Drug General Information
Drug ID
D03HNC
Former ID
DNC011656
Drug Name
N-hydroxy-4-(naphthalen-1-yl)benzamide
Synonyms
N-Hydroxy-4-naphthalen-1-yl-benzamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528719]
Structure
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2D MOL

3D MOL

Formula
C17H13NO2
Canonical SMILES
C1=CC=C2C(=C1)C=CC=C2C3=CC=C(C=C3)C(=O)NO
InChI
1S/C17H13NO2/c19-17(18-20)14-10-8-13(9-11-14)16-7-3-5-12-4-1-2-6-15(12)16/h1-11,20H,(H,18,19)
InChIKey
PKQVYJOPUCLLCD-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Histone Deacetylase 8 Target Info Inhibitor [528719]
Arachidonate 5-lipoxygenase Target Info Inhibitor [532087]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Alcoholism
Viral carcinogenesishsa00590:Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Wnt signaling pathway
Pathway Interaction Database Signaling events mediated by HDAC Class I
PathWhiz Pathway Arachidonic Acid Metabolism
Reactome NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
WikiPathways Integrated Pancreatic Cancer Pathway
Neural Crest Differentiation
Cell CycleWP2877:Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 528719Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. Epub 2007 Feb 25.Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.
Ref 528719Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8. Epub 2007 Feb 25.Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.
Ref 532087J Med Chem. 1990 Mar;33(3):992-8.Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships.

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