Drug Information

Drug General Information
Drug ID
D0T5WY
Former ID
DNC006984
Drug Name
JWH-293
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528355]
Structure
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2D MOL

3D MOL
Formula
C26H24N2O3
Canonical SMILES
CCCCCN1C=C(C=C1C2=CC(=CC=C2)[N+](=O)[O-])C(=O)C3=CC=CC4<br />=CC=CC=C43
InChI
1S/C26H24N2O3/c1-2-3-6-15-27-18-21(17-25(27)20-11-7-12-22(16-20)28(30)31)26(29)24-14-8-10-19-9-4-5-13-23(19)24/h4-5,7-14,16-18H,2-3,6,15H2,1H3
InChIKey
FQGNQKRWZNTBLM-UHFFFAOYSA-N
PubChem Compound ID
44418344
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Inhibitor [528355]
Cannabinoid receptor 2 Target Info Inhibitor [528355]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signalinghsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 528355Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. Epub 2006 Aug 4.1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors.
Ref 528355Bioorg Med Chem Lett. 2006 Oct 15;16(20):5432-5. Epub 2006 Aug 4.1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors.

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