Drug Information

Drug General Information
Drug ID
D06ZCX
Former ID
DNC004245
Drug Name
LY-326449
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534154]
Structure
Download
2D MOL

3D MOL
Formula
C26H23N3O4
Canonical SMILES
C1CN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCOC1CO)C6=CC=CC=C65)C<br />(=O)NC4=O
InChI
1S/C26H23N3O4/c30-15-16-9-10-28-13-19(17-5-1-3-7-21(17)28)23-24(26(32)27-25(23)31)20-14-29(11-12-33-16)22-8-4-2-6-18(20)22/h1-8,13-14,16,30H,9-12,15H2,(H,27,31,32)/t16-/m0/s1
InChIKey
BGVKOUSMQGMSDY-INIZCTEOSA-N
PubChem Compound ID
10455969
Target and Pathway
Target(s) Protein kinase C, theta type Target Info Inhibitor [534154]
mRNA of PKC-zeta Target Info Inhibitor [534154]
Protein kinase C, epsilon type Target Info Inhibitor [534154]
mRNA of PKC-delta Target Info Inhibitor [534154]
Protein kinase C, delta type Target Info Inhibitor [534154]
Protein kinase C gamma type Target Info Inhibitor [534154]
mRNA of human PKC-eta Target Info Inhibitor [534154]
Protein kinase C, alpha type Target Info Inhibitor [534154]
Protein kinase C, beta type Target Info Inhibitor [534154]
Protein kinase C, zeta type Target Info Inhibitor [534154]
KEGG Pathway NF-kappa B signaling pathway
Vascular smooth muscle contraction
Tight junction
T cell receptor signaling pathway
Inflammatory mediator regulation of TRP channels
Adipocytokine signaling pathway
Measleshsa04015:Rap1 signaling pathway
Chemokine signaling pathway
Sphingolipid signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Hippo signaling pathway
Platelet activation
Insulin signaling pathway
Type II diabetes mellitushsa04022:cGMP-PKG signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Type II diabetes mellitus
MicroRNAs in cancerhsa04062:Chemokine signaling pathway
Neurotrophin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Type II diabetes mellitushsa04062:Chemokine signaling pathway
Type II diabetes mellitushsa04010:MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
Wnt signaling pathway
VEGF signaling pathway
Focal adhesion
Gap junction
Natural killer cell mediated cytotoxicity
Leukocyte transendothelial migration
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Long-term depression
Insulin secretion
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
African trypanosomiasis
Amoebiasis
Hepatitis B
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Choline metabolism in cancerhsa04270:Vascular smooth muscle contraction
Inflammatory mediator regulation of TRP channelshsa04010:MAPK signaling pathway
Adrenergic signaling in cardiomyocytes
Pathogenic Escherichia coli infection
Influenza A
Choline metabolism in cancerhsa04010:MAPK signaling pathway
B cell receptor signaling pathway
Carbohydrate digestion and absorption
Leishmaniasis
Choline metabolism in cancerhsa04015:Rap1 signaling pathway
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
T cell activation
VEGF signaling pathway
Wnt signaling pathway
5HT2 type receptor mediated signaling pathway
Histamine H1 receptor mediated signaling pathway
Oxytocin receptor mediated signaling pathway
Thyrotropin-releasing hormone receptor signaling pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Thyrotropin-releasing hormone receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
CCKR signaling map STP00002:Alpha adrenergic receptor signaling pathway
B cell activation
Thyrotropin-releasing hormone receptor signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
PDGF signaling pathway
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Metabotropic glutamate receptor group I pathway
Pathway Interaction Database Endothelins
TCR signaling in na&#xef
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
TCR signaling in na&#xef
Thromboxane A2 receptor signaling
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Downstream signaling in na&#xef
RhoA signaling pathway
Insulin Pathway
Noncanonical Wnt signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
CDC42 signaling events
IL1-mediated signaling events
CXCR4-mediated signaling events
IGF1 pathway
TNF receptor signaling pathway
IL2 signaling events mediated by PI3K
Ceramide signaling pathway
p75(NTR)-mediated signaling
amb2 Integrin signaling
ErbB1 downstream signaling
Neurotrophic factor-mediated Trk receptor signaling
Nephrin/Neph1 signaling in the kidney podocyte
Insulin-mediated glucose transport
Regulation of Ras family activationendothelinpathway:Endothelins
LPA receptor mediated events
LPA4-mediated signaling events
IL2-mediated signaling events
PDGFR-beta signaling pathway
IL8- and CXCR1-mediated signaling events
Regulation of Ras family activation
Endothelins
IFN-gamma pathway
Syndecan-4-mediated signaling events
IL6-mediated signaling events
Hedgehog signaling events mediated by Gli proteins
Signaling events mediated by VEGFR1 and VEGFR2
