Target Validation Information | |||||
---|---|---|---|---|---|
Target ID | T00140 | ||||
Target Name | Arachidonate 5-lipoxygenase | ||||
Target Type | Successful |
||||
Drug Potency against Target | 1,8-Dichloro-10H-anthracen-9-one | Drug Info | IC50 = 4000 nM | [534507] | |
4,5-Dihydroxy-10H-anthracen-9-one | Drug Info | IC50 = 4000 nM | [534507] | ||
2-Phenethyl-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 550 nM | [529474] | ||
1-Hydroxy-10H-anthracen-9-one | Drug Info | IC50 = 13000 nM | [534507] | ||
10-Acetyl-1,8-dihydroxy-10H-anthracen-9-one | Drug Info | IC50 = 18000 nM | [534507] | ||
1-Methyl-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 3000 nM | [529474] | ||
Naphthalene-2-carboxylic acid hydroxyamide | Drug Info | IC50 = 14000 nM | [532087] | ||
3-Biphenyl-3-yl-N-hydroxy-N-methyl-acrylamide | Drug Info | IC50 = 70 nM | [532087] | ||
NAFAZATROM | Drug Info | IC50 = 6000 nM | [532133] | ||
N-Hydroxy-3-naphthalen-2-yl-propionamide | Drug Info | IC50 = 9700 nM | [532087] | ||
4-Hydroxy-5-methoxy-10H-anthracen-9-one | Drug Info | IC50 = 2000 nM | [534507] | ||
N-Hydroxy-4-iodo-benzamide | Drug Info | IC50 = 15000 nM | [532087] | ||
N-(4-Ethylphenyl)-5-methylbenzo[d]oxazol-2-amine | Drug Info | IC50 = 120 nM | [531178] | ||
Phenanthrene-3-carboxylic acid hydroxyamide | Drug Info | IC50 = 1200 nM | [532087] | ||
Acetic acid 2-phenyl-5-propyl-thiazol-4-yl ester | Drug Info | IC50 = 660 nM | [531065] | ||
PYROGALLOL | Drug Info | IC50 = 4000 nM | [534507] | ||
3,4-Dihydroxy-10H-anthracen-9-one | Drug Info | IC50 = 4000 nM | [534507] | ||
JUGLONE | Drug Info | IC50 = 17000 nM | [534507] | ||
1,5-Dihydroxy-10H-anthracen-9-one | Drug Info | IC50 = 10000 nM | [534507] | ||
1,3,8-Trihydroxy-6-methyl-10H-anthracen-9-one | Drug Info | IC50 = 14000 nM | [534507] | ||
2-Phenyl-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 310 nM | [529474] | ||
2-(4-Phenyl-butyl)-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 780 nM | [529474] | ||
1,2-Dihydro-indazol-3-one | Drug Info | IC50 = 2000 nM | [529474] | ||
2-Pyridin-2-ylmethyl-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 3100 nM | [529474] | ||
N-Hydroxy-N-methyl-benzamide | Drug Info | IC50 = 14000 nM | [532087] | ||
N-Hydroxy-3-naphthalen-2-yl-N-p-tolyl-acrylamide | Drug Info | IC50 = 280 nM | [532087] | ||
N-Hydroxy-4-isobutyl-benzamide | Drug Info | IC50 = 6000 nM | [532087] | ||
N-Hydroxy-3-naphthalen-2-yl-N-phenyl-acrylamide | Drug Info | IC50 = 52 nM | [532087] | ||
2'-Nitro-biphenyl-4-carboxylic acid hydroxyamide | Drug Info | IC50 = 8300 nM | [532087] | ||
3-Benzoyl-N-hydroxy-benzamide | Drug Info | IC50 = 7900 nM | [532087] | ||
NAPHTHAZALIN | Drug Info | IC50 = 3000 nM | [534507] | ||
N-Phenylbenzo[d]oxazol-2-amine | Drug Info | IC50 = 8910 nM | [531178] | ||
N-(3-Bromophenyl)-5-methoxybenzo[d]oxazol-2-amine | Drug Info | IC50 = 2030 nM | [531178] | ||
N-Hydroxy-3-naphthalen-2-yl-acrylamide | Drug Info | IC50 = 950 nM | [532087] | ||
2-Biphenyl-4-yl-N-hydroxy-N-methyl-acetamide | Drug Info | IC50 = 360 nM | [532087] | ||
N-(2-Ethylphenyl)-5-methylbenzo[d]oxazol-2-amine | Drug Info | IC50 = 5660 nM | [531178] | ||
1,8-Dihydroxy-2-propionyl-10H-anthracen-9-one | Drug Info | IC50 = 6000 nM | [534507] | ||
N-Hydroxy-2-naphthalen-2-yl-acetamide | Drug Info | IC50 = 19000 nM | [532087] | ||
Hexanoic acid 2,5-diphenyl-thiazol-4-yl ester | Drug Info | IC50 = 500 nM | [531065] | ||
Biphenyl-3-carboxylic acid hydroxyamide | Drug Info | IC50 = 6000 nM | [532087] | ||
2-(4-Butoxy-phenyl)-N-hydroxy-N-methyl-acetamide | Drug Info | IC50 = 720 nM | [532087] | ||
10-Benzoyl-1,8-dihydroxy-10H-anthracen-9-one | Drug Info | IC50 = 4000 nM | [534507] | ||
Anthracene-2-carboxylic acid hydroxyamide | Drug Info | IC50 = 980 nM | [532087] | ||
Biphenyl-4-carboxylic acid hydroxyamide | Drug Info | IC50 = 4100 nM | [532087] | ||
N-hydroxy-4-(naphthalen-1-yl)benzamide | Drug Info | IC50 = 180 nM | [532087] | ||
1-Hydroxy-8-methoxy-10H-anthracen-9-one | Drug Info | IC50 = 12000 nM | [534507] | ||
