Drug Information

Drug General Information
Drug ID
D04HXF
Former ID
DNC010897
Drug Name
1-(2-isopropylphenoxy)-3-morpholinopropan-2-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530883]
Structure
Download
2D MOL

3D MOL
Formula
C16H25NO3
Canonical SMILES
CC(C)C1=CC=CC=C1OCC(CN2CCOCC2)O
InChI
1S/C16H25NO3/c1-13(2)15-5-3-4-6-16(15)20-12-14(18)11-17-7-9-19-10-8-17/h3-6,13-14,18H,7-12H2,1-2H3
InChIKey
OFEYQVJHAZFCJS-UHFFFAOYSA-N
PubChem Compound ID
4080436
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Inhibitor [530883]
Beta-3 adrenergic receptor Target Info Inhibitor [530883]
Beta-2 adrenergic receptor Target Info Inhibitor [530883]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathyhsa04020:Calcium signaling pathway
Salivary secretionhsa04020:Calcium signaling pathway
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Vitamin D Receptor Pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 530883Bioorg Med Chem Lett. 2010 Jun 1;20(11):3399-404. Epub 2010 Apr 9.A vHTS approach for the identification of beta-adrenoceptor ligands.
Ref 530883Bioorg Med Chem Lett. 2010 Jun 1;20(11):3399-404. Epub 2010 Apr 9.A vHTS approach for the identification of beta-adrenoceptor ligands.

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