Drug Information

Drug General Information
Drug ID
D0EQ0T
Former ID
DNC006016
Drug Name
CP-55940
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542321]
Structure
Download
2D MOL
Formula
C24H40O3
InChI
InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3/t18-,20-,22-/m1/s1
InChIKey
YNZFFALZMRAPHQ-SYYKKAFVSA-N
PubChem Compound ID
104895
PubChem Substance ID
10233661, 11110912, 14926865, 16501872, 17404752, 24278295, 44434471, 47424229, 48169362, 48393922, 50005506, 50104663, 50104664, 50628872, 53777295, 56463013, 57309818, 57337899, 71753421, 90340634, 92303455, 103112294, 103685290, 103966377, 104373169, 113635234, 117557366, 124749526, 124801426, 124886958, 126684044, 129823211, 134343221, 135061075, 135650130, 135651145, 137125085, 142472549, 162247816, 163564143, 164757773, 170481107, 223682617, 226492016, 241182008, 241377543, 250108652, 252457543, 252823772
Target and Pathway
Target(s) Cannabinoid receptor 2 Target Info Inhibitor [528562]
Cannabinoid receptor 1 Target Info Inhibitor [530009]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
BDNF signaling pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 542321(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 730).
Ref 528562J Med Chem. 2006 Dec 14;49(25):7502-12.Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide.
Ref 530009Bioorg Med Chem. 2009 Apr 1;17(7):2842-51. Epub 2009 Feb 21.Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists.

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