimidine deoxyribonucleotide biosynthesis
|
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Formyltetrahydroformate biosynthesisP00059:p53 pathwayP02746:Heme biosynthesis
|
|
Pathway Interaction Database
|
E2F transcription factor networkglypican_1pathway:Glypican 1 network
|
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Angiopoietin receptor Tie2-mediated signaling
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Integrins in angiogenesis
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Syndecan-4-mediated signaling events
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FGF signaling pathwayplk1_pathway:PLK1 signaling events
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FOXM1 transcription factor network
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p38 signaling mediated by MAPKAP kinases
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Aurora A signalingintegrin3_pathway:Beta3 integrin cell surface interactions
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amb2 Integrin signaling
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Endogenous TLR signaling
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PathWhiz Pathway
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Pyrimidine MetabolismPW000158:Porphyrin MetabolismPW000024:Folate Metabolism
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Pterine Biosynthesis
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Reactome
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E2F mediated regulation of DNA replication
|
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Pyrimidine biosynthesis
|
|
G1/S-Specific TranscriptionR-HSA-109704:PI3K Cascade
|
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PIP3 activates AKT signaling
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FGFR4 ligand binding and activation
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FGFR3c ligand binding and activation
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FGFR2c ligand binding and activation
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FGFR2b ligand binding and activation
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FGFR3 mutant receptor activation
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Activated point mutants of FGFR2
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Constitutive Signaling by Aberrant PI3K in Cancer
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POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
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Syndecan interactions
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Non-integrin membrane-ECM interactions
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Phospholipase C-mediated cascade: FGFR1
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Phospholipase C-mediated cascade
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Phospholipase C-mediated cascade
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Phospholipase C-mediated cascade
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SHC-mediated cascade:FGFR1
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PI-3K cascade:FGFR1
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FRS-mediated FGFR1 signaling
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PI-3K cascade:FGFR2
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SHC-mediated cascade:FGFR2
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FRS-mediated FGFR2 signaling
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SHC-mediated cascade:FGFR3
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FRS-mediated FGFR3 signaling
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PI-3K cascade:FGFR3
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FRS-mediated FGFR4 signaling
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SHC-mediated cascade:FGFR4
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PI-3K cascade:FGFR4
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Negative regulation of FGFR1 signaling
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Negative regulation of FGFR2 signaling
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Negative regulation of FGFR3 signaling
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Negative regulation of FGFR4 signaling
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RAF/MAP kinase cascadeR-HSA-157881:Cyclin B2 mediated events
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Cyclin A/B1 associated events during G2/M transition
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Cyclin A:Cdk2-associated events at S phase entryR-HSA-1810476:RIP-mediated NFkB activation via ZBP1
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Activation of DNA fragmentation factor
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DEx/H-box helicases activate type I IFN and inflammatory cytokines production
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TAK1 activates NFkB by phosphorylation and activation of IKKs complex
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Advanced glycosylation endproduct receptor signaling
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TRAF6 mediated NF-kB activationR-HSA-1237044:Erythrocytes take up carbon dioxide and release oxygen
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Erythrocytes take up oxygen and release carbon dioxide
|
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Reversible hydration of carbon dioxideR-HSA-113510:E2F mediated regulation of DNA replication
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Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
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Metabolism of folate and pterines
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G1/S-Specific Transcription
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WikiPathways
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Trans-sulfuration and one carbon metabolism
|
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Retinoblastoma (RB) in Cancer
|
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One Carbon Metabolism
|
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Integrated Pancreatic Cancer Pathway
|
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miR-targeted genes in muscle cell - TarBase
|
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miR-targeted genes in lymphocytes - TarBase
|
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miR-targeted genes in leukocytes - TarBase
|
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miR-targeted genes in epithelium - TarBase
|
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Metabolism of nucleotides
|
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Fluoropyrimidine ActivityWP51:Regulation of Actin Cytoskeleton
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Endochondral Ossification
|
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Differentiation Pathway
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Cardiac Hypertrophic Response
|
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Syndecan interactions
|
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Extracellular matrix organization
|
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Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
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PIP3 activates AKT signaling
|
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Cardiac Progenitor Differentiation
|
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Neural Crest Differentiation
|
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miR-targeted genes in squamous cell - TarBase
|
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Signaling by FGFR
|
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MicroRNAs in cardiomyocyte hypertrophy
|
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AngiogenesisWP615:Senescence and Autophagy in Cancer
|
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MAPK Signaling Pathway
|
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Prostate Cancer
|
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Integrated Breast Cancer Pathway
|
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Integrated Cancer pathway
|
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Mitotic G2-G2/M phases
|
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Cell CycleWP710:DNA Damage Response (only ATM dependent)
|
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Cytosolic sensors of pathogen-associated DNA
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TAK1 activates NFkB by phosphorylation and activation of IKKs complex
|
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RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
|
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Apoptotic execution phase
|
|
Advanced glycosylation endproduct receptor signalingWP2770:Reversible Hydration of Carbon Dioxide
|
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Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
|
|
Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP561:Heme Biosynthesis
|
|
Metabolism of porphyrins
|
| References |
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. |
|---|
