| Drug General Information |
| Drug ID |
D0F8DL
|
| Former ID |
DNC001280
|
| Drug Name |
SB 203580
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Terminated |
[1],
[2]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C21H16FN3OS
|
| InChI |
InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
|
| InChIKey |
CDMGBJANTYXAIV-UHFFFAOYSA-N
|
| CAS Number |
CAS 152121-47-6
|
| PubChem Compound ID |
|
| PubChem Substance ID |
794099, 3727017, 4881696, 7885391, 7980717, 11113952, 11113953, 11120137, 11120625, 11121113, 11147220, 11548420, 14720324, 14779945, 14804412, 24899788, 26752101, 26759478, 26759483, 33499832, 46391337, 46392883, 46513744, 48110703, 49684193, 50070516, 50071154, 50100115, 50104755, 53788760, 56310897, 56311795, 57395287, 80363426, 84943990, 85787285, 87363401, 92310088, 99217496, 99301000, 99302824, 99374146, 99437224, 103163913, 103904989, 104425365, 109693171, 124756980, 124886984, 125163785
|
| Target and Pathway |
| Target(s) |
Mitogen-activated protein kinase 14 |
Target Info |
Inhibitor |
[3],
[4]
|
|---|
| Prostaglandin G/H synthase 2 |
Target Info |
Inhibitor |
[5]
|
| Interleukin 1 receptor |
Target Info |
Antagonist |
[6]
|
|
BioCyc Pathway
|
Aspirin-triggered lipoxin biosynthesis
|
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Aspirin triggered resolvin D biosynthesis
|
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C20 prostanoid biosynthesis
|
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Aspirin triggered resolvin E biosynthesis
|
|
KEGG Pathway
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MAPK signaling pathway
|
|
Rap1 signaling pathway
|
|
FoxO signaling pathway
|
|
Sphingolipid signaling pathway
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Adrenergic signaling in cardiomyocytes
|
|
VEGF signaling pathway
|
|
Osteoclast differentiation
|
|
Signaling pathways regulating pluripotency of stem cells
|
|
Platelet activation
|
|
Toll-like receptor signaling pathway
|
|
NOD-like receptor signaling pathway
|
|
RIG-I-like receptor signaling pathway
|
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T cell receptor signaling pathway
|
|
Fc epsilon RI signaling pathway
|
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TNF signaling pathway
|
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Leukocyte transendothelial migration
|
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Neurotrophin signaling pathway
|
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Retrograde endocannabinoid signaling
|
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Dopaminergic synapse
|
|
Inflammatory mediator regulation of TRP channels
|
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GnRH signaling pathway
|
|
Progesterone-mediated oocyte maturation
|
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Prolactin signaling pathway
|
|
Amyotrophic lateral sclerosis (ALS)
|
|
Epithelial cell signaling in Helicobacter pylori infection
|
|
Shigellosis
|
|
Salmonella infection
|
|
Pertussis
|
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Leishmaniasis
|
|
Chagas disease (American trypanosomiasis)
|
|
Toxoplasmosis
|
|
Tuberculosis
|
|
Hepatitis C
|
|
Influenza A
|
|
Epstein-Barr virus infection
|
|
Proteoglycans in cancerhsa00590:Arachidonic acid metabolism
|
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Metabolic pathways
|
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NF-kappa B signaling pathway
|
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Serotonergic synapse
|
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Ovarian steroidogenesis
|
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Oxytocin signaling pathway
|
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Regulation of lipolysis in adipocytes
|
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Pathways in cancer
|
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Chemical carcinogenesis
|
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MicroRNAs in cancer
|
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Small cell lung cancerhsa04010:MAPK signaling pathway
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Cytokine-cytokine receptor interaction
|
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Apoptosis
|
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Hematopoietic cell lineage
|
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Amoebiasis
|
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HTLV-I infection
|
|
NetPath Pathway
|
IL5 Signaling Pathway
|
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FSH Signaling Pathway
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TCR Signaling PathwayNetPath_13:IL1 Signaling Pathway
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TSH Signaling Pathway
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IL4 Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
|
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IL5 Signaling PathwayNetPath_11:TCR Signaling Pathway
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IL2 Signaling Pathway
|
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PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
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Angiogenesis
|
|
B cell activation
|
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EGF receptor signaling pathway
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FGF signaling pathway
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Interferon-gamma signaling pathway
|
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Oxidative stress response
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Parkinson disease
|
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TGF-beta signaling pathway
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Toll receptor signaling pathway
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VEGF signaling pathway
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Ras Pathway
|
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p53 pathway feedback loops 2
|
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p38 MAPK pathway
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CCKR signaling map STP00019:Endothelin signaling pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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CCKR signaling map STP05918:p38 MAPK pathway
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|
Pathway Interaction Database
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Endothelins
|
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BCR signaling pathway
|
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p73 transcription factor network
|
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p38 MAPK signaling pathway
|
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Atypical NF-kappaB pathway
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IL4-mediated signaling events
|
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CD40/CD40L signaling
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IL12-mediated signaling events
|
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Regulation of p38-alpha and p38-beta
|
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CDC42 signaling events
|
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Angiopoietin receptor Tie2-mediated signaling