Phenanthrene-2-carboxylic acid hydroxyamide | Drug Info | IC50 = 1900 nM | [532087] | ||
ANTHRONE | Drug Info | IC50 = 2000 nM | [534507] | ||
4-Pentadeca-1,3,6-trienylsulfanyl-butyric acid | Drug Info | IC50 = 7200 nM | [532133] | ||
2-(4-Butoxy-phenoxy)-N-hydroxy-acetamide | Drug Info | IC50 = 5300 nM | [532087] | ||
2-Thiophen-2-ylmethyl-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 400 nM | [529474] | ||
REV-5901 | Drug Info | IC50 = 3000 nM | [529474] | ||
N-Hydroxy-N-methyl-2,3,3-triphenyl-acrylamide | Drug Info | IC50 = 2700 nM | [532087] | ||
2-(4-Butoxy-phenoxy)-N-hydroxy-N-methyl-acetamide | Drug Info | IC50 = 890 nM | [532087] | ||
2-(4-Butoxy-phenoxy)-N-hydroxy-propionamide | Drug Info | IC50 = 8060 nM | [532087] | ||
N-Hydroxy-4-naphthalen-2-yl-benzamide | Drug Info | IC50 = 330 nM | [532087] | ||
N-Hydroxy-2-methyl-3-naphthalen-2-yl-acrylamide | Drug Info | IC50 = 1800 nM | [532087] | ||
4-Bromo-N-hydroxy-benzamide | Drug Info | IC50 = 14000 nM | [532087] | ||
3-(4-Butoxy-phenyl)-N-hydroxy-N-methyl-acrylamide | Drug Info | IC50 = 100 nM | [532087] | ||
N-Hydroxy-N-methyl-3-naphthalen-1-yl-acrylamide | Drug Info | IC50 = 210 nM | [532087] | ||
2-(4-Methoxy-phenyl)-5-phenyl-thiazol-4-ol | Drug Info | IC50 = 450 nM | [531065] | ||
5-Methyl-2-p-tolyl-thiazol-4-ol | Drug Info | IC50 = 1200 nM | [531065] | ||
Acetic acid 5-butyl-2-phenyl-thiazol-4-yl ester | Drug Info | IC50 = 500 nM | [531065] | ||
5-Methoxy-N-phenylbenzo[d]oxazol-2-amine | Drug Info | IC50 = 7880 nM | [531178] | ||
N-Hydroxy-N-methyl-3-phenanthren-2-yl-acrylamide | Drug Info | IC50 = 130 nM | [532087] | ||
N-Hydroxy-N-methyl-3-phenanthren-3-yl-acrylamide | Drug Info | IC50 = 100 nM | [532087] | ||
N-(4-Ethylphenyl)benzo[d]oxazol-2-amine | Drug Info | IC50 = 1210 nM | [531178] | ||
N-Hydroxy-N-methyl-2-naphthalen-2-yl-propionamide | Drug Info | IC50 = 590 nM | [532087] | ||
N-Hydroxy-3-phenyl-acrylamide | Drug Info | IC50 = 12000 nM | [532087] | ||
4-Butoxy-N-hydroxy-N-methyl-benzamide | Drug Info | IC50 = 490 nM | [532087] | ||
5-Chloro-N-phenylbenzo[d]oxazol-2-amine | Drug Info | IC50 = 4500 nM | [531178] | ||
5-Chloro-N-(4-ethylphenyl)benzo[d]oxazol-2-amine | Drug Info | IC50 = 950 nM | [531178] | ||
1,8,9-Trimethoxy-9,10-dihydro-anthracene | Drug Info | IC50 = 10000 nM | [534507] | ||
Licofelone | Drug Info | IC50 = 160 nM | [527799] | ||
5-Methyl-N-phenylbenzo[d]oxazol-2-amine | Drug Info | IC50 = 4600 nM | [531178] | ||
4-(1H-indol-3-yl)-1-morpholinobutan-1-one | Drug Info | IC50 = 2060 nM | [528710] | ||
Zileuton | Drug Info | IC50 = 500~1000 nM | [535615] | ||
1-Benzyl-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 3400 nM | [529474] | ||
2-Methyl-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 1300 nM | [529474] | ||
2-(3-Phenyl-propyl)-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 540 nM | [529474] | ||
2-(1H-Indol-3-ylmethyl)-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 1100 nM | [529474] | ||
2-Pyridin-3-ylmethyl-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 1500 nM | [529474] | ||
A-78773 | Drug Info | IC50 = 298 nM | [534630] | ||
N-hydroxy-N-[1-(4-isobutylphenyl)ethyl]urea | Drug Info | IC50 = 600 nM | [534335] | ||
BAICALEIN | Drug Info | IC50 = 10000 nM | [529474] | ||
2-Benzyl-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 360 nM | [529474] | ||
2-Pyridin-4-ylmethyl-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 2400 nM | [529474] | ||
2-Naphthalen-1-ylmethyl-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 610 nM | [529474] | ||
2-Furan-2-ylmethyl-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 270 nM | [529474] | ||
2-Naphthalen-2-ylmethyl-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 970 nM | [529474] | ||
2-Thiazol-5-ylmethyl-1,2-dihydro-indazol-3-one | Drug Info | IC50 = 1800 nM | [529474] | ||
3-Biphenyl-4-yl-N-hydroxy-N-methyl-acrylamide | Drug Info | IC50 = 130 nM | [532087] | ||
N-Hydroxy-N-methyl-3-phenanthren-9-yl-acrylamide | Drug Info | IC50 = 120 nM | [532087] | ||
1,2-Dihydroxy-10H-anthracen-9-one | Drug Info | IC50 = 4000 nM | [534507] | ||