PAR1-mediated thrombin signaling events
Syndecan-2-mediated signaling events
Validated transcriptional targets of TAp63 isoforms
p53 pathway
Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Alpha-synuclein signalingendothelinpathway:Endothelins
Retinoic acid receptors-mediated signaling
IL8- and CXCR2-mediated signaling events
IL8- and CXCR1-mediated signaling eventsendothelinpathway:Endothelins
Role of Calcineurin-dependent NFAT signaling in lymphocytesendothelinpathway:Endothelins
Canonical NF-kappaB pathway
Signaling events regulated by Ret tyrosine kinase
mTOR signaling pathway
Ras signaling in the CD4+ TCR pathway
ATF-2 transcription factor network
VEGFR1 specific signals
a6b1 and a6b4 Integrin signaling
Fc-epsilon receptor I signaling in mast cells
JNK signaling in the CD4+ TCR pathway
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000453:Fc Epsilon Receptor I Signaling in Mast Cells
Activation of PKC through G protein coupled receptorPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Apoptotic cleavage of cellular proteins
Effects of PIP2 hydrolysis
Inactivation, recovery and regulation of the phototransduction cascade
FCERI mediated NF-kB activation
G alpha (z) signalling eventsR-HSA-114604:GPVI-mediated activation cascade
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
VEGFR2 mediated cell proliferationR-HSA-114508:Effects of PIP2 hydrolysis
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling eventsR-HSA-111465:Apoptotic cleavage of cellular proteins
Calmodulin induced events
G alpha (z) signalling events
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
Interferon gamma signalingR-HSA-111465:Apoptotic cleavage of cellular proteins
Interferon gamma signalingR-HSA-111933:Calmodulin induced events
Disinhibition of SNARE formation
Trafficking of GluR2-containing AMPA receptors
WNT5A-dependent internalization of FZD4
Response to elevated platelet cytosolic Ca2+R-HSA-114508:Effects of PIP2 hydrolysis
G alpha (z) signalling eventsR-HSA-111933:Calmodulin induced events
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Syndecan interactions
Acetylcholine regulates insulin secretion
Ca2+ pathway
Depolymerisation of the Nuclear Lamina
Response to elevated platelet cytosolic Ca2+R-HSA-114516:Disinhibition of SNARE formation
Activation of NF-kappaB in B cells
Response to elevated platelet cytosolic Ca2+R-HSA-114604:GPVI-mediated activation cascade
WikiPathways TCR Signaling Pathway
Calcium Regulation in the Cardiac Cell
Insulin Signaling
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Fc epsilon receptor (FCERI) signaling
Corticotropin-releasing hormone
Signaling Pathways in Glioblastoma
miRs in Muscle Cell Differentiation
TCR signaling
Netrin-1 signaling
GPCR downstream signaling
Effects of PIP2 hydrolysis
Apoptotic execution phaseWP536:Calcium Regulation in the Cardiac Cell
EGF/EGFR Signaling Pathway
MAPK Signaling Pathway
Signaling by TGF-beta Receptor Complex
Allograft Rejection
AGE/RAGE pathway
TNF alpha Signaling Pathway
IL-1 signaling pathway
GPVI-mediated activation cascade
Type II diabetes mellitusWP666:Hypothetical Network for Drug Addiction
Oncostatin M Signaling Pathway
Physiological and Pathological Hypertrophy of the HeartWP69:TCR Signaling Pathway
Type II interferon signaling (IFNG)
IL-6 signaling pathway
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
DAG and IP3 signaling
Alpha 6 Beta 4 signaling pathway
BDNF signaling pathway
B Cell Receptor Signaling Pathway
Opioid Signalling
Apoptotic execution phase
Type II diabetes mellitusWP69:TCR Signaling Pathway
Type II diabetes mellitusWP536:Calcium Regulation in the Cardiac Cell
Wnt Signaling Pathway Netpath
Response to elevated platelet cytosolic Ca2+WP536:Calcium Regulation in the Cardiac Cell
Effects of PIP2 hydrolysisWP673:ErbB Signaling Pathway
Kit receptor signaling pathway
Transcriptional activation by NRF2
Human Complement System
Cardiac Hypertrophic Response
Syndecan interactions
Signaling by SCF-KIT
Gastrin-CREB signalling pathway via PKC and MAPK
T-Cell Receptor and Co-stimulatory Signaling
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Pathogenic Escherichia coli infection
Endothelin Pathways
Regulation of Microtubule Cytoskeleton
FSH signaling pathway
Response to elevated platelet cytosolic Ca2+
Integration of energy metabolism
TOR SignalingWP536:Calcium Regulation in the Cardiac Cell
Signaling by the B Cell Receptor (BCR)
MicroRNAs in cardiomyocyte hypertrophy
Physiological and Pathological Hypertrophy of the HeartWP536:Calcium Regulation in the Cardiac Cell
Type II diabetes mellitus
References
Ref 534154J Med Chem. 1996 Jul 5;39(14):2664-71.(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.
Ref 534154J Med Chem. 1996 Jul 5;39(14):2664-71.(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.

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