Drug Information

Drug General Information
Drug ID
D00YOV
Former ID
DIB003741
Drug Name
MT-110
Synonyms
MuS110; Bispecific EpCAM/CD3 antibody (cancer), Micromet
Drug Type
Antibody
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [531707]
Company
Micromet AG
Target and Pathway
Target(s) CD3 Target Info [531707]
T-cell surface glycoprotein CD3 epsilon chain Target Info [531707]
Tumor-associated calcium signal transducer 1 Target Info [531707]
KEGG Pathway Hematopoietic cell lineage
T cell receptor signaling pathway
Chagas disease (American trypanosomiasis)
Measles
HTLV-I infectionhsa04640:Hematopoietic cell lineage
HTLV-I infection
Primary immunodeficiency
NetPath Pathway TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway T cell activationP00053:T cell activation
Pathway Interaction Database TCR signaling in na&#xef
IL12-mediated signaling events
TCR signaling in na&#xef
CXCR4-mediated signaling events
Downstream signaling in na&#xef
IL12 signaling mediated by STAT4tcr_pathway:TCR signaling in na&#xef
IL23-mediated signaling events
IL12 signaling mediated by STAT4
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
PD-1 signalingR-HSA-198933:Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
PD-1 signaling
WikiPathways TCR Signaling Pathway
Fcgamma receptor (FCGR) dependent phagocytosis
TCR signaling
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Costimulation by the CD28 familyWP69:TCR Signaling Pathway
Costimulation by the CD28 family
References
Ref 531707EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin Cancer Res. 2012 Jan 15;18(2):465-74.
Ref 531707EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin Cancer Res. 2012 Jan 15;18(2):465-74.

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