N-Hydroxy-N-methyl-3-naphthalen-2-yl-acrylamide | Drug Info | IC50 = 100 nM | [533474] | ||
Ibuproxam | Drug Info | IC50 = 4840 nM | [533474] | ||
N-Hydroxy-N-methyl-3-naphthalen-2-yl-propionamide | Drug Info | IC50 = 380 nM | [532087] | ||
TEBUFELONE | Drug Info | IC50 = 3000 nM | [534599] | ||
4,5-Dimethoxy-10H-anthracen-9-one | Drug Info | IC50 = 8000 nM | [534507] | ||
TZI-41127 | Drug Info | IC50 = 110 nM | |||
References | |||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532133 | J Med Chem. 1990 Apr;33(4):1163-70.Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 531178 | Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. Epub 2010 Oct 1.Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 531065 | J Med Chem. 1991 Jul;34(7):2158-65.4-hydroxythiazole inhibitors of 5-lipoxygenase. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 531178 | Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. Epub 2010 Oct 1.Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. | ||||
Ref 531178 | Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. Epub 2010 Oct 1.Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 531178 | Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. Epub 2010 Oct 1.Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 531065 | J Med Chem. 1991 Jul;34(7):2158-65.4-hydroxythiazole inhibitors of 5-lipoxygenase. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 532133 | J Med Chem. 1990 Apr;33(4):1163-70.Design, synthesis, and 5-lipoxygenase-inhibiting properties of 1-thio-substituted butadienes. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 531065 | J Med Chem. 1991 Jul;34(7):2158-65.4-hydroxythiazole inhibitors of 5-lipoxygenase. | ||||
Ref 531065 | J Med Chem. 1991 Jul;34(7):2158-65.4-hydroxythiazole inhibitors of 5-lipoxygenase. | ||||
Ref 531065 | J Med Chem. 1991 Jul;34(7):2158-65.4-hydroxythiazole inhibitors of 5-lipoxygenase. | ||||
Ref 531178 | Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. Epub 2010 Oct 1.Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 531178 | Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. Epub 2010 Oct 1.Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 531178 | Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. Epub 2010 Oct 1.Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. | ||||
Ref 531178 | Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. Epub 2010 Oct 1.Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 527799 | J Med Chem. 2005 Oct 20;48(21):6523-43.Designed multiple ligands. An emerging drug discovery paradigm. | ||||
Ref 531178 | Bioorg Med Chem. 2010 Nov 1;18(21):7580-5. Epub 2010 Oct 1.Synthesis and evaluation of benzoxazole derivatives as 5-lipoxygenase inhibitors. | ||||
Ref 528710 | Bioorg Med Chem Lett. 2007 May 1;17(9):2414-20. Epub 2007 Feb 17.Indole derivatives as potent inhibitors of 5-lipoxygenase: design, synthesis, biological evaluation, and molecular modeling. | ||||
Ref 535615 | Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase. Biochem Pharmacol. 2002 Dec 15;64(12):1767-75. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 534630 | J Med Chem. 1998 May 21;41(11):1970-9.(+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist. | ||||
Ref 534335 | J Med Chem. 1997 Feb 28;40(5):819-24.Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 529474 | J Med Chem. 1991 Mar;34(3):1028-36.Indazolinones, a new series of redox-active 5-lipoxygenase inhibitors with built-in selectivity and oral activity. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
Ref 534507 | J Med Chem. 1997 Nov 7;40(23):3773-80.Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. | ||||
Ref 533474 | J Med Chem. 1987 Nov;30(11):2121-6.In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase. | ||||
Ref 533474 | J Med Chem. 1987 Nov;30(11):2121-6.In vivo characterization of hydroxamic acid inhibitors of 5-lipoxygenase. | ||||
Ref 532087 | J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. | ||||
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