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FAS (CD95) signaling pathway
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Thromboxane A2 receptor signaling
|
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Role of Calcineurin-dependent NFAT signaling in lymphocytes
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Glucocorticoid receptor regulatory network
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IL2-mediated signaling events
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Rapid glucocorticoid signaling
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Regulation of Androgen receptor activity
|
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ATF-2 transcription factor network
|
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IL6-mediated signaling events
|
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p38 signaling mediated by MAPKAP kinases
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Retinoic acid receptors-mediated signaling
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CXCR3-mediated signaling events
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Signaling mediated by p38-alpha and p38-beta
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EPO signaling pathway
|
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Signaling events mediated by VEGFR1 and VEGFR2
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p53 pathway
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S1P2 pathway
|
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Trk receptor signaling mediated by the MAPK pathway
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VEGFR3 signaling in lymphatic endothelium
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FGF signaling pathway
|
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RAC1 signaling pathway
|
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Regulation of retinoblastoma proteinnfat_tfpathway:Calcineurin-regulated NFAT-dependent transcription in lymphocytes
|
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S1P1 pathway
|
|
C-MYB transcription factor network
|
|
Calcium signaling in the CD4+ TCR pathwayil12_2pathway:IL12-mediated signaling events
|
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IL1-mediated signaling events
|
|
PathWhiz Pathway
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Fc Epsilon Receptor I Signaling in Mast CellsPW000044:Arachidonic Acid Metabolism
|
|
Reactome
|
NOD1/2 Signaling Pathway
|
|
p38MAPK events
|
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ERK/MAPK targets
|
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Activation of PPARGC1A (PGC-1alpha) by phosphorylation
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Oxidative Stress Induced Senescence
|
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CDO in myogenesis
|
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DSCAM interactions
|
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ADP signalling through P2Y purinoceptor 1
|
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Platelet sensitization by LDL
|
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VEGFA-VEGFR2 Pathway
|
|
activated TAK1 mediates p38 MAPK activation
|
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Activation of the AP-1 family of transcription factors
|
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KSRP (KHSRP) binds and destabilizes mRNAR-HSA-446652:Interleukin-1 signaling
|
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WikiPathways
|
Toll-like receptor signaling pathway
|
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Monoamine Transport
|
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Serotonin HTR1 Group and FOS Pathway
|
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TCR Signaling Pathway
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Senescence and Autophagy in Cancer
|
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Interferon type I signaling pathways
|
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Insulin Signaling
|
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EGF/EGFR Signaling Pathway
|
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MAPK Cascade
|
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Oxidative Stress
|
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p38 MAPK Signaling Pathway
|
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IL-4 Signaling Pathway
|
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MAPK Signaling Pathway
|
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TGF beta Signaling Pathway
|
|
Kit receptor signaling pathway
|
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Cardiac Hypertrophic Response
|
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MAP kinase activation in TLR cascade
|
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Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
|
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Nanoparticle-mediated activation of receptor signaling
|
|
Structural Pathway of Interleukin 1 (IL-1)
|
|
JAK/STAT
|
|
Amyotrophic lateral sclerosis (ALS)
|
|
Alpha 6 Beta 4 signaling pathway
|
|
Cardiac Progenitor Differentiation
|
|
BDNF signaling pathway
|
|
Integrated Pancreatic Cancer Pathway
|
|
Oncostatin M Signaling Pathway
|
|
Parkinsons Disease Pathway
|
|
Corticotropin-releasing hormone
|
|
AGE/RAGE pathway
|
|
B Cell Receptor Signaling Pathway
|
|
Prostate Cancer
|
|
TSLP Signaling Pathway
|
|
TWEAK Signaling Pathway
|
|
FSH signaling pathway
|
|
Leptin signaling pathway
|
|
RANKL/RANK Signaling Pathway
|
|
miR-targeted genes in muscle cell - TarBase
|
|
miR-targeted genes in lymphocytes - TarBase
|
|
miR-targeted genes in leukocytes - TarBase
|
|
miR-targeted genes in epithelium - TarBase
|
|
IL-1 signaling pathway
|
|
Signal amplification
|
|
Platelet homeostasis
|
|
NGF signalling via TRKA from the plasma membrane
|
|
Myogenesis
|
|
DSCAM interactions
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Angiogenesis
|
|
Physiological and Pathological Hypertrophy of the Heart
|
|
Regulation of toll-like receptor signaling pathwayWP98:Prostaglandin Synthesis and Regulation
|
|
Arachidonic acid metabolism
|
|
Aryl Hydrocarbon Receptor
|
|
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
|
|
Spinal Cord Injury
|
|
Eicosanoid Synthesis
|
|
Selenium Micronutrient NetworkWP727:Monoamine Transport
|
|
Hypertrophy Model
|
|
IL1 and megakaryotyces in obesity
|
|
Interleukin-1 signaling
|
|
Apoptosis Modulation and Signaling
|
|
Serotonin Transporter Activity
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5269). |
|---|
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007147) |
|---|
| REF 3 | The p38 mitogen-activated protein kinase pathway plays a critical role in thrombin-induced endothelial chemokine production and leukocyte recruitment. Blood. 2001 Aug 1;98(3):667-73. |
|---|
| REF 4 | Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19. |
|---|
| REF 5 | Inhibition of p38 MAP kinase as a therapeutic strategy. Immunopharmacology. 2000 May;47(2-3):185-201. |
|---|
| REF 6 | IL-1- and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase. J Cell Physiol. 2001 Jun;187(3):294-303. |
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