Target General Information
Target ID T05152
Target Name HCV RNA-directed RNA polymerase (NS5B)
Gene Name NS5B
Species Hepatitis C virus genotype 1b
UniProt ID POLG_HCVJA(2420-3010)
Sequence SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHSMVYSTTSRSASLRQKKVTFDRLQVL
DDHYRDVLKEMKAKASTVKARLLSIEEACKLTPPHSAKSKFGYGAKDVRSLSSRAVNHIR
SVWEDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVS
TLPQAVMGPSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTENDIRTEESIY
QCCDLAPEARQAIRSLTERLYVGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKAT
AACRAAKLQDCTMLVNGDDLVVICESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDL
ELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETVRHTPVNSWLGNIIMYAPTLW
ARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPG
EINRVASCLRKLGVPPLRVWRHRARSVRAKLLSQGGRAATCGKYLFNWAVKTKLKLTPIP
AASQLDLSGWFVAGYNGGDIYHSLSRARPRWFMLCLLLLSVGVGIYLLPNR [Hepatit
is C virus genotype 1b]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: F415Y
Drugs
Drug Name Ribavirin Drug Info [1]
Targeted Disease HCV infection
Mutation Info Missense: S282T
Drugs
Drug Name Sofosbuvir Drug Info [2]
Targeted Disease HCV infection
References
REF 1 Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-nae patients. Hepatology. 2008 Dec;48(6):1769-78.
REF 2 Lam, A.M. et al. Selection and characterization of heaptitis C virus replicons using combinations of NS3 protease and NS5B non-nucleoside inhibitors or combination of NS5B nucleotide inhibitors. . in International HIV & Hepatitis Virus Drug Resistance Workshop, Vol. 15 Supplement 2 A28 (Dubrovnik, Croatia, 2010).

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