Target Information
Target General Infomation | |||||
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Target ID |
T87075
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Former ID |
TTDS00473
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Target Name |
T-cell surface glycoprotein CD3 epsilon chain
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Gene Name |
CD3E
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Synonyms |
CD3e; T-cell surface antigen T3/Leu-4 epsilon chain; T3E; CD3E
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Target Type |
Successful
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Disease | Advanced breast cancer [ICD9: 174, 175; ICD10: C50] | ||||
Breast cancer [ICD9: 174, 175; ICD10: C50] | |||||
Melanoma [ICD9: 172; ICD10: C43] | |||||
Organ rejection [ICD9: 279.5, 996; ICD10: D89.8, T86] | |||||
Prostate cancer [ICD9: 185; ICD10: C61] | |||||
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48] | |||||
Function |
The CD3 complex mediates signal transduction.
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Target Validation |
T87075
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UniProt ID | |||||
Sequence |
MQSGTHWRVLGLCLLSVGVWGQDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQ
HNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCE NCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERP PPVPNPDYEPIRKGQRDLYSGLNQRRI |
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Drugs and Mode of Action | |||||
Drug(s) | Muromonab | Drug Info | Approved | Organ rejection | [536361] |
Ertumaxomab | Drug Info | Phase 2 | Breast cancer | [529707], [531972] | |
Resimmune | Drug Info | Phase 1/2 | Melanoma | [549482] | |
Autologous T-cell therapy | Drug Info | Phase 1 | Prostate cancer | [525412] | |
Ertumaxomab | Drug Info | Phase 1 | Advanced breast cancer | [889343] | |
MT-110 | Drug Info | Phase 1 | Solid tumours | [531707] | |
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
Pathways | |||||
KEGG Pathway | Hematopoietic cell lineage | ||||
T cell receptor signaling pathway | |||||
Chagas disease (American trypanosomiasis) | |||||
Measles | |||||
HTLV-I infection | |||||
Primary immunodeficiency | |||||
NetPath Pathway | TCR Signaling Pathway | ||||
Leptin Signaling Pathway | |||||
PANTHER Pathway | T cell activation | ||||
Pathway Interaction Database | TCR signaling in na& | ||||
#xef | |||||
ve CD4+ T cells | |||||
IL12-mediated signaling events | |||||
TCR signaling in na& | |||||
ve CD8+ T cells | |||||
CXCR4-mediated signaling events | |||||
IL23-mediated signaling events | |||||
Downstream signaling in na& | |||||
IL12 signaling mediated by STAT4 | |||||
Reactome | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ||||
Phosphorylation of CD3 and TCR zeta chains | |||||
Translocation of ZAP-70 to Immunological synapse | |||||
Generation of second messenger molecules | |||||
PD-1 signaling | |||||
WikiPathways | TCR Signaling Pathway | ||||
TCR signaling | |||||
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | |||||
Costimulation by the CD28 family | |||||
References | |||||
Ref 525412 | Clinical application of genetically modified T cells in cancer therapy. Clin Transl Immunology. 2014 May 16;3(5):e16. doi: 10.1038/cti.2014.7. eCollection 2014. | ||||
Ref 529707 | Ertumaxomab: a trifunctional antibody for breast cancer treatment. Expert Opin Investig Drugs. 2008 Oct;17(10):1553-8. | ||||
Ref 531707 | EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin Cancer Res. 2012 Jan 15;18(2):465-74. | ||||
Ref 531972 | Trifunctional antibody ertumaxomab: Non-immunological effects on Her2 receptor activity and downstream signaling. MAbs. 2012 Sep-Oct;4(5):614-22. | ||||
Ref 536361 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
Ref 529707 | Ertumaxomab: a trifunctional antibody for breast cancer treatment. Expert Opin Investig Drugs. 2008 Oct;17(10):1553-8. | ||||
Ref 531707 | EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin Cancer Res. 2012 Jan 15;18(2):465-74. | ||||
Ref 531972 | Trifunctional antibody ertumaxomab: Non-immunological effects on Her2 receptor activity and downstream signaling. MAbs. 2012 Sep-Oct;4(5):614-22. |